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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

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p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

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Circumventing senescence is associated with stem cell properties and metformin sensitivity

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Next-generation characterization of the Cancer Cell Line Encyclopedia

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Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression

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α-Ketoglutarate links p53 to cell fate during tumour suppression

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Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner

(2019) Xavier H. Mascle et al.   STRUCTURE

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

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ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis

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Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection

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Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

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ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data

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Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

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Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

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Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival

(2017) Boxi Zhang et al.   Journal of Cancer

Interactions of AMTN, ODAM and SCPPPQ1 proteins of a specialized basal lamina that attaches epithelial cells to tooth mineral

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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

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From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

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Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency

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Substrate channelling as an approach to cascade reactions

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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

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The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

(2016) Xiaomu Li et al.   Nature Communications

Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome

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The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

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A roadmap for interpreting 13 C metabolite labeling patterns from cells

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STAT3 regulated ARF expression suppresses prostate cancer metastasis

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A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

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Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes

(2014) Everardo Macias et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

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The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence

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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

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Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

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Cytosolic malate dehydrogenase regulates senescence in human fibroblasts

(2012) Seung-Min Lee et al.   BIOGERONTOLOGY

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

(2012) C. Mantel et al.   BLOOD

Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells

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Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

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Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3

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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

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Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

(2008) Song Xiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stat3 and c-Myc Genome-Wide Promoter Occupancy in Embryonic Stem Cells

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