Designing stem cell niches for differentiation and self-renewal

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

(2018) Lorna Ewart et al.   Annual Review of Pharmacology and Toxicology

Biomechanical regulation of drug sensitivity in an engineered model of human tumor

(2018) A. Marturano-Kruik et al.   BIOMATERIALS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

(2018) Thomas C. von Erlach et al.   NATURE MATERIALS

Receptor control in mesenchymal stem cell engineering

(2018) Matthew J. Dalby et al.   Nature Reviews Materials

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

(2017) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

(2017) Aline Roch et al.   Nature Communications

Limb proportions show developmental plasticity in response to embryo movement

(2017) A. S. Pollard et al.   Scientific Reports

Bone and cartilage differentiation of a single stem cell population driven by material interface

(2017) Hannah Donnelly et al.   Journal of Tissue Engineering

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

(2016) Jemma N. Roberts et al.   ACS Nano

Protein Adsorption as a Key Mediator in the Nanotopographical Control of Cell Behavior

(2016) Elie Ngandu Mpoyi et al.   ACS Nano

A Quiescent, Regeneration-Responsive Tissue Engineered Mesenchymal Stem Cell Bone Marrow Niche Model via Magnetic Levitation

(2016) Emily Elizabeth Louise Lewis et al.   ACS Nano

Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo

(2016) Roberta Fraioli et al.   Acta Biomaterialia

Synergistic growth factor microenvironments

(2016) Manuel Salmerón-Sánchez et al.   CHEMICAL COMMUNICATIONS

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Tissue-specific designs of stem cell hierarchies

(2016) Jane E. Visvader et al.   NATURE CELL BIOLOGY

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Mesenchymal stem cell-based therapy in kidney transplantation

(2016) Cheng Chen et al.   Stem Cell Research & Therapy

Analysis of Osteoclastogenesis/Osteoblastogenesis on Nanotopographical Titania Surfaces

(2016) Robert K. Silverwood et al.   Advanced Healthcare Materials

Material-driven fibronectin assembly for high-efficiency presentation of growth factors

(2016) V. Llopis-Hernandez et al.   Science Advances

Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model

(2016) Marta Cavo et al.   Scientific Reports

Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates

(2016) P. M. Tsimbouri et al.   Scientific Reports

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

(2015) Adam D. Celiz et al.   ADVANCED MATERIALS

Simple coating with fibronectin fragment enhances stainless steel screw osseointegration in healthy and osteoporotic rats

(2015) Rachit Agarwal et al.   BIOMATERIALS

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

(2015) Elisa Laurenti et al.   Cell Stem Cell

Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events

(2015) Elisabeth H. Schwab et al.   NANO LETTERS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Deregulation and therapeutic potential of microRNAs in arthritic diseases

(2015) Rita Vicente et al.   Nature Reviews Rheumatology

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Hydrogel: Preparation, characterization, and applications: A review

(2015) Enas M. Ahmed   Journal of Advanced Research

Nanotopographical Induction of Osteogenesis through Adhesion, Bone Morphogenic Protein Cosignaling, and Regulation of MicroRNAs

(2014) Jingli Yang et al.   ACS Nano

Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

(2014) Yanjiao Jiang et al.   BIOMATERIALS

Autologous Bone Marrow Transplantation for the Treatment of Multiple Sclerosis

(2014) Marta Radaelli et al.   Current Neurology and Neuroscience Reports

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Modulating the stem cell niche for tissue regeneration

(2014) Steven W Lane et al.   NATURE BIOTECHNOLOGY

Materials for stem cell factories of the future

(2014) Adam D. Celiz et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration

(2014) E.A. Blaber et al.   Stem Cell Research

Investigation of the limits of nanoscale filopodial interactions

(2014) Laura E McNamara et al.   Journal of Tissue Engineering

Limbal stem cells: Central concepts of corneal epithelial homeostasis

(2014) Jinny J Yoon   World Journal of Stem Cells

Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces: The role of focal adhesion maturation

(2013) John W. Cassidy et al.   Acta Biomaterialia

A genomics approach in determining nanotopographical effects on MSC phenotype

(2013) Penelope M. Tsimbouri et al.   BIOMATERIALS

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis

(2013) L. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Highly confined ions store charge more efficiently in supercapacitors

(2013) C. Merlet et al.   Nature Communications

2D and 3D Nanopatterning of Titanium for Enhancing Osteoinduction of Stem Cells at Implant Surfaces

(2013) Terje Sjöström et al.   Advanced Healthcare Materials

Using Nanotopography and Metabolomics to Identify Biochemical Effectors of Multipotency

(2012) P. Monica Tsimbouri et al.   ACS Nano

Fine-Tuning the Degree of Stem Cell Polarization and Alignment on Ordered Arrays of High-Aspect-Ratio Nanopillars

(2012) Michael A. Bucaro et al.   ACS Nano

The role of microtopography in cellular mechanotransduction

(2012) Laura E. McNamara et al.   BIOMATERIALS

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Adult Neural Stem Cells Bridge Their Niche

(2012) Luis C. Fuentealba et al.   Cell Stem Cell

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database

(2012) Emily Jane Woo   Spine Journal

Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis

(2012) Melissa A. Kinney et al.   TRENDS IN BIOTECHNOLOGY

Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients

(2011) Peng-Yuan Wang et al.   Acta Biomaterialia

Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

(2011) Cole A. DeForest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves

(2011) Shinya Watari et al.   BIOMATERIALS

Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

(2011) Vicki P. Losick et al.   DEVELOPMENTAL CELL

A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis

(2011) William P. Daley et al.   DEVELOPMENTAL DYNAMICS

The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in

(2011) Armin Ehninger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

(2011) Mark Schvartzman et al.   NANO LETTERS

Focal Complex Maturation and Bridging on 200 nm Vitronectin but Not Fibronectin Patches Reveal Different Mechanisms of Focal Adhesion Formation

(2011) Jenny Malmström et al.   NANO LETTERS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing

(2011) M. M. Martino et al.   Science Translational Medicine

Concise Review: A Chemical Approach to Control Cell Fate and Function

(2011) Wenlin Li et al.   STEM CELLS

Concise Review: Mesenchymal Stem Cell Tumor-Homing: Detection Methods in Disease Model Systems

(2011) Michaela R. Reagan et al.   STEM CELLS

Role of material-driven fibronectin fibrillogenesis in cell differentiation

(2010) Manuel Salmerón-Sánchez et al.   BIOMATERIALS

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

(2010) Cheul Cho et al.   BIOTECHNIQUES

The 12th–14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

(2010) Mikaël M. Martino et al.   FASEB JOURNAL

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells

(2010) Ying Mei et al.   NATURE MATERIALS

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function

(2010) Taihei Ito et al.   TRANSPLANTATION

Cell cycle control of mammalian neural stem cells: putting a speed limit on G1

(2010) Paolo Salomoni et al.   TRENDS IN CELL BIOLOGY

Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells

(2009) Terje Sjöström et al.   Acta Biomaterialia

Artificial Stem Cell Niches

(2009) Matthias P. Lutolf et al.   ADVANCED MATERIALS

The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells

(2009) Manus J.P. Biggs et al.   BIOMATERIALS

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis

(2009) William P. Daley et al.   DEVELOPMENTAL BIOLOGY

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins

(2009) C. Ostlund et al.   JOURNAL OF CELL SCIENCE

Through-mask anodization of titania dot- and pillar-like nanostructures on bulk Ti substrates using a nanoporous anodic alumina mask

(2009) Terje Sjöström et al.   NANOTECHNOLOGY

E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells

(2009) Jean-Leon Chong et al.   NATURE

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Prospects for Stem Cell-Based Therapy

(2008) George Q. Daley et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

(2008) Elisabetta Ada Cavalcanti‐Adam et al.   HFSP Journal

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

(2008) Mark A. LaBarge et al.   Integrative Biology

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

Functional immobilization of signaling proteins enables control of stem cell fate

(2008) Kristin Alberti et al.   NATURE METHODS

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The β integrins and cytoskeletal nanoimprinting

(2007) Mairead A. Wood et al.   EXPERIMENTAL CELL RESEARCH

No place like home: anatomy and function of the stem cell niche

(2007) D. Leanne Jones et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY