Recent Advances of Utilizing Artificial Intelligence in Lab on a Chip for Diagnosis and Treatment

An outlook on microfluidics: the promise and the challenge

(2022) Sarah Battat et al.   LAB ON A CHIP

Proteomics technologies for cancer liquid biopsies

(2022) Zhiyong Ding et al.   Molecular Cancer

Artificial intelligence-based microfluidic platforms for the sensitive detection of environmental pollutants: Recent advances and prospects

(2022) Niki Pouyanfar et al.   Trends in Environmental Analytical Chemistry

The future of Artificial Intelligence for the BioTech Big Data landscape

(2022) Fausto Artico et al.   CURRENT OPINION IN BIOTECHNOLOGY

Analysis and comparison of machine learning methods for blood identification using single-cell laser tweezer Raman spectroscopy

(2022) Yiming Liu et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Enhancing Clinical Translation of Cancer Using Nanoinformatics

(2021) Madjid Soltani et al.   Cancers

Microfluidic platform for synthesis and optimization of chitosan-coated magnetic nanoparticles in cisplatin delivery

(2021) Saeed Siavashy et al.   CARBOHYDRATE POLYMERS

A new era in functional genomics screens

(2021) Laralynne Przybyla et al.   NATURE REVIEWS GENETICS

Data Harmonization for Heterogeneous Datasets: A Systematic Literature Review

(2021) Ganesh Kumar et al.   Applied Sciences-Basel

Recent Progress in Intelligent Wearable Sensors for Health Monitoring and Wound Healing Based on Biofluids

(2021) Siyang Cheng et al.   Frontiers in Bioengineering and Biotechnology

Precision cardiovascular medicine: artificial intelligence and epigenetics for the pathogenesis and prediction of coarctation in neonates

(2020) Ray O. Bahado-Singh et al.   Journal of Maternal-Fetal & Neonatal Medicine

Implementing machine learning methods for imaging flow cytometry

(2020) Sadao Ota et al.   Microscopy

A neural network approach for real-time particle/cell characterization in microfluidic impedance cytometry

(2020) Carlos Honrado et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Intelligent image-based deformation-assisted cell sorting with molecular specificity

(2020) Ahmad Ahsan Nawaz et al.   NATURE METHODS

Image-Based Single Cell Sorting Automation in Droplet Microfluidics

(2020) Muhsincan Sesen et al.   Scientific Reports

Intelligent classification of platelet aggregates by agonist type

(2020) Yuqi Zhou et al.   eLife

Integrative Analysis and Machine Learning based Characterization of Single Circulating Tumor Cells

(2020) Arvind Iyer et al.   Journal of Clinical Medicine

Potential, challenges and future directions for deep learning in prognostics and health management applications

(2020) Olga Fink et al.   ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE

Object detection in real time based on improved single shot multi-box detector algorithm

(2020) Ashwani Kumar et al.   EURASIP Journal on Wireless Communications and Networking

The state of the art of deep learning models in medical science and their challenges

(2020) Chandradeep Bhatt et al.   MULTIMEDIA SYSTEMS

Deep learning-based light scattering microfluidic cytometry for label-free acute lymphocytic leukemia classification

(2020) Jing Sun et al.   Biomedical Optics Express

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

(2020) Mohammadmahdi Mobaraki et al.   Pharmaceutics

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

(2020) Farshad Moradi Kashkooli et al.   Nano Today

A novel numerical modeling paradigm for bio particle tracing in non-inertial microfluidics devices

(2019) Amirali Ebadi et al.   MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

A gentle introduction to deep learning in medical image processing

(2019) Andreas Maier et al.   Zeitschrift fur Medizinische Physik

Convolutional neural network for cell classification using microscope images of intracellular actin networks

(2019) Ronald Wihal Oei et al.   PLoS One

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

Biotechnology, Big Data and Artificial Intelligence

(2019) Arlindo L. Oliveira   Biotechnology Journal

Machine Learning Based Real‐Time Image‐Guided Cell Sorting and Classification

(2019) Yi Gu et al.   CYTOMETRY PART A

Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles

(2019) Fei Tian et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Application of Microfluidic Chips in Separation and Analysis of Extracellular Vesicles in Liquid Biopsy for Cancer

(2019) Jin Lu et al.   Micromachines

Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning

(2019) Karan Ahuja et al.   Microsystems & Nanoengineering

Deep learning for the classification of human sperm

(2019) Jason Riordon et al.   COMPUTERS IN BIOLOGY AND MEDICINE

TOP-GAN: Stain-free cancer cell classification using deep learning with a small training set

(2019) Moran Rubin et al.   MEDICAL IMAGE ANALYSIS

Dielectrophoresis-based microfluidic platform to sort micro-particles in continuous flow

(2019) Mohsen Hajari et al.   MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS

Robust Microfabrication of Highly Parallelized Three-Dimensional Microfluidics on Silicon

(2019) Sagar Yadavali et al.   Scientific Reports

Cell Separations and Sorting

(2019) Malgorzata A. Witek et al.   ANALYTICAL CHEMISTRY

Microfluidic systems for cancer diagnostics

(2019) Jose L Garcia-Cordero et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microfluidic technologies for circulating tumor cell isolation

(2018) Hyungseok Cho et al.   ANALYST

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

(2018) Martin Widschwendter et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combinatorial drug discovery in nanoliter droplets

(2018) Anthony Kulesa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

(2018) Eduardo Reátegui et al.   Nature Communications

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

(2018) Wenshuo Wang et al.   Advanced Healthcare Materials

Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data

(2018) Dana E. Orange et al.   Arthritis & Rheumatology

Profiling circulating tumour cells and other biomarkers of invasive cancers

(2018) Mahla Poudineh et al.   Nature Biomedical Engineering

Intelligent Image-Activated Cell Sorting

(2018) Nao Nitta et al.   CELL

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

(2018) Marinka Zitnik et al.   Information Fusion

A Fluorescent Biosensors for Detection Vital Body Fluids’ Agents

(2018) Witold Nawrot et al.   SENSORS

Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis, and Drug Delivery

(2018) Chao Liu et al.   ADVANCED MATERIALS

Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles

(2018) Wenzhe Li et al.   ADVANCED MATERIALS

High-performance medicine: the convergence of human and artificial intelligence

(2018) Eric J. Topol   NATURE MEDICINE

Deep Learning with Microfluidics for Biotechnology

(2018) Jason Riordon et al.   TRENDS IN BIOTECHNOLOGY

AI Paradigms for Teaching Biotechnology

(2018) Wilson Wen Bin Goh et al.   TRENDS IN BIOTECHNOLOGY

iTRAQ-based quantitative tissue proteomic analysis of differentially expressed proteins (DEPs) in non-transgenic and transgenic soybean seeds

(2018) Weixiao Liu et al.   Scientific Reports

Artificial intelligence in healthcare

(2018) Kun-Hsing Yu et al.   Nature Biomedical Engineering

Recent advances in microfluidic cell sorting systems

(2018) Yigang Shen et al.   SENSORS AND ACTUATORS B-CHEMICAL

High-throughput microfluidic imaging flow cytometry

(2018) Stavros Stavrakis et al.   CURRENT OPINION IN BIOTECHNOLOGY

Recent developments of microfluidics as a tool for biotechnology and microbiology

(2018) Ott Scheler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Machine learning for epigenetics and future medical applications

(2017) Lawrence B. Holder et al.   Epigenetics

Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design

(2017) W. L. Ung et al.   LAB ON A CHIP

Integration and application of optical chemical sensors in microbioreactors

(2017) Pia Gruber et al.   LAB ON A CHIP

Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy

(2017) Yiyue Jiang et al.   LAB ON A CHIP

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

(2017) Olivier Y. F. Henry et al.   LAB ON A CHIP

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

(2017) Karel Domansky et al.   Microfluidics and Nanofluidics

Current and Emerging Applications of Droplet Digital PCR in Oncology

(2017) Susana Olmedillas-López et al.   Molecular Diagnosis & Therapy

Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes

(2017) Kevin Drew et al.   Molecular Systems Biology

High-purity capture and release of circulating exosomes using an exosome-specific dual-patterned immunofiltration (ExoDIF) device

(2017) Yoon-Tae Kang et al.   Nanoscale

Sorting cells by their density

(2017) Nazila Norouzi et al.   PLoS One

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma

(2017) Mark Kalinich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell epigenomics: Recording the past and predicting the future

(2017) Gavin Kelsey et al.   SCIENCE

High-throughput automated microfluidic sample preparation for accurate microbial genomics

(2017) Soohong Kim et al.   Nature Communications

RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes

(2017) Joseph Abatemarco et al.   Nature Communications

Development of a facile droplet-based single-cell isolation platform for cultivation and genomic analysis in microorganisms

(2017) Qiang Zhang et al.   Scientific Reports

Network-assisted target identification for haploinsufficiency and homozygous profiling screens

(2017) Sheng Wang et al.   PLoS Computational Biology

Disease Prediction by Machine Learning Over Big Data From Healthcare Communities

(2017) Min Chen et al.   IEEE Access

Mechanical strain sensing implicated in cell shape recovery in Escherichia coli

(2017) Felix Wong et al.   Nature Microbiology

Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences

(2017) Daniel T. Chiu et al.   Chem

3D Bioprinting for Tissue and Organ Fabrication

(2016) Yu Shrike Zhang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Weakly supervised learning of biomedical information extraction from curated data

(2016) Suvir Jain et al.   BMC BIOINFORMATICS

Cytopathological image analysis using deep-learning networks in microfluidic microscopy

(2016) G. Gopakumar et al.   JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION

Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating

(2016) Peng Zhang et al.   LAB ON A CHIP

Review: imaging technologies for flow cytometry

(2016) Yuanyuan Han et al.   LAB ON A CHIP

Droplet microfluidics for microbiology: techniques, applications and challenges

(2016) Tomasz S. Kaminski et al.   LAB ON A CHIP

Automated droplet measurement (ADM): an enhanced video processing software for rapid droplet measurements

(2016) Zhuang Zhi Chong et al.   Microfluidics and Nanofluidics

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

From profiles to function in epigenomics

(2016) Stefan H. Stricker et al.   NATURE REVIEWS GENETICS

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

(2016) James Che et al.   Oncotarget

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production

(2016) Chia-Wen Tsao   Micromachines

Deep Learning in Label-free Cell Classification

(2016) Claire Lifan Chen et al.   Scientific Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

(2015) Majid Ebrahimi Warkiani et al.   Annual Review of Biomedical Engineering

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

A microfluidic chip integrated with a high-density PDMS-based microfiltration membrane for rapid isolation and detection of circulating tumor cells

(2015) Xiaoyun Fan et al.   BIOSENSORS & BIOELECTRONICS

On-chip quantitative detection of pathogen genes by autonomous microfluidic PCR platform

(2015) Hiroaki Tachibana et al.   BIOSENSORS & BIOELECTRONICS

Framework for morphometric classification of cells in imaging flow cytometry

(2015) G. GOPAKUMAR et al.   JOURNAL OF MICROSCOPY

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

(2015) C. Wyatt Shields IV et al.   LAB ON A CHIP

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Machine learning applications in cancer prognosis and prediction

(2015) Konstantina Kourou et al.   Computational and Structural Biotechnology Journal

Continuous Distributed Representation of Biological Sequences for Deep Proteomics and Genomics

(2015) Ehsaneddin Asgari et al.   PLoS One

Drug repositioning by integrating target information through a heterogeneous network model

(2014) Wenhui Wang et al.   BIOINFORMATICS

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

The power of social media analytics

(2014) Weiguo Fan et al.   COMMUNICATIONS OF THE ACM

A sensitive microfluidic platform for a high throughput DNA methylation assay

(2014) Maria Ronen et al.   LAB ON A CHIP

The intersection of flow cytometry with microfluidics and microfabrication

(2014) Menake E. Piyasena et al.   LAB ON A CHIP

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Artificial intelligence-based classification of breast cancer using cellular images

(2014) Rajesh Kumar Tripathy et al.   RSC Advances

Integrative Analysis of Many Weighted Co-Expression Networks Using Tensor Computation

(2014) Wenyuan Li et al.   PLoS Computational Biology

Mesenchymal stem cells: a new trend for cell therapy

(2013) Xin Wei et al.   ACTA PHARMACOLOGICA SINICA

Exploration of microfluidic devices based on multi-filament threads and textiles: A review

(2013) A. Nilghaz et al.   Biomicrofluidics

Advances in high-throughput single-cell microtechnologies

(2013) Westbrook M Weaver et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Multiplexed living cells stained with quantum dot bioprobes for multiplexed detection of single-cell array

(2013) Dahai Ren et al.   JOURNAL OF BIOMEDICAL OPTICS

Recent advancements in chemical luminescence-based lab-on-chip and microfluidic platforms for bioanalysis

(2013) Mara Mirasoli et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Probing cellular heterogeneity in cytokine-secreting immune cells using droplet-based microfluidics

(2013) Venkatachalam Chokkalingam et al.   LAB ON A CHIP

Droplet morphometry and velocimetry (DMV): a video processing software for time-resolved, label-free tracking of droplet parameters

(2013) Amar S. Basu   LAB ON A CHIP

Size-selective collection of circulating tumor cells using Vortex technology

(2013) Elodie Sollier et al.   LAB ON A CHIP

Single-cell analysis and sorting using droplet-based microfluidics

(2013) Linas Mazutis et al.   Nature Protocols

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

Artificial Intelligence in Medicine and Cardiac Imaging: Harnessing Big Data and Advanced Computing to Provide Personalized Medical Diagnosis and Treatment

(2013) Steven E. Dilsizian et al.   Current Cardiology Reports

Relating drug-protein interaction network with drug side effects

(2012) S. Mizutani et al.   BIOINFORMATICS

Predicting sample size required for classification performance

(2012) Rosa L Figueroa et al.   BMC Medical Informatics and Decision Making

Programmable large area digital microfluidic array with integrated droplet sensing for bioassays

(2012) B. Hadwen et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Optical imaging techniques for point-of-care diagnostics

(2012) Hongying Zhu et al.   LAB ON A CHIP

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Micropatterning and Its Applications in Biomedical Research*

(2012) Da-Hai REN et al.   PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Gaussian interaction profile kernels for predicting drug–target interaction

(2011) Twan van Laarhoven et al.   BIOINFORMATICS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supervised prediction of drug–target interactions using bipartite local models

(2009) Kevin Bleakley et al.   BIOINFORMATICS

Innovations in optical microfluidic technologies for point-of-care diagnostics

(2008) Frank B. Myers et al.   LAB ON A CHIP

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE