A global genetic interaction network maps a wiring diagram of cellular function

Design and synthesis of a minimal bacterial genome

(2016) C. A. Hutchison et al.   SCIENCE

Modeling Microbial Growth Curves with GCAT

(2015) Yury V. Bukhman et al.   BioEnergy Research

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis

(2015) Yolanda T. Chong et al.   CELL

Plant-derived antifungal agent poacic acid targets β-1,3-glucan

(2015) Jeff S. Piotrowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

(2015) Joshua S. Bloom et al.   Nature Communications

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes

(2015) Megan Kofoed et al.   G3-Genes Genomes Genetics

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

(2015) J. L. Y. Koh et al.   G3-Genes Genomes Genetics

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

(2015) Peter Tsvetkov et al.   eLife

A map of directional genetic interactions in a metazoan cell

(2015) Bernd Fischer et al.   eLife

Therapeutics Based on Stop Codon Readthrough

(2014) Kim M. Keeling et al.   Annual Review of Genomics and Human Genetics

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

Unbiased Screening of Marine Sponge Extracts for Anti-inflammatory Agents Combined with Chemical Genomics Identifies Girolline as an Inhibitor of Protein Synthesis

(2013) Shan-Yu Fung et al.   ACS Chemical Biology

A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer

(2013) R. Deshpande et al.   CANCER RESEARCH

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast

(2013) D. A. Skelly et al.   GENOME RESEARCH

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

(2013) Dominic Hoepfner et al.   MICROBIOLOGICAL RESEARCH

A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome

(2013) T. Srikumar et al.   Molecular Systems Biology

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

(2013) Christie M Buchovecky et al.   NATURE GENETICS

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

An efficient method for genome-wide polyadenylation site mapping and RNA quantification

(2013) Stefan Wilkening et al.   NUCLEIC ACIDS RESEARCH

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

(2013) Leo C. K. Wan et al.   NUCLEIC ACIDS RESEARCH

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Comparison of Profile Similarity Measures for Genetic Interaction Networks

(2013) Raamesh Deshpande et al.   PLoS One

Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes

(2013) P. A. Gibney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

Construction of a microbial natural product library for chemical biology studies

(2012) Naoki Kato et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

(2012) Mohan Babu et al.   NATURE

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation

(2012) Farzin Khosrow-Khavar et al.   G3-Genes Genomes Genetics

Conserved rules govern genetic interaction degree across species

(2012) Elizabeth N Koch et al.   GENOME BIOLOGY

Reconstitution of CF IA from Overexpressed Subunits Reveals Stoichiometry and Provides Insights into Molecular Topology

(2011) James M. B. Gordon et al.   BIOCHEMISTRY

Putting genetic interactions in context through a global modular decomposition

(2011) Jeremy Bellay et al.   GENOME RESEARCH

iProphet: Multi-level Integrative Analysis of Shotgun Proteomic Data Improves Peptide and Protein Identification Rates and Error Estimates

(2011) David Shteynberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Predicting phenotypic variation in yeast from individual genome sequences

(2011) Rob Jelier et al.   NATURE GENETICS

Structure and function of the GINS complex, a key component of the eukaryotic replisome

(2010) Stuart A. MacNeill   BIOCHEMICAL JOURNAL

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae

(2010) Joris J. Benschop et al.   MOLECULAR CELL

Genetic interactions reveal the evolutionary trajectories of duplicate genes

(2010) Benjamin VanderSluis et al.   Molecular Systems Biology

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

The BioGRID Interaction Database: 2011 update

(2010) C. Stark et al.   NUCLEIC ACIDS RESEARCH

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

Rewiring of Genetic Networks in Response to DNA Damage

(2010) S. Bandyopadhyay et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Pre-mRNA 3′-end processing complex assembly and function

(2010) Serena Chan et al.   Wiley Interdisciplinary Reviews-RNA

Bidirectional promoters generate pervasive transcription in yeast

(2009) Zhenyu Xu et al.   NATURE

Population genomics of domestic and wild yeasts

(2009) Gianni Liti et al.   NATURE

InParanoid 7: new algorithms and tools for eukaryotic orthology analysis

(2009) G. Ostlund et al.   NUCLEIC ACIDS RESEARCH

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

(2009) K. J. McManus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae

(2008) S. G. Addinall et al.   GENETICS

Global Screening of Genes Essential for Growth in High-Pressure and Cold Environments: Searching for Basic Adaptive Strategies Using a Yeast Deletion Library

(2008) F. Abe et al.   GENETICS

Toward a Comprehensive Temperature-Sensitive Mutant Repository of the Essential Genes of Saccharomyces cerevisiae

(2008) Shay Ben-Aroya et al.   MOLECULAR CELL

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

(2008) S. J. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network

(2008) H. Yu et al.   SCIENCE

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

(2008) A. Roguev et al.   SCIENCE

An in Vivo Map of the Yeast Protein Interactome

(2008) K. Tarassov et al.   SCIENCE

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY

Functional Maps of Protein Complexes from Quantitative Genetic Interaction Data

(2008) Sourav Bandyopadhyay et al.   PLoS Computational Biology

A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection

(2008) Amanda Greenall et al.   GENOME BIOLOGY