ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells

(2011) Rong Cong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity

(2011) David R. Gibb et al.   MOLECULAR IMMUNOLOGY

Activation of the epithelial sodium channel by the metalloprotease meprin β subunit

(2010) Agustin Garcia-Caballero et al.   Channels

Fluorescent Substrates Useful as High Throughput Screening Tools for ADAM9

(2010) Marcia L. Moss et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)

(2010) Jinsook Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

(2010) Daniel Kronenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α2

(2010) André Schütte et al.   PLoS One

Actinonin, a Meprin a Inhibitor, Protects the Renal Microcirculation During Sepsis

(2010) Zhen Wang et al.   SHOCK

Meprin A and meprin α generate biologically functional IL-1β from pro-IL-1β

(2009) Christian Herzog et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ADAM10 as a Therapeutic Target for Cancer and Inflammation

(2009) Howard Crawford et al.   CURRENT PHARMACEUTICAL DESIGN

Specific processing of tenascin-C by the metalloprotease meprinβ neutralizes its inhibition of cell spreading

(2009) Daniel Ambort et al.   MATRIX BIOLOGY

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

(2008) Miriam Deuss et al.   Current Alzheimer Research

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway

(2008) David A. Bergin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

(2008) Anja Schramme et al.   KIDNEY INTERNATIONAL

Special issue: Metzincin metalloproteinases

(2008) E STERCHI   MOLECULAR ASPECTS OF MEDICINE

Meprins, membrane-bound and secreted astacin metalloproteinases

(2008) E STERCHI et al.   MOLECULAR ASPECTS OF MEDICINE

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion

(2008) Maya Huguenin et al.   PLoS One

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis

(2008) Beatrice Oneda et al.   PLoS One

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

(2008) Jessica Pruessmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats

(2007) Junji Takayama et al.   EUROPEAN JOURNAL OF PHARMACOLOGY