Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice

(2021) Koichiro Kawaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction

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Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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Senolytics improve physical function and increase lifespan in old age

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Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

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Elimination of p19ARF -expressing cells protects against pulmonary emphysema in mice

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Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

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Cellular senescence drives age-dependent hepatic steatosis

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Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

Cellular Senescence: A Translational Perspective

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN-p53-MDM2 Axis

(2014) S. M. Brouxhon et al.   MOLECULAR CANCER THERAPEUTICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IL-6 Secreted from Senescent Mesenchymal Stem Cells Promotes Proliferation and Migration of Breast Cancer Cells

(2014) Guo-hu Di et al.   PLoS One

Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

(2013) S. M. Brouxhon et al.   CLINICAL CANCER RESEARCH

Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling

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Dishonorable Discharge: The Oncogenic Roles of Cleaved E-Cadherin Fragments

(2012) J. M. David et al.   CANCER RESEARCH

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor☆

(2011) Landon J. Inge et al.   EXPERIMENTAL CELL RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Epidemiology and treatment of melanoma in elderly patients

(2010) Susan Tsai et al.   Nature Reviews Clinical Oncology

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

(2008) A Jeanes et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY