The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

(2012) Mehmet Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional and structural insights into astacin metallopeptidases

(2012) F. Xavier Gomis-Rüth et al.   BIOLOGICAL CHEMISTRY

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration

(2012) Petra Minder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of fibrillar collagen trimerization and related genetic disorders

(2012) Jean-Marie Bourhis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the sheddase function of human meprin   metalloproteinase at the plasma membrane

(2012) J. L. Arolas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of cerebrospinal fluid aminoterminally truncated and oxidized amyloid-β peptides

(2012) Mirko Bibl et al.   Proteomics Clinical Applications

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

A Role for Metalloendopeptidases in the Breakdown of the Gut Hormone, PYY3–36

(2011) Melisande L. Addison et al.   ENDOCRINOLOGY

Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney

(2011) M. Hirano et al.   GLYCOBIOLOGY

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of α-secretase cleavage

(2011) Rolf Postina   JOURNAL OF NEUROCHEMISTRY

Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

(2011) Christoph Becker-Pauly et al.   MOLECULAR & CELLULAR PROTEOMICS

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

(2011) Oded Kleifeld et al.   Nature Protocols

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

(2011) Oliver Schilling et al.   Nature Protocols

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli

(2011) Emilie Vazeille et al.   PLoS One

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer

(2011) Daniel Lottaz et al.   PLoS One

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease

(2010) Sanjita Banerjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases

(2010) Jana Hedrich et al.   BIOCHEMISTRY

Proteomic techniques and activity-based probes for the system-wide study of proteolysis

(2010) Ulrich auf dem Keller et al.   BIOCHIMIE

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

(2010) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

(2010) Sonya Cosgrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

(2010) Daniel Kronenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

A Statistics-based Platform for Quantitative N-terminome Analysis and Identification of Protease Cleavage Products

(2010) Ulrich auf dem Keller et al.   MOLECULAR & CELLULAR PROTEOMICS

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α2

(2010) André Schütte et al.   PLoS One

Actinonin, a Meprin a Inhibitor, Protects the Renal Microcirculation During Sepsis

(2010) Zhen Wang et al.   SHOCK

B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity

(2009) Guido Boerrigter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Meprin A and meprin α generate biologically functional IL-1β from pro-IL-1β

(2009) Christian Herzog et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrix metalloproteinases: Evolution, gene regulation and functional analysis in mouse models

(2009) Miriam Fanjul-Fernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Specific processing of tenascin-C by the metalloprotease meprinβ neutralizes its inhibition of cell spreading

(2009) Daniel Ambort et al.   MATRIX BIOLOGY

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease

(2009) S Banerjee et al.   Mucosal Immunology

Identification of Novel APP/Aβ Isoforms in Human Cerebrospinal Fluid

(2009) Erik Portelius et al.   Neurodegenerative Diseases

Disruption of the meprin α and β genes in mice alters homeostasis of monocytes and natural killer cells

(2008) Qi Sun et al.   EXPERIMENTAL HEMATOLOGY

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway

(2008) David A. Bergin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

News from an Ancient World: Two Novel Astacin Metalloproteases from the Horseshoe Crab

(2008) Christoph Becker-Pauly et al.   JOURNAL OF MOLECULAR BIOLOGY

Meprins, membrane-bound and secreted astacin metalloproteinases

(2008) E STERCHI et al.   MOLECULAR ASPECTS OF MEDICINE

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion

(2008) Maya Huguenin et al.   PLoS One

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis

(2008) Beatrice Oneda et al.   PLoS One

Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats

(2007) Junji Takayama et al.   EUROPEAN JOURNAL OF PHARMACOLOGY