The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

The role of leucine and its metabolites in protein and energy metabolism

(2015) Yehui Duan et al.   AMINO ACIDS

The interaction between glutamine and the mTOR pathway in ovarian cancer cell proliferation and metabolism

(2015) D.R. Roque et al.   GYNECOLOGIC ONCOLOGY

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation

(2015) Joshua K. Salabei et al.   STEM CELLS

l-Glutamine deprivation induces autophagy and alters the mTOR and MAPK signaling pathways in porcine intestinal epithelial cells

(2014) Yuhua Zhu et al.   AMINO ACIDS

l-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK

(2014) Dan Yi et al.   AMINO ACIDS

Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs

(2014) Weiwei Wang et al.   AMINO ACIDS

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

(2014) Lorena Pochini et al.   Frontiers in Chemistry

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

(2013) Séverine Lorin et al.   Autophagy

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

(2013) D. J. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle

(2013) Arthur J. L. Cooper et al.   METABOLIC BRAIN DISEASE

l-Glutamine regulates amino acid utilization by intestinal bacteria

(2012) Zhao-Lai Dai et al.   AMINO ACIDS

Deprive to kill

(2012) Simone Cardaci et al.   Autophagy

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1

(2012) S. Cardaci et al.   CANCER RESEARCH

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Effects of combined maternal administration with alpha-ketoglutarate (AKG) and β-hydroxy-β-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring

(2012) Marcin R Tatara et al.   Nutrition & Metabolism

Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions

(2012) Wojciech Rzeski et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional Amino Acids in Growth, Reproduction, and Health

(2012) Guoyao Wu   Advances in Nutrition

Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells

(2011) Kang Yao et al.   AMINO ACIDS

The structure and allosteric regulation of mammalian glutamate dehydrogenase

(2011) Ming Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H2O2—Implications for their role in disease, especially cancer

(2011) Simon P. J. Albracht et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets

(2010) Yongqing Hou et al.   AMINO ACIDS

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

(2010) Aaron L. McLain et al.   FREE RADICAL RESEARCH

Regulation of protein metabolism by glutamine: implications for nutrition and health

(2010) Pengbin Xi   Frontiers in Bioscience-Landmark

Alpha-Ketoglutarate and intestinal function

(2010) Yongqing Hou   Frontiers in Bioscience-Landmark

TRIENNIAL GROWTH SYMPOSIUM: Important roles for L-glutamine in swine nutrition and production1,2

(2010) G. Wu et al.   JOURNAL OF ANIMAL SCIENCE

Transamination Is Required for α-Ketoisocaproate but Not Leucine to Stimulate Insulin Secretion

(2010) Yingsheng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

(2010) Daniel A. Tennant et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

(2010) Andrew Y. Choo et al.   MOLECULAR CELL

The structure and allosteric regulation of glutamate dehydrogenase

(2010) Ming Li et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolism and functions of l-glutamate in the epithelial cells of the small and large intestines

(2009) François Blachier et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children

(2009) Charles A Stanley   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic fate and function of dietary glutamate in the gut

(2009) Douglas G Burrin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

(2009) C. Yang et al.   CANCER RESEARCH

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

(2009) Ken Matsumoto et al.   CANCER SCIENCE

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

(2008) Francesca Frigerio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Three-dimensional culture for monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles

(2008) Suthasinee Nilsang et al.   BIOTECHNOLOGY PROGRESS

Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis

(2008) Stefania Carobbio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular aspects of tumour hypoxia

(2008) Saskia E. Rademakers et al.   Molecular Oncology

Effect of dietary alpha‐ketoglutarate on blood lipid profile during hypercholesterolaemia in rats

(2008) Radoslaw P. Radzki et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Dietary α-ketoglutarate reduces gastrectomy-evoked loss of calvaria and trabecular bone in female rats

(2008) Piotr J. Dobrowolski et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY