Targeting pericytes for therapeutic approaches to neurological disorders

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization

(2018) Lila Khennouf et al.   BRAIN

Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2

(2018) Nils J G Rorsman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Brain pericyte activation occurs early in Huntington's disease

(2018) Thomas Padel et al.   EXPERIMENTAL NEUROLOGY

β-Adrenergic receptor agonists attenuate pericyte loss in diabetic retinas through Akt activation

(2018) Jang-Hyuk Yun et al.   FASEB JOURNAL

PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia

(2018) Jie Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia

(2018) Ravi L. Rungta et al.   NEURON

Topographic Reorganization of Cerebrovascular Mural Cells under Seizure Conditions

(2018) Margarita Arango-Lievano et al.   Cell Reports

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

(2018) Luis Alarcon-Martinez et al.   eLife

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes secrete pro-regenerative molecules in response to platelet-derived growth factor-BB

(2017) Abderahim Gaceb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Proliferating NG2-Cell-Dependent Angiogenesis and Scar Formation Alter Axon Growth and Functional Recovery After Spinal Cord Injury in Mice

(2017) Zoe C. Hesp et al.   JOURNAL OF NEUROSCIENCE

Loss of Pericytes in Radiation Necrosis after Glioblastoma Treatments

(2017) Soon-Tae Lee et al.   MOLECULAR NEUROBIOLOGY

Pericytes impair capillary blood flow and motor function after chronic spinal cord injury

(2017) Yaqing Li et al.   NATURE MEDICINE

A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging

(2017) Eyiyemisi C Damisah et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Plastic roles of pericytes in the blood–retinal barrier

(2017) Do Young Park et al.   Nature Communications

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

(2017) Martin Teichert et al.   Nature Communications

Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth

(2017) Chern Ein Oon et al.   Oncotarget

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

(2017) Alerie Guzman De La Fuente et al.   Cell Reports

Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

(2017) Fergus M O'Farrell et al.   eLife

Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy

(2017) Rocio Leal-Campanario et al.   Scientific Reports

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

(2016) Ian Gopal Gould et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

(2016) Huanjiao Jenny Zhou et al.   NATURE MEDICINE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease

(2016) Thomas Padel et al.   NEUROBIOLOGY OF DISEASE

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis

(2016) Ling Guo et al.   Experimental and Therapeutic Medicine

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

(2016) Yunlong Yang et al.   Nature Communications

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Analysis of the brain mural cell transcriptome

(2016) Liqun He et al.   Scientific Reports

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Aberrant astrocytes impair vascular reactivity in Huntington disease

(2015) Han-Yun Hsiao et al.   ANNALS OF NEUROLOGY

Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System

(2015) Rieko Muramatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson’s disease patients

(2015) Gesine Paul et al.   JOURNAL OF CLINICAL INVESTIGATION

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

(2015) Pia Rantakari et al.   NATURE IMMUNOLOGY

Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury

(2015) Y. Zhu et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes

(2015) Abhay P. Sagare et al.   NEUROSCIENCE LETTERS

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

(2015) Takayuki Nakagomi et al.   STEM CELLS

Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes

(2015) G. B. Schulz et al.   STROKE

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations

(2015) Natalie M. Kofler et al.   Scientific Reports

Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

(2015) David A. Hartmann et al.   Neurophotonics

Endogenous Brain Pericytes Are Widely Activated and Contribute to Mouse Glioma Microvasculature

(2015) Andreas Svensson et al.   PLoS One

Brain pericytes acquire a microglial phenotype after stroke

(2014) Ilknur Özen et al.   ACTA NEUROPATHOLOGICA

Retinal Microangiopathy in a Mouse Model of Inducible Mural Cell Loss

(2014) Cammi N. Valdez et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin 2 Induces Pericyte Apoptosis via  3 1 Integrin Signaling in Diabetic Retinopathy

(2014) S. W. Park et al.   DIABETES

Thalidomide Ameliorates Inflammation and Vascular Injury but Aggravates Tubular Damage in the Irradiated Mouse Kidney

(2014) Marion Scharpfenecker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Capillary Transit Time Heterogeneity and Flow-Metabolism Coupling after Traumatic Brain Injury

(2014) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A role for human brain pericytes in neuroinflammation

(2014) Deidre Jansson et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pericyte Dynamics during Angiogenesis: New Insights from New Identities

(2014) Peter C. Stapor et al.   JOURNAL OF VASCULAR RESEARCH

Cilostazol attenuates ischemia–reperfusion-induced blood–brain barrier dysfunction enhanced by advanced glycation endproducts via transforming growth factor-β1 signaling

(2014) Tomonori Takeshita et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury

(2014) Alice Gaudin et al.   Nature Nanotechnology

Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus

(2014) Sebastien Milesi et al.   NEUROBIOLOGY OF DISEASE

Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord

(2014) Elizabeth A. Gozal et al.   Frontiers in Neural Circuits

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

(2013) Andrew L. Davies et al.   ANNALS OF NEUROLOGY

Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes

(2013) J. Ruan et al.   BLOOD

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Notch3 establishes brain vascular integrity by regulating pericyte number

(2013) Y. Wang et al.   DEVELOPMENT

Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β

(2013) B. Shao et al.   DIABETES OBESITY & METABOLISM

The Role of the Microcirculation in Delayed Cerebral Ischemia and Chronic Degenerative Changes after Subarachnoid Hemorrhage

(2013) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex

(2013) J. C. Fordsmann et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?

(2013) M. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation

(2013) Yoshio Omote et al.   JOURNAL OF NEUROSCIENCE RESEARCH

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Advanced glycation end-products disrupt the blood–brain barrier by stimulating the release of transforming growth factor–β by pericytes and vascular endothelial growth factor and matrix metalloproteinase–2 by endothelial cells in vitro

(2013) Fumitaka Shimizu et al.   NEUROBIOLOGY OF AGING

A Novel In Vitro Model to Study Pericytes in the Neurovascular Unit of the Developing Cortex

(2013) Christoph M. Zehendner et al.   PLoS One

Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity

(2013) V. Chintalgattu et al.   Science Translational Medicine

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra

(2013) Anil Zechariah et al.   STROKE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

(2012) Marisa Karow et al.   Cell Stem Cell

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone

(2012) B. Lacar et al.   JOURNAL OF NEUROSCIENCE

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification

(2012) G. Nicolas et al.   NEUROLOGY

Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease

(2012) Maria Björkqvist et al.   PLoS One

Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter

(2011) T. Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS

(2011) Min Dai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma

(2011) Jed A. Hartings et al.   BRAIN

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

(2011) Xu Cui et al.   NEUROBIOLOGY OF DISEASE

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

The 140-kDa Protein of Blood-Brain Barrier-Associated Pericytes Is Identical to Aminopeptidase N

(2010) Jörg Kunz et al.   JOURNAL OF NEUROCHEMISTRY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain

(2010) Govindaiah Vinukonda et al.   STROKE

CNS pericytes: Concepts, misconceptions, and a way out

(2009) Martin Krueger et al.   GLIA

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

(2008) Sven Christian et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8

(2008) N. A. Abdel-Malak et al.   BLOOD

Pericytes: Pluripotent Cells of the Blood Brain Barrier

(2008) Paula Dore-Duffy   CURRENT PHARMACEUTICAL DESIGN

Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-α in an animal model of inflamed Alzheimer’s disease brain

(2007) Jae K. Ryu et al.   NEUROBIOLOGY OF DISEASE