Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis

Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD3-containing scaffolds

(2022) Xiao Xiao et al.   CHEMICAL COMMUNICATIONS

Difluoromethylarylation of α, β- Unsaturated Amides via a Photocatalytic Radical Smiles Rearrangement

(2022) W. Dolbier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphine-Catalyzed Sequential [3 + 2]/[3 + 2] Annulation between Allenoates and Arylidenemalononitriles for the Enantioselective Construction of Bicyclo[3,3,0]octenes and Cyclopenta[c]quinolinones

(2022) Nengzhong Wang et al.   ORGANIC LETTERS

Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis

(2022) Guang-Jian Mei et al.   Chem

The Rational Design and Atroposelective Synthesis of Axially Chiral C2‐Arylpyrrole‐Derived Amino Alcohols

(2022) Tian‐Jiao Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications

(2021) Osamu Kitagawa   ACCOUNTS OF CHEMICAL RESEARCH

N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C‐N Axial Chirality

(2021) Tingting Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Formation of Quaternary Centers by Allylic Alkylation with First-Row Transition-Metal Catalysts

(2021) Lars Süsse et al.   CHEMICAL REVIEWS

NHC‐Catalyzed Desymmetrization of N‐Aryl Maleimides Leading to the Atroposelective Synthesis of N‐Aryl Succinimides

(2021) Soumen Barik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Access to Axially and Centrally Chiral Sulfinamides via Asymmetric Allylic Alkylation

(2021) Gaoliang Zheng et al.   ORGANIC LETTERS

Carbene-Catalyzed Atroposelective Annulation and Desymmetrization of Urazoles

(2021) Jiamiao Jin et al.   ORGANIC LETTERS

An axial-to-axial chirality transfer strategy for atroposelective construction of C–N axial chirality

(2021) Ze-Shui Liu et al.   Chem

Sotorasib: First Approval

(2021) Hannah A. Blair   DRUGS

Copper-Catalyzed Regioselective 1,4-Selenosulfonylation of 1,3-Enynes to Access Cyanoalkylsulfonylated Allenes

(2021) Fu-Sheng He et al.   ORGANIC LETTERS

Enantioselective Nickel-Catalyzed Hydrocyanative Desymmetrization of Norbornene Derivatives

(2021) Feilong Sun et al.   ACS Catalysis

Enantioselective Synthesis of Axially Chiral Sulfonamides via Atroposelective Hydroamination of Allenes

(2021) Zeng Gao et al.   ACS Catalysis

Enantioselective and Diastereoselective C–H Alkylation of Benzamides: Synergized Axial and Central Chirality via a Single Stereodetermining Step

(2021) Jinlei Wang et al.   ACS Catalysis

Rational design and atroposelective synthesis of N–N axially chiral compounds

(2021) Guang-Jian Mei et al.   Chem

Atroposelective sp 3 C—H Coupling for Kinetic Resolution of Thioanilide Atropisomers

(2021) Hua‐Jie Jiang et al.   CHINESE JOURNAL OF CHEMISTRY

Pd(II)-Catalyzed Atroposelective C–H Allylation: Synthesis of Enantioenriched N-Aryl Peptoid Atropisomers

(2021) Zhen-Sheng Jia et al.   ORGANIC LETTERS

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

(2021) Fei Cheng et al.   ORGANIC LETTERS

Asymmetric Synthesis of Axially Chiral Phosphamides via Atroposelective N-Allylic Alkylation

(2020) Guo-Hui Yang et al.   ACS Catalysis

N ‐Heterocyclic carbene organocatalysis: activation modes and typical reactive intermediates

(2020) Xingkuan Chen et al.   CHINESE JOURNAL OF CHEMISTRY

Asymmetric Synthesis of Axially Chiral Anilides via Organocatalytic Atroposelective N-Acylation

(2020) Dawei Li et al.   ORGANIC LETTERS

Isothiourea-Catalyzed Atroposelective N-Acylation of Sulfonamides

(2020) Jun-Yang Ong et al.   ORGANIC LETTERS

Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides

(2020) Xing-Wei Gu et al.   Nature Communications

Catalytic Enantioselective Functionalizations of C–H Bonds by Chiral Iridium Complexes

(2020) Łukasz Woźniak et al.   CHEMICAL REVIEWS

Enantioselective Synthesis of Atropisomeric Anilides via Pd(II)-Catalyzed Asymmetric C–H Olefination

(2020) Qi-Jun Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Asymmetric Organomulticatalysis

(2020) Xiao Xiao et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C–N Coupling

(2019) Xiaozhong Fan et al.   ACS Catalysis

Organocatalytic Desymmetrization Reactions for the Synthesis of Axially Chiral Compounds

(2019) Nicola Di Iorio et al.   CHEMICAL RECORD

Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation

(2019) Honghe Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals

(2019) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C—H Activation

(2019) Qi Zhang et al.   CHINESE JOURNAL OF CHEMISTRY

Catalytic Enantioselective Synthesis of N-C Axially Chiral Sulfonamides through Chiral Palladium-catalyzed N-Allylation

(2019) Yuki Kikuchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

(2019) He-Yuan Bai et al.   Nature Communications

Practical access to axially chiral sulfonamides and biaryl amino phenols via organocatalytic atroposelective N-alkylation

(2019) Shenci Lu et al.   Nature Communications

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Atropisomerism in medicinal chemistry: challenges and opportunities

(2018) Sean T Toenjes et al.   Future Medicinal Chemistry

Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones

(2018) Jennifer M. Crawford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

(2018) Tyler G. Saint-Denis et al.   SCIENCE

Synthesis of Axially Chiral C–N Scaffolds via Asymmetric Coupling with Enantiopure Sulfinyl Iodanes

(2018) James Rae et al.   ACS Catalysis

Atroposelective Catalytic Asymmetric Allylic Alkylation Reaction for Axially Chiral Anilides with Achiral Morita–Baylis–Hillman Carbonates

(2018) Shou-Lei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote Control of Axial Chirality: Synthesis of Spirooxindole–Urazoles via Desymmetrization of ATAD

(2018) Lin-Lin Zhang et al.   ORGANIC LETTERS

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2018) Qiang Cheng et al.   CHEMICAL REVIEWS

Michael Addition of Oxindoles to N-(2-tert-Butylphenyl)maleimides: Efficient Desymmetrization for the Synthesis of Atropisomeric Succinimides with Quaternary and Tertiary Stereocenters

(2017) Giorgio Bencivenni et al.   SYNTHESIS-STUTTGART

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

(2017) Yong-Bin Wang et al.   Nature Communications

Tale of Twisted Molecules. Atropselective Photoreactions: Taming Light Induced Asymmetric Transformations through Non-biaryl Atropisomers

(2016) Elango Kumarasamy et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

(2016) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Silver(I)-Catalyzed Atroposelective Desymmetrization of N-Arylmaleimide via 1,3-Dipolar Cycloaddition of Azomethine Ylides: Access to Octahydropyrrolo[3,4-c]pyrrole Derivatives

(2016) Hua-Chao Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Synthesis of N–C Axially Chiral Mebroqualone and Its Derivatives through Reductive Asymmetric Desymmetrization

(2016) Motohiro Hirai et al.   ORGANIC LETTERS

Targeting remote axial chirality control of N-(2-tert-butylphenyl)succinimides by means of Michael addition type reactions

(2016) Nicola Di Iorio et al.   TETRAHEDRON

Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction

(2016) Ji-Wei Zhang et al.   Nature Communications

An Enantioselective Synthesis of Spirobilactams through Copper-Catalyzed Intramolecular Double N-Arylation and Phase Separation

(2015) Jianguang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in copper-catalyzed asymmetric coupling reactions

(2015) Fengtao Zhou et al.   Beilstein Journal of Organic Chemistry

Catalytic asymmetric desymmetrization of N-arylmaleimides: efficient construction of both atom chirality and axial chirality

(2015) Jianlin Zhang et al.   CHEMICAL COMMUNICATIONS

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives

(2015) Tomoaki Hirata et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination

(2015) Matthew E. Diener et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric synthesis of axially chiral anilides by Pd-catalyzed allylic substitutions with P/olefin ligands

(2015) Yilin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Atroposelective Formal Diels–Alder Desymmetrization of N-Arylmaleimides

(2015) Florine Eudier et al.   ORGANIC LETTERS

Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

(2014) Rui Guo et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of Heterocycles

(2014) Xun-Xiang Guo et al.   CHEMICAL REVIEWS

Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N-Arylmaleimides via Vinylogous Michael Addition

(2014) Nicola Di Iorio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Asymmetric Synthesis of Atropisomeric Compounds with an N‒C Chiral Axis

(2014) Isao Takahashi et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Quantifying and understanding the electronic properties of N-heterocyclic carbenes

(2013) David J. Nelson et al.   CHEMICAL SOCIETY REVIEWS

Phase-Transfer-Catalyzed Asymmetric Synthesis of Axially Chiral Anilides

(2013) Kun Liu et al.   Chemistry-An Asian Journal

Recent development of direct asymmetric functionalization of inert C–H bonds

(2013) Chao Zheng et al.   RSC Advances

Asymmetric Ion-Pairing Catalysis

(2012) Katrien Brak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Copper-Catalyzed Desymmetric Intramolecular Ullmann C–N Coupling: An Enantioselective Preparation of Indolines

(2012) Fengtao Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How easy are the syntheses of allenes?

(2011) Shichao Yu et al.   CHEMICAL COMMUNICATIONS

Iridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Isocyanates

(2011) Gen Onodera et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Synthesis of Axially Chiral o-Iodoanilides by Phase-Transfer Catalyzed Alkylations

(2011) Seiji Shirakawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Brønsted Base-Catalyzed Tandem Isomerization-Michael Reactions of Alkynes: Synthesis of Oxacycles and Azacycles

(2010) Hongjun Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity

(2009) Ramesh Giri et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Protonation of Itaconimides with Thiols and the Rotational Kinetics of the Axially Chiral CN Bond

(2009) Shishi Lin et al.   Chemistry-An Asian Journal

Synthesis of Enantioenriched N-Aryl-2-pyridones with Chiral C-N Axes by Rhodium-Catalyzed [2+2+2] Cycloaddition of Alkynes with Isocyanates

(2008) Ken Tanaka et al.   SYNLETT