Senescence and cancer — role and therapeutic opportunities

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

(2022) Boshi Wang et al.   EMBO JOURNAL

CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal

(2022) Lisa Crozier et al.   EMBO JOURNAL

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence

(2021) Marina Kolesnichenko et al.   EMBO JOURNAL

Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence

(2021) Cihangir Duy et al.   Cancer Discovery

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

(2021) Christopher D. Wiley et al.   Cell Metabolism

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

(2021) Sandra Benítez et al.   DEVELOPMENTAL CELL

Anti-Cancer Treatment Strategies in the Older Population: Time to Test More?

(2021) Antonino C. Tralongo et al.   GERIATRICS

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

(2021) Thijmen van Vliet et al.   MOLECULAR CELL

Inhibition of CDK4/6 promotes CD8 T-cell memory formation

(2021) Max Heckler et al.   Cancer Discovery

Emerging strategies to target RAS signaling in human cancer therapy

(2021) Kun Chen et al.   Journal of Hematology & Oncology

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

(2021) Sebastian Igelmann et al.   MOLECULAR CELL

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

Senolytics reduce coronavirus-related mortality in old mice

(2021) Christina D. Camell et al.   SCIENCE

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer

(2021) Heidie Frisco Cabanos et al.   Cancers

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

(2021) Koichiro Kawaguchi et al.   iScience

Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial

(2021) Francesco Di Pierro et al.   International Journal of General Medicine

Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study

(2021) Francesco Di Pierro et al.   International Journal of General Medicine

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

(2021) Eliot Fletcher-Sananikone et al.   CANCER RESEARCH

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

(2021) Christos P. Zampetidis et al.   MOLECULAR CELL

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

(2021) Ines Sturmlechner et al.   SCIENCE

Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma

(2021) Ulrike Schoetz et al.   Cell Death & Disease

Autophagy drives fibroblast senescence through MTORC2 regulation

(2020) Monique Bernard et al.   Autophagy

Accelerated aging in breast cancer survivors and its association with mortality and cancer recurrence

(2020) Jingjing Zhu et al.   BREAST CANCER RESEARCH AND TREATMENT

Therapy-Induced Senescence Drives Bone Loss

(2020) Zhangting Yao et al.   CANCER RESEARCH

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

(2020) Birgit Ritschka et al.   GENES & DEVELOPMENT

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

(2020) Liam D. Cassidy et al.   Nature Communications

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Autophagy regulation as a promising approach for improving cancer immunotherapy

(2020) Nestor Ishimwe et al.   CANCER LETTERS

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

Frailty and aging in cancer survivors

(2020) Kirsten K. Ness et al.   Translational Research

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X L –BAX interaction

(2020) Tareq Saleh et al.   Molecular Oncology

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

AP-1 imprints a reversible transcriptional programme of senescent cells

(2020) Ricardo Iván Martínez-Zamudio et al.   NATURE CELL BIOLOGY

Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16 INK4a and frailty

(2020) Andrew B. Smitherman et al.   CANCER

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

(2020) Satotaka Omori et al.   Cell Metabolism

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

(2020) Maurice Reimann et al.   BLOOD

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

(2020) Ilaria Guccini et al.   CANCER CELL

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Lysosomal trapping of palbociclib and its functional implications

(2019) Susana Llanos et al.   ONCOGENE

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

(2019) Chien-Hsiang Hsu et al.   CELL

CCN1-Induced Cellular Senescence Promotes Heart Regeneration

(2019) Teng Feng et al.   CIRCULATION

Transient p53-Mediated Regenerative Senescence in the Injured Heart

(2019) Rachel Sarig et al.   CIRCULATION

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

(2019) Hubert Fleury et al.   Nature Communications

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

p21 in Cancer Research

(2019) Shamloo et al.   Cancers

A review of canakinumab and its therapeutic potential for non-small cell lung cancer

(2019) Kara M. Schenk et al.   ANTI-CANCER DRUGS

Inducing and exploiting vulnerabilities for the treatment of liver cancer

(2019) Cun Wang et al.   NATURE

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation

(2019) Amy E Schade et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

(2018) Yong Yu et al.   CANCER CELL

The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E 2 intracrine pathway

(2018) Johanna Cormenier et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

(2018) Aled J. Parry et al.   Nature Communications

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

(2018) Sofia Ferreira-Gonzalez et al.   Nature Communications

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

(2018) Bhavna Murali et al.   CANCER RESEARCH

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Effects of novel HDAC inhibitors on urothelial carcinoma cells

(2018) Aline Kaletsch et al.   Clinical Epigenetics

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

(2018) Michalis Mastri et al.   Cell Reports

Identification of senescent cell surface targetable protein DPP4

(2017) Kyoung Mi Kim et al.   GENES & DEVELOPMENT

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE)

(2017) Nickhill Bhakta et al.   LANCET

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

(2016) Shom Goel et al.   CANCER CELL

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis

(2016) Yuejuan Li et al.   MATRIX BIOLOGY

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth

(2016) Xiangnan Guan et al.   MOLECULAR CANCER RESEARCH

CD20-Targeting Immunotherapy Promotes Cellular Senescence in B-Cell Lymphoma

(2016) J. H. M. Da britz et al.   MOLECULAR CANCER THERAPEUTICS

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Meta-analysis reveals that hydraulic traits explain cross-species patterns of drought-induced tree mortality across the globe

(2016) William R. L. Anderegg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1)

(2016) Marco Perez et al.   Oncotarget

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development

(2016) Xianmin Luo et al.   Cell Reports

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells

(2015) Shin-ichiro Takebayashi et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

(2015) Olivier Pluquet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

(2015) Dauren Alimbetov et al.   BIOGERONTOLOGY

Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies

(2015) W. Hu et al.   CLINICAL CANCER RESEARCH

Senescent cells communicate via intercellular protein transfer

(2015) Anat Biran et al.   GENES & DEVELOPMENT

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Capillary muscle

(2015) Caroline Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Siltuximab (CNTO 328): a promising option for human malignancies

(2015) Bao-An Chen et al.   Drug Design Development and Therapy

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells

(2015) Maria Peiris-Pagès et al.   Oncotarget

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

(2015) Dina Dikovskaya et al.   Cell Reports

Frailty in childhood cancer survivors

(2014) Kirsten K. Ness et al.   CANCER

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

(2014) Hanna K. Sanoff et al.   JNCI-Journal of the National Cancer Institute

The Inflammatory Chemokine CCL5 and Cancer Progression

(2014) Donatella Aldinucci et al.   MEDIATORS OF INFLAMMATION

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Characterization of novel markers of senescence and their prognostic potential in cancer

(2014) M Althubiti et al.   Cell Death & Disease

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Health-related quality of life and symptoms in patients with myelofibrosis treated with ruxolitinibversusbest available therapy

(2013) Claire N. Harrison et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells

(2013) Yu Zhu et al.   CANCER SCIENCE

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

(2012) Celia Quijano et al.   CELL CYCLE

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ- Myc Lymphoma by Restoring Oncogene-Induced Senescence

(2012) Meaghan Wall et al.   Cancer Discovery

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Opposing roles of NF- B in anti-cancer treatment outcome unveiled by cross-species investigations

(2011) H. Jing et al.   GENES & DEVELOPMENT

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Inhibition of VEGF induces cellular senescence in colorectal cancer cells

(2011) Mohammad R. Hasan et al.   INTERNATIONAL JOURNAL OF CANCER

Caveolin-1, cellular senescence and age-related diseases

(2011) Huafei Zou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Cellular senescence predicts treatment outcome in metastasised colorectal cancer

(2010) A M Haugstetter et al.   BRITISH JOURNAL OF CANCER

A chemotherapy-associated senescence bystander effect in breast cancer cells

(2010) Xu Di et al.   CANCER BIOLOGY & THERAPY

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

(2010) Maurice Reimann et al.   CANCER CELL

Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo

(2010) S. Takeuchi et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL

(2010) J J Kim et al.   CELL DEATH AND DIFFERENTIATION

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Premature senescence induced by DNA demethylating agent (Decitabine) as therapeutic option for malignant pleural mesothelioma

(2010) S. Amatori et al.   LUNG CANCER

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Epigenetic modulation of gene expression of human leukemia cell lines – induction of cell death and senescence

(2010) K. ELKNEROVA et al.   NEOPLASMA

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis

(2009) D. Eyman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirolimus and Everolimus Induce Endothelial Cellular Senescence Via Sirtuin 1 Down-Regulation

(2009) Hidetaka Ota et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

IL-6, but not IFN-γ, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing

(2009) G Regis et al.   LEUKEMIA

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH