Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

The Blood Component Iron Causes Neuronal Apoptosis Following Intracerebral Hemorrhage via the PERK Pathway

(2020) Muyao Wu et al.   Frontiers in Neurology

The Scripps Molecular Screening Center and Translational Research Institute

(2019) Pierre Baillargeon et al.   SLAS Discovery

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of meprin metalloproteases in metastasis and tumor microenvironment

(2019) Florian Peters et al.   CANCER AND METASTASIS REVIEWS

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

(2019) Gregg B. Fields   Cells

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation

(2019) Julie Farand et al.   ACS Medicinal Chemistry Letters

Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α

(2018) Kathrin Tan et al.   ChemMedChem

Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors

(2018) Daniel Ramsbeck et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

(2017) Christoph Becker-Pauly et al.   Frontiers in Molecular Neuroscience

Meprin β contributes to collagen deposition in lung fibrosis

(2017) V. Biasin et al.   Scientific Reports

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

(2016) Franck Madoux et al.   Scientific Reports

Meprin α and meprin β: Procollagen proteinases in health and disease

(2015) Johannes Prox et al.   MATRIX BIOLOGY

Application of RNAi to Genomic Drug Target Validation in Schistosomes

(2015) Alessandra Guidi et al.   PLoS Neglected Tropical Diseases

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β

(2014) Franck Madoux et al.   BIOPOLYMERS

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

(2010) Anke Ohler et al.   BIOLOGICAL CHEMISTRY