Article
Chemistry, Analytical
Mohamed Sharafeldin, Jason J. Davis
Summary: The development of diagnostic devices relies on the immobilization of biomolecules to generate quantifiable signals. The selectivity and sensitivity of biosensors depend on the interfacial properties, which can be analyzed using characterization techniques.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Alba Calatayud-Sanchez, Sara Caicedo de la Arada, Yara Alvarez-Brana, Fernando Benito-Lopez, Lourdes Basabe-Desmonts
Summary: Understanding cell affinity is crucial for disease research, drug development, and cell biology studies. Existing techniques for measuring cell affinity are either expensive and complex, or indirect and time-consuming. This study presents a microfluidic device integrated with a cell-based biosensing platform to monitor cell affinity in real-time. The device successfully quantifies and differentiates the affinity of stem cells towards various molecules. It offers a self-contained, user-friendly, and single-use solution for quantifying cell affinity with multiple applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biochemical Research Methods
Khalid E. Alzahrani, Abdulaziz K. Assaifan, Mahmoud Al-Gawati, Abdullah M. Alswieleh, Hamad Albrithen, Abdullah Alodhayb
Summary: A microcantilever-based biosensor functionalised with the UL83-antibody of HCMV has been developed for the detection of UL83-antigen of HCMV. The system shows low detection limit and short detection time, with high selectivity for the UL83-HCMV antigen.
IET NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Andre Moreira, Sara Madeira, Mihaela Buciumeanu, Joana Fialho, Angela Carvalho, Filipe Silva, Fernando J. Monteiro, Joao Carames
Summary: The use of zirconia as an alternative biomaterial for titanium implants has been increasing due to its biocompatibility and favorable aesthetic features. This study focused on designing silica coatings with micropatterns to promote effective osseointegration. The results showed that the micropatterned coatings, especially the lines micropattern, exhibited improved hydrophilicity and integrity, making them promising surfaces for enhanced bone formation after implant insertion.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Roland Hager, Christian Forsich, Jiri Duchoslav, Christoph Burgstaller, David Stifter, Julian Weghuber, Peter Lanzerstorfer
Summary: Polymeric materials have emerged as important components in biosensing interfaces, providing superior surfaces for biomolecule binding and printing. This study characterized 11 different polymer foils and evaluated their suitability for surface functionalization, biomolecule micropatterning, and fluorescence microscopy. Results showed that COC, COP, and PMMA were the most promising alternatives to glass coverslips, demonstrating excellent applicability in subcellular micropatterning experiments.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ziyang Huang, Siyi Zou, Guozhen Liu
Summary: This study presents a simple method to modify the surface of eutectic gallium-indium (EGaIn) with p-aniline derivatives, introducing a monolayer of organic molecules with versatile functional groups. The modified EGaIn nanoparticles exhibit antioxidizing properties, increased conductivity, and good distribution in both ethanol and aqueous solutions. These nanoparticles can be further functionalized with biomolecules for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Ken C. Pradel, Naoki Fukata
Summary: Since 2012, the performance and efficiency of triboelectric nanogenerators have been improving continuously by adding nanostructures to increase surface area and charge transfer. By enhancing our understanding of surface interactions in TENG, smarter optimization methods can be applied to reduce costs and enhance performance.
Article
Nanoscience & Nanotechnology
Takane Tsuchii, Kazuki Kaneko, Kenta Morita, Takashi Nishino, Tatsuo Maruyama
Summary: Fluorous chemistry was used to achieve rewritable surface functionalization of plastic substrates, enabling the successful study of the effects of fluoropolymer and Rf-amine molecular structures on surface immobilization. This approach showed potential for diverse applications and could be used for micropatterning of biomolecules on plastic surfaces through microcontact printing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Urandelger Tuvshindorj, Vanessa Trouillet, Aliaksei Vasilevich, Britta Koch, Steven Vermeulen, Aurelie Carlier, Morgan R. Alexander, Stefan Giselbrecht, Roman Truckenmuller, Jan de Boer
Summary: A high-throughput screening platform called Galapagos chip is developed to study the geometric aspects of cell-ECM interaction.
Article
Chemistry, Physical
Suemeyra Vural Kaymaz, Hediyeh Malekzadsani Nobar, Hasan Sarigul, Caner Soylukan, Lalehan Akyuz, Meral Yuce
Summary: Surface-functionalized nanostructures play a crucial role in biotechnology with applications in biosensors, drug delivery, therapy, and bioimaging. This review provides an overview of widely used surface modification strategies and discusses the application-focused landscape in four key domains: therapeutics, biosensing, environmental monitoring, and point-of-care technologies. The insights presented in this review serve as a useful guide for both beginners and professionals, promoting further innovations at the intersection of nanotechnology and biotechnology.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biochemical Research Methods
Soonjong Roh, Yerim Jang, Jin Yoo, Hyejeong Seong
Summary: Surface modification techniques are crucial in biomedical applications for their direct response to the biological environment. Physical and chemical modification techniques have been extensively studied, with a focus on achieving uniform and conformal surface coverage on target geometries for sensor and biomedical applications.
Article
Chemistry, Physical
Jihyeon Kim, Seonhwa Park, Haesik Yang
Summary: Electrochemical signals can be affected by the presence of iron oxide magnetic particles, which act as adaptable redox reservoirs and enhance current. This finding is significant for electrochemical detection.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Miranji Katta, R. Sandanalakshmi
Summary: As Lab-on-Chip platforms continue to develop, the use of micro-and nano-dimensions for biosensors using miniaturized cantilevers increases. However, computational mathematics often overlooks the influence of temperature. In Nano-Electro-Mechanical-Systems, temperature becomes a dominant factor due to the higher surface-to-volume ratio. This study presents a simple analytical technique for controlling bimetallic cantilevers with NEMS-based sensing and actuation mechanisms, incorporating temperature and material attributes.
KUWAIT JOURNAL OF SCIENCE
(2023)
Article
Chemistry, Analytical
Shuo Yin, Aipeng Chen, Xiaoni Fang, Peng Zhang, Chaoyong Yang
Summary: This article introduces a method for simultaneous detection of MMP14 expression and MMP14 proteolytic activity using a fluorescent nanosensor based on a spherical aptamer/peptide dual-probe strategy. The proposed sensor outperforms traditional methods in terms of analytical performances, and has successfully been applied for the detection of exosomal MMP14 from cell culture media and real serum samples. The increased levels of MMP14 expression and proteolytic activity in serum from cancer patients indicate the potential of this method as biomarkers in liquid biopsy for disease diagnosis and real-time surveillance.
Article
Engineering, Electrical & Electronic
Wei Tang, Ying Fu, Yukun Huang, Yuanzhe Li, Yawen Song, Xin Xi, Yude Yu, Yuezeng Su, Feng Yan, Xiaojun Guo
Summary: Developing organic field-effect transistor (OFET) biosensors for customizable biomarker detection is an important and cost-effective tool for biological studies and clinical diagnosis. This study establishes design principles for OFET biosensors, highlighting key parameters like steep subthreshold swing, proper threshold voltage, bias-stress stability, and mechanical durability that enhance the transconductance efficiency and signal-to-noise ratio. The research also demonstrates the successful implementation of a label-free OFET biosensor for detecting miR-21 with high selectivity and low detection limit.
NPJ FLEXIBLE ELECTRONICS
(2022)