Network-assisted target identification for haploinsufficiency and homozygous profiling screens

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy

(2016) Rohith Srivas et al.   MOLECULAR CELL

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Functional genomics to uncover drug mechanism of action

(2015) Sebastian M B Nijman   Nature Chemical Biology

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

(2014) Livnat Jerby-Arnon et al.   CELL

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

Building high-resolution synthetic lethal networks: a ‘Google map’ of the cancer cell

(2014) James M. Paul et al.   TRENDS IN MOLECULAR MEDICINE

Genetic Interaction Networks: Toward an Understanding of Heritability

(2013) Anastasia Baryshnikova et al.   Annual Review of Genomics and Human Genetics

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

(2013) Dominic Hoepfner et al.   MICROBIOLOGICAL RESEARCH

Predicting drug–target interactions through integrative analysis of chemogenetic assays in yeast

(2013) Marja A. Heiskanen et al.   Molecular BioSystems

STITCH 4: integration of protein–chemical interactions with user data

(2013) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

Systematic identification of gene annotation errors in the widely used yeast mutation collections

(2012) Taly Ben-Shitrit et al.   NATURE METHODS

Discovering the Targets of Drugs Via Computational Systems Biology: FIGURE 1.

(2011) Hon Nian Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bugs, drugs and chemical genomics

(2011) Terry Roemer et al.   Nature Chemical Biology

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

(2010) Laura Kapitzky et al.   Molecular Systems Biology

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

A survey of yeast genomic assays for drug and target discovery

(2010) Andrew M. Smith et al.   PHARMACOLOGY & THERAPEUTICS

Systematic discovery of nonobvious human disease models through orthologous phenotypes

(2010) K. L. McGary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Docking for fragment inhibitors of AmpC  -lactamase

(2009) D. G. Teotico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae

(2008) S. G. Addinall et al.   GENETICS

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Targeting and tinkering with interaction networks

(2008) Robert B Russell et al.   Nature Chemical Biology

An integrated platform of genomic assays reveals small-molecule bioactivities

(2008) Shawn Hoon et al.   Nature Chemical Biology

Defining genetic interaction

(2008) R. Mani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

(2008) M. Gustavsson et al.   RNA

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE