Mechanical Force Directs Proliferation and Differentiation of Stem Cells

Interplay between mechanics and signalling in regulating cell fate

(2022) Henry De Belly et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanics and functional consequences of nuclear deformations

(2022) Yohalie Kalukula et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TiO2 Nanotubes Promote Osteogenic Differentiation Through Regulation of Yap and Piezo1

(2022) Keyu Kong et al.   Frontiers in Bioengineering and Biotechnology

Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes

(2022) Manato Kenmochi et al.   Journal of Physiological Sciences

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

(2021) Ben Sorum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels

(2021) Yan Jiang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

(2021) Jason S. Silver et al.   Science Advances

The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability

(2021) Amira Fitieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular models of LINC complex assembly at the nuclear envelope

(2021) Zeinab Jahed et al.   JOURNAL OF CELL SCIENCE

Force-Dependent Interactions between Talin and Full-Length Vinculin

(2021) Yinan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

(2021) Akihiro Kaneshige et al.   Cell Stem Cell

The cellular environment shapes the nuclear pore complex architecture

(2021) Anthony P. Schuller et al.   NATURE

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling

(2020) Debadrita Bhattacharya et al.   DEVELOPMENTAL CELL

Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation

(2020) Jian Sun et al.   Science Advances

Caveolae: Formation, dynamics, and function

(2020) Robert G. Parton et al.   CURRENT OPINION IN CELL BIOLOGY

Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

(2020) Laurent Fattet et al.   DEVELOPMENTAL CELL

Piezo1 is required for outflow tract and aortic valve development.

(2020) Adèle Faucherre et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus

(2020) Svenja Ulferts et al.   Cold Spring Harbor Perspectives in Biology

Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

(2020) Henry De Belly et al.   Cell Stem Cell

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

(2019) Tiina Viita et al.   JOURNAL OF CELL SCIENCE

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Hippo signalling during development

(2019) John Robert Davis et al.   DEVELOPMENT

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

(2019) Anne-Laure Duchemin et al.   eLife

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

Caveolae

(2018) Robert G. Parton et al.   CURRENT BIOLOGY

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling

(2018) Joseph Chen et al.   STEM CELLS

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Designing stem cell niches for differentiation and self-renewal

(2018) Hannah Donnelly et al.   Journal of the Royal Society Interface

Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response

(2018) Karthik Damodaran et al.   MOLECULAR BIOLOGY OF THE CELL

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae

(2018) Valentina Rausch et al.   CURRENT BIOLOGY

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

(2018) Stéphanie Torrino et al.   JOURNAL OF CELL BIOLOGY

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

(2018) Swetha E Murthy et al.   eLife

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane tension: A challenging but universal physical parameter in cell biology

(2017) Bruno Pontes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

(2017) Jamison L. Nourse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6

(2017) Ana Paula Zen Petisco Fiore et al.   Cell Reports

Reprogramming cell fates by small molecules

(2017) Xiaojie Ma et al.   Protein & Cell

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation

(2016) Andrew W. Holle et al.   Integrative Biology

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Biologic-free mechanically induced muscle regeneration

(2016) Christine A. Cezar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

(2016) C De Ford et al.   Cell Death & Disease

Substrate Stress-Relaxation Regulates Scaffold Remodeling and Bone Formation In Vivo

(2016) Max Darnell et al.   Advanced Healthcare Materials

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

(2015) Giorgio G. Galli et al.   MOLECULAR CELL

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Signal integration by Ca2+ regulates intestinal stem-cell activity

(2015) Hansong Deng et al.   NATURE

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

(2015) Jila N. Ajeian et al.   Proteomics Clinical Applications

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

(2014) John E. Mahoney et al.   DEVELOPMENTAL CELL

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis

(2014) R. Strippoli et al.   EMBO Molecular Medicine

Using biomaterials to study stem cell mechanotransduction, growth and differentiation

(2014) Rebecca J. McMurray et al.   Journal of Tissue Engineering and Regenerative Medicine

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells

(2013) Jae-Won Shin et al.   Cell Stem Cell

Piezo1 plays a role in erythrocyte volume homeostasis

(2013) A. Faucherre et al.   HAEMATOLOGICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ mechanotransduction via vinculin regulates stem cell differentiation

(2013) Andrew W. Holle et al.   STEM CELLS

Membrane curvature and its generation by BAR proteins

(2012) Carsten Mim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biophysical Regulation of Histone Acetylation in Mesenchymal Stem Cells

(2011) Yuan Li et al.   BIOPHYSICAL JOURNAL

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

More than a feeling: discovering, understanding, and influencing mechanosensing pathways

(2011) Andrew W Holle et al.   CURRENT OPINION IN BIOTECHNOLOGY

G-actin Participates in RNA Polymerase II-dependent Transcription Elongation by Recruiting Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tianyang Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental validation of atomic force microscopy-based cell elasticity measurements

(2011) Andrew R Harris et al.   NANOTECHNOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Combining Alkaline Phosphatase Treatment and Hybrid Linear Ion Trap/Orbitrap High Mass Accuracy Liquid Chromatography−Mass Spectrometry Data for the Efficient and Confident Identification of Protein Phosphorylation

(2009) Hsin-Yi Wu et al.   ANALYTICAL CHEMISTRY

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Designing materials to direct stem-cell fate

(2009) Matthias P. Lutolf et al.   NATURE

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

(2008) Kathryn N. Ivey et al.   Cell Stem Cell

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

(2008) S. Busche et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY