Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage

TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways

(2021) Yan Zhou et al.   Cell Death & Disease

PDK4 decrease neuronal apoptosis via inhibiting ROS-ASK1/p38 pathway in early brain injury after subarachnoid hemorrhage

(2021) xuan gao et al.   ANTIOXIDANTS & REDOX SIGNALING

Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells

(2021) Karina Sánchez‐Alegría et al.   FASEB JOURNAL

Brain insulin signalling in metabolic homeostasis and disease

(2021) Thomas Scherer et al.   Nature Reviews Endocrinology

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice

(2021) Liangyu Peng et al.   Frontiers in Aging Neuroscience

Oxygen-glucose deprivation in neurons: implications for cell transplantation therapies

(2021) Sebastiano Antonio Rizzo et al.   PROGRESS IN NEUROBIOLOGY

Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage

(2020) Yucong Peng et al.   Journal of Neuroinflammation

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage

(2019) Fabio S. Taccone et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

How reliable is cerebral blood flow to map changes in neuronal activity?

(2019) Clotilde Lecrux et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats

(2019) Carmen D Tekwe et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

(2019) Qiyu Tian et al.   AGING CELL

DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage

(2019) Tao Tao et al.   Journal of Neuroinflammation

α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

(2019) Xiongjun Wang et al.   MOLECULAR CELL

Fifty Shades of α-Ketoglutarate on Cellular Programming

(2019) Giusy Di Conza et al.   MOLECULAR CELL

Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway

(2019) Pingan Wu et al.   AMINO ACIDS

Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4

(2018) J. Pearson-Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Targeting pericytes for therapeutic approaches to neurological disorders

(2018) Jinping Cheng et al.   ACTA NEUROPATHOLOGICA

Glutaminolysis Epigenetically Regulates Anti-Apoptotic Gene Expression in IPF Fibroblasts

(2018) Le Bai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Spontaneous subarachnoid haemorrhage

(2017) R Loch Macdonald et al.   LANCET

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Insulin resistance in Alzheimer's disease

(2017) Thomas Diehl et al.   Translational Research

The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

(2016) Dingfu Xiao et al.   AMINO ACIDS

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats

(2016) Wanchun You et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

(2013) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Beta-Cell Dysfunction and Insulin Resistance after Subarachnoid Haemorrhage

(2011) N.D. Kruyt et al.   NEUROENDOCRINOLOGY

Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms

(2010) Yi Liu et al.   CANCER LETTERS

Hyperglycemia in Aneurysmal Subarachnoid Hemorrhage: A Potentially Modifiable Risk Factor for Poor Outcome

(2010) Nyika D Kruyt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM