Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD3-containing scaffolds

Desulfonylation via Radical Process: Recent Developments in Organic Synthesis

(2021) Xue-Qiang Chu et al.   CHEMICAL REVIEWS

Transition-Metal-Free Reductive Cross-Coupling Employing Metabisulfite as a Connector: General Construction of Alkyl–Alkyl Sulfones

(2021) Yingying Meng et al.   CCS Chemistry

Bioinspired design of a robust d3-methylating agent

(2020) Minyan Wang et al.   Science Advances

Recent Advances in Asymmetric Organomulticatalysis

(2020) Xiao Xiao et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper(I)‐Catalyzed Asymmetric Interrupted Kinugasa Reaction: Synthesis of α‐Thiofunctional Chiral β‐Lactams

(2020) Jialin Qi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

(2019) Zuyuan Shen et al.   ORGANIC LETTERS

Reduction of CO2 with NaBH4/I2 for the Conversion of Thiophenols to Aryl Methyl Sulfides

(2019) Bo Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents

(2019) Ming Wang et al.   Nature Communications

Multicomponent Reductive Cross-Coupling of an Inorganic Sulfur Dioxide Surrogate: Straightforward Construction of Diversely Functionalized Sulfones

(2019) Yingying Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Difluoromethylthioesters from Aldehydes

(2018) Shi-Huan Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate

(2018) Kimihiro Komeyama et al.   ORGANIC LETTERS

Radical difluoromethylthiolation of aromatics enabled by visible light

(2018) Jianbin Li et al.   Chemical Science

Polysulfurating reagent design for unsymmetrical polysulfide construction

(2018) Xiao Xiao et al.   Nature Communications

Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides

(2018) Yi Fang et al.   Nature Communications

Highly mono-selective ortho-methylthiolation of benzamides via cobalt-catalyzed sp2 C–H activation

(2018) Liang Hu et al.   Organic Chemistry Frontiers

Chemical and structural effects of base modifications in messenger RNA

(2017) Emily M. Harcourt et al.   NATURE

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Recent developments in sulfur–carbon bond formation reaction involving thiosulfates

(2017) Zongjun Qiao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

PhSO2SCF2H: A Shelf-Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation

(2016) Dianhu Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Design of a Disulfurating Reagent: Facile and Straightforward Pathway to Unsymmetrical Disulfanes by Copper-Catalyzed Oxidative Cross-Coupling

(2016) Xiao Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible light catalyzed methylsulfoxidation of (het)aryl diazonium salts using DMSO

(2016) Mukund M. D. Pramanik et al.   CHEMICAL COMMUNICATIONS

Pesticide Chemical Research in Toxicology: Lessons from Nature

(2016) John E. Casida et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Unexpected Metabolic Reactions and Secondary Targets of Pesticide Action

(2016) John E. Casida   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

(2016) Kevin W. Kuntz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thioridazine Alters the Cell-Envelope Permeability of Mycobacterium tuberculosis

(2016) Jeroen de Keijzer et al.   JOURNAL OF PROTEOME RESEARCH

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Sulfur atom transfer (SAT) reaction

(2016) Xuefeng Jiang   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transition-metal-free persulfuration to construct unsymmetrical disulfides and mechanistic study of the sulfur redox process

(2015) Xiao Xiao et al.   CHEMICAL COMMUNICATIONS

Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions

(2014) Xiu-Hua Xu et al.   CHEMICAL REVIEWS

Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures

(2014) Brandon R. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Access to 1,4-Benzothiazine: Palladium-Catalyzed Double C–S Bond Formation Using Na2S2O3 as Sulfurating Reagent

(2013) Zongjun Qiao et al.   ORGANIC LETTERS

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents

(2013) Yaoqiu Zhu et al.   ACS Medicinal Chemistry Letters

Control of Oxidative Posttranslational Cysteine Modifications: From Intricate Chemistry to Widespread Biological and Medical Applications

(2011) Claus Jacob et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)

(2011) Anthony M. Giannetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A pictorial representation of zero-point energy and tunnelling contributions to primary hydrogen isotope effects

(2010) R. A. More O'Ferrall   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Stability of ricobendazole in aqueous solutions

(2009) Zimei Wu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The 'wired' universe of organic chemistry

(2009) Bartosz A. Grzybowski et al.   Nature Chemistry