Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms
Authors
Keywords
-
Journal
JOURNAL OF ENDOCRINOLOGY
Volume 220, Issue 2, Pages T1-T23
Publisher
Bioscientifica
Online
2013-11-27
DOI
10.1530/joe-13-0327
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Origins and Drivers of Insulin Resistance
- (2013) Andrew M.F. Johnson et al. CELL
- Direct Autocrine Action of Insulin on -Cells: Does It Make Physiological Sense?
- (2013) C. J. Rhodes et al. DIABETES
- Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38 MAPK During Insulin Resistance
- (2013) Y. Qi et al. DIABETES
- Hepatic ERK activity plays a role in energy metabolism
- (2013) Ping Jiao et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The role of FOXO1 in β-cell failure and type 2 diabetes mellitus
- (2013) Tadahiro Kitamura Nature Reviews Endocrinology
- Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
- (2013) T. Galbo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conservation and divergence in the transcriptional programs of the human and mouse immune systems
- (2013) T. Shay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FoxO6 in glucose metabolism (FoxO6在葡萄糖代谢中的作用)
- (2013) Dae Hyun Kim et al. Journal of Diabetes
- Inflammation during obesity is not all bad: evidence from animal and human studies
- (2012) Jianping Ye et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease
- (2012) Christian Rask-Madsen et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets
- (2012) Giulio R. Romeo et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
- (2012) Hongxia Ren et al. CELL
- Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
- (2012) Chutima Talchai et al. CELL
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle
- (2012) Deborah M. Muoio et al. Cell Metabolism
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action
- (2012) Marianna Sadagurski et al. Cell Metabolism
- FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis
- (2012) Kyoichiro Tsuchiya et al. Cell Metabolism
- RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium
- (2012) Angela F. Messmer-Blust et al. CIRCULATION RESEARCH
- FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development
- (2012) Arunima Sengupta et al. DEVELOPMENTAL DYNAMICS
- Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity
- (2012) R. V. Cohen et al. DIABETES CARE
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
- (2012) K. D. Copps et al. DIABETOLOGIA
- The Foxo Family: Partners in Crime or Silent Heroes
- (2012) Jennifer L. Estall ENDOCRINOLOGY
- NF-κB Essential Modifier Is Required for Hepatocyte Proliferation and the Oval Cell Reaction After Partial Hepatectomy in Mice
- (2012) Yann Malato et al. GASTROENTEROLOGY
- Bariatric Surgery and Long-term Cardiovascular Events
- (2012) Lars Sjöström et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance
- (2012) Eun Ju Bae et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
- (2012) Pavan K. Battiprolu et al. JOURNAL OF CLINICAL INVESTIGATION
- Bariatric surgery for type 2 diabetes
- (2012) John B Dixon et al. LANCET
- Central nervous system control of metabolism
- (2012) Martin G. Myers et al. NATURE
- Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
- (2012) Atsuhiko Ichimura et al. NATURE
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
- (2012) Pontus Boström et al. NATURE
- Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
- (2012) Mingjian Lu et al. NATURE MEDICINE
- Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
- (2012) Durba Pal et al. NATURE MEDICINE
- Regulation of Metabolism: A Cross Talk Between Gut Microbiota and Its Human Host
- (2012) Rémy Burcelin PHYSIOLOGY
- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
- (2012) J. L. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Host-Gut Microbiota Metabolic Interactions
- (2012) J. K. Nicholson et al. SCIENCE
- Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation
- (2011) Ryan G. Holzer et al. CELL
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
- (2011) Maria M. Mihaylova et al. CELL
- RETRACTED: Impairment of Central Leptin-Mediated PI3K Signaling Manifested as Hepatic Steatosis Independent of Hyperphagia and Obesity
- (2011) James P. Warne et al. Cell Metabolism
- Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice
- (2011) Alexander S. Banks et al. Cell Metabolism
- Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16
- (2011) Yuta Takahashi et al. Cell Metabolism
- Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
- (2011) Tetsuya Kubota et al. Cell Metabolism
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
- (2011) Dae Hyun Kim et al. DIABETES
- Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
- (2011) Y. Lee et al. DIABETES
- IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
- (2011) David R. Whiting et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice
- (2011) Kebin Zhang et al. ENDOCRINOLOGY
- Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes
- (2011) Hua V. Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
- (2011) Olivier Bezy et al. JOURNAL OF CLINICAL INVESTIGATION
- IDF's view of bariatric surgery in type 2 diabetes
- (2011) Paul Zimmet et al. LANCET
- Human nutrition, the gut microbiome and the immune system
- (2011) Andrew L. Kau et al. NATURE
- A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism
- (2011) Arlee Fafalios et al. NATURE MEDICINE
- Myocardial AKT: The Omnipresent Nexus
- (2011) Mark A. Sussman et al. PHYSIOLOGICAL REVIEWS
- Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
- (2011) N. Kumashiro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
- (2011) E. Gonzalez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Obesity, insulin resistance and free fatty acids
- (2011) Guenther Boden Current Opinion in Endocrinology Diabetes and Obesity
- Excess exposure to insulin may be the primary cause of insulin resistance
- (2010) Wenhong Cao et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Metabolic Surgery to Treat Type 2 Diabetes: Clinical Outcomes and Mechanisms of Action
- (2010) Francesco Rubino et al. Annual Review of Medicine
- Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
- (2010) Keertik Fulzele et al. CELL
- Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
- (2010) Mathieu Ferron et al. CELL
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
- (2010) Da Young Oh et al. CELL
- Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity
- (2010) Kyle L. Hoehn et al. Cell Metabolism
- Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice
- (2010) Christian Rask-Madsen et al. Cell Metabolism
- Heart Disease and Stroke Statistics—2011 Update
- (2010) Véronique L. Roger et al. CIRCULATION
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
- (2010) A. Kumar et al. DIABETES
- Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
- (2010) J. Jager et al. DIABETOLOGIA
- FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress
- (2010) Arunima Sengupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
- (2010) Zhidan Wu et al. JOURNAL OF CLINICAL INVESTIGATION
- Lipid-induced insulin resistance: unravelling the mechanism
- (2010) Varman T Samuel et al. LANCET
- Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
- (2010) Y. C. Long et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
- (2010) Shomit Sengupta et al. MOLECULAR CELL
- Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
- (2010) Shijie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin enhances glucose-stimulated insulin secretion in healthy humans
- (2010) C. Bouche et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
- (2010) Y. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
- (2009) Christian Pehmøller et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction
- (2009) Jian Xu et al. CIRCULATION
- Human IL6 enhances leptin action in mice
- (2009) M. Sadagurski et al. DIABETOLOGIA
- The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation
- (2009) R. K. Simmons et al. DIABETOLOGIA
- Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia
- (2009) Hui-Yu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling
- (2009) Zengqiang Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner
- (2009) Scott W. Wong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
- (2009) Arunima Sengupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)
- (2009) Hui-Yu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry
- (2009) Devanand Kowlessur et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
- (2009) Marie-Therese Rached et al. JOURNAL OF CLINICAL INVESTIGATION
- The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis
- (2009) S. Guo et al. MOLECULAR AND CELLULAR BIOLOGY
- The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
- (2009) Leona Plum et al. NATURE MEDICINE
- Foxo1 integrates insulin signaling with mitochondrial function in the liver
- (2009) Zhiyong Cheng et al. NATURE MEDICINE
- Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes
- (2008) Safina Ali et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?
- (2008) MeiShiue Kuo et al. BIOCHIMIE
- Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
- (2008) Xiaocheng C. Dong et al. Cell Metabolism
- The Emerging Genetic Architecture of Type 2 Diabetes
- (2008) Alessandro Doria et al. Cell Metabolism
- Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
- (2008) Sudha B. Biddinger et al. Cell Metabolism
- Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding
- (2008) Naoto Kubota et al. Cell Metabolism
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- Selective versus Total Insulin Resistance: A Pathogenic Paradox
- (2008) Michael S. Brown et al. Cell Metabolism
- Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors
- (2008) Heather J. Evans-Anderson et al. CIRCULATION RESEARCH
- Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
- (2008) E. R. Duncan et al. DIABETES
- The Metabolic Syndrome
- (2008) Marc-Andre Cornier et al. ENDOCRINE REVIEWS
- An Integrated View of Insulin Resistance and Endothelial Dysfunction
- (2008) Ranganath Muniyappa et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- O-GlcNAc Regulates FoxO Activation in Response to Glucose
- (2008) Michael P. Housley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PP2A Regulates the Pro-apoptotic Activity of FOXO1
- (2008) Ling Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2
- (2008) Jin Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle
- (2008) Eric B. Taylor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt
- (2008) Kazuyuki Yamagata et al. MOLECULAR CELL
- Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injury
- (2007) Weidong Chai et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started