Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Exploring and exploiting the systemic effects of deregulated replication licensing

(2016) Theodoros G. Petrakis et al.   SEMINARS IN CANCER BIOLOGY

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of microhomology in genomic structural variation

(2014) Diego Ottaviani et al.   TRENDS IN GENETICS

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

(2013) K. J. Neelsen et al.   GENES & DEVELOPMENT

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

The Shotgun Proteomic Study of the Human ThinPrep Cervical Smear Using iTRAQ Mass-Tagging and 2D LC-FT-Orbitrap-MS: The Detection of the Human Papillomavirus at the Protein Level

(2013) Evaggelia K. Papachristou et al.   JOURNAL OF PROTEOME RESEARCH

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells

(2013) C Delehouzé et al.   ONCOGENE

Genomic Instability in Cancer

(2013) T. Abbas et al.   Cold Spring Harbor Perspectives in Biology

Regulation of E2F1 by APC/CCdh1via K11 linkage-specific ubiquitin chain formation

(2012) Varija Budhavarapu et al.   CELL CYCLE

p21WAF1 and tumourigenesis

(2012) Noel A. Warfel et al.   CURRENT OPINION IN ONCOLOGY

Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

(2012) Andrew J Holland et al.   NATURE MEDICINE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

(2012) I Murfuni et al.   ONCOGENE

Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone

(2012) Ismail Iraqui et al.   PLoS Genetics

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

(2011) Maria Sideridou et al.   JOURNAL OF CELL BIOLOGY

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

(2011) Stine Jørgensen et al.   JOURNAL OF CELL BIOLOGY

APC/CCdc20targets E2F1 for degradation in prometaphase

(2010) Melissa J. Peart et al.   CELL CYCLE

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

(2010) Halfdan Beck et al.   JOURNAL OF CELL BIOLOGY

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of the E2F1-Driven Cancer Cell Fate by the DNA Damage Response Machinery and Potential Novel E2F1 Targets in Osteosarcomas

(2009) Michalis Liontos et al.   AMERICAN JOURNAL OF PATHOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

DNA lesions sequestered in micronuclei induce a local defective-damage response

(2009) Mariona Terradas et al.   DNA REPAIR

p57KIP2: "Kip"ing the Cell under Control

(2009) I. S. Pateras et al.   MOLECULAR CANCER RESEARCH

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

BreakDancer: an algorithm for high-resolution mapping of genomic structural variation

(2009) Ken Chen et al.   NATURE METHODS

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Rad51 Protein Controls Rad52-mediated DNA Annealing

(2008) Yun Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Preventing DNA over-replication: a Cdk perspective

(2008) Andrew CG Porter   Cell Division