Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

(2021) Chao Wang et al.   Pharmaceuticals

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

(2021) Shurong Hou et al.   Pharmaceuticals

The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B

(2021) Ulrich Eckhard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity

(2021) Julien Robert-Paganin et al.   Nature Communications

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

(2021) Miriam Linnert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

(2021) Ali Punjani et al.   JOURNAL OF STRUCTURAL BIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

New tools for automated cryo-EM single-particle analysis in RELION-4.0

(2021) Dari Kimanius et al.   BIOCHEMICAL JOURNAL

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Two particle-picking procedures for filamentous proteins: SPHIRE-crYOLO filament mode and SPHIRE-STRIPER

(2020) Thorsten Wagner et al.   Acta Crystallographica Section D-Structural Biology

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes

(2019) Florian Peters et al.   FASEB JOURNAL

Tripeptidyl-peptidase II: Update on an oldie that still counts

(2019) Birgitta Tomkinson   BIOCHIMIE

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of meprin metalloproteases in metastasis and tumor microenvironment

(2019) Florian Peters et al.   CANCER AND METASTASIS REVIEWS

Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM

(2019) Satoshi Shibata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

Structure of the native supercoiled flagellar hook as a universal joint

(2019) Takayuki Kato et al.   Nature Communications

Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α

(2018) Kathrin Tan et al.   ChemMedChem

Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors

(2018) Daniel Ramsbeck et al.   JOURNAL OF MEDICINAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s

(2018) Matthieu P.M.H. Benoit et al.   Nature Communications

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Role of meprin metalloproteinases in cytokine processing and inflammation

(2018) Christian Herzog et al.   CYTOKINE

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

(2017) Tillmann Bedau et al.   FASEB JOURNAL

Automated tilt series alignment and tomographic reconstruction in IMOD

(2017) David N. Mastronarde et al.   JOURNAL OF STRUCTURAL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

(2017) Rielana Wichert et al.   Cell Reports

Meprin β contributes to collagen deposition in lung fibrosis

(2017) V. Biasin et al.   Scientific Reports

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

(2017) Philipp Arnold et al.   Scientific Reports

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Meprin α and meprin β: Procollagen proteinases in health and disease

(2015) Johannes Prox et al.   MATRIX BIOLOGY

Protein carbamylation is a hallmark of aging

(2015) Laëtitia Gorisse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

(2015) Serban L. Ilca et al.   Nature Communications

Origin and Diversification of Meprin Proteases

(2015) Ignacio Marín   PLoS One

Switching from Protease-Independent to Protease-Dependent Cancer Cell Invasion

(2014) Lijuan He et al.   BIOPHYSICAL JOURNAL

Meprin Metalloproteases Inactivate Interleukin 6

(2014) Timothy R. Keiffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A

(2014) Christian Herzog et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Meprinβ, a novel mediator of vascular remodelling underlying pulmonary hypertension

(2013) Valentina Biasin et al.   JOURNAL OF PATHOLOGY

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration

(2012) Petra Minder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamo: A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments

(2012) Daniel Castaño-Díez et al.   JOURNAL OF STRUCTURAL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structural basis for the sheddase function of human meprin   metalloproteinase at the plasma membrane

(2012) J. L. Arolas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

(2011) Christoph Becker-Pauly et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli

(2011) Emilie Vazeille et al.   PLoS One

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer

(2011) Daniel Lottaz et al.   PLoS One

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

(2010) Daniel Kronenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α2

(2010) André Schütte et al.   PLoS One

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Meprin A and meprin α generate biologically functional IL-1β from pro-IL-1β

(2009) Christian Herzog et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meprins, membrane-bound and secreted astacin metalloproteinases

(2008) E STERCHI et al.   MOLECULAR ASPECTS OF MEDICINE