Rational design and atroposelective synthesis of N–N axially chiral compounds

Catalytic and Enantioselective Control of the C−N Stereogenic Axis via the Pictet‐Spengler Reaction

(2021) Ahreum Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Atroposelective Coupling–Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones

(2021) Fan Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides

(2021) Hao Wang et al.   Nature Chemistry

Catalytic Atroposelective Synthesis of N-Aryl Quinoid Compounds

(2020) Sagar D. Vaidya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atroposelective Synthesis of Axially Chiral Styrenes via an Asymmetric C–H Functionalization Strategy

(2020) Liang Jin et al.   Chem

Enantioselective Synthesis of Atropisomers with Multiple Stereogenic Axes

(2020) Xiaoze Bao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Construction of Axially Chiral Indole‐Based Frameworks: An Emerging Area

(2020) Tian-Zhen Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atroposelective Synthesis of Axially Chiral N‐Arylpyrroles by Chiral‐at‐Rhodium Catalysis

(2020) Chen‐Xi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition Metal‐Catalyzed Enantioselective C–H Functionalization via Chiral Transient Directing Group Strategy

(2020) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides

(2020) Xing-Wei Gu et al.   Nature Communications

Atroposelective Access to Oxindole-Based Axially Chiral Styrenes via the Strategy of Catalytic Kinetic Resolution

(2020) Chun Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles

(2019) Lei Zhang et al.   Nature Communications

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

(2019) Yongseok Kwon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Construction of Axially Chiral 2-Arylpyrroles via Chirality Transfer of Atropisomeric Alkenes

(2019) Bin Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical access to axially chiral sulfonamides and biaryl amino phenols via organocatalytic atroposelective N-alkylation

(2019) Shenci Lu et al.   Nature Communications

Rational design, enantioselective synthesis and catalytic applications of axially chiral EBINOLs

(2019) Yong-Bin Wang et al.   Nature Catalysis

Understanding Conformational Preferences of Atropisomeric Hydrazides and Its Influence on Excited State Transformations in Crystalline Media

(2019) Akila Iyer et al.   MOLECULES

Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles

(2019) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C−N Bond-Forming Cross-Coupling and Catalyst-Controlled Atroposelective Cyclodehydration

(2018) Yongseok Kwon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atropisomerism in medicinal chemistry: challenges and opportunities

(2018) Sean T Toenjes et al.   Future Medicinal Chemistry

Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones

(2018) Jennifer M. Crawford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes

(2018) Shiqi Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-Catalyzed Aerobic Oxidative N–N Coupling of Carbazoles and Diarylamines Including Selective Cross-Coupling

(2018) Michael C. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst-Controlled Stereoselective Synthesis of Atropisomers

(2018) Bouthayna Zilate et al.   ACS Catalysis

Synthesis of Enantiopure Isosteres of Amino Acids Containing a Quaternary Stereocenter: Experimental and Computational Evaluation of a Novel Class of Atropisomers

(2018) Paolo Amabili et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Atroposelective Catalytic Asymmetric Allylic Alkylation Reaction for Axially Chiral Anilides with Achiral Morita–Baylis–Hillman Carbonates

(2018) Shou-Lei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Construction of Vicinal Diaxial Styrenes and Multiaxis System via Organocatalysis

(2018) Yu Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal–Knorr Reaction

(2017) Lei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed O-alkylation

(2017) John D. Jolliffe et al.   Nature Chemistry

Organocatalytic atroposelective synthesis of axially chiral styrenes

(2017) Sheng-Cai Zheng et al.   Nature Communications

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

(2017) Yong-Bin Wang et al.   Nature Communications

Stereoselective Arene-Forming Aldol Condensation: Synthesis of Axially Chiral Aromatic Amides

(2016) Vincent C. Fäseke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of axially chiral biaryl compounds by asymmetric catalytic reactions with transition metals

(2016) Pauline Loxq et al.   COORDINATION CHEMISTRY REVIEWS

Stereoselective synthesis of N-arylindoles and related compounds with axially chiral N–C bonds

(2016) Shunsuke Kinoshita et al.   TETRAHEDRON

Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction

(2016) Ji-Wei Zhang et al.   Nature Communications

Highly stable atropisomers by electrophilic amination of a chiral γ-lactam within the synthesis of an elusive conformationally restricted analogue of α-methylhomoserine

(2015) Paolo Amabili et al.   AMINO ACIDS

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

(2015) J. Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Kinetic Resolution of Biaryl Compounds

(2015) Gaoyuan Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination

(2015) Matthew E. Diener et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A twist of nature – the significance of atropisomers in biological systems

(2015) Jamie E. Smyth et al.   NATURAL PRODUCT REPORTS

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N-Arylmaleimides via Vinylogous Michael Addition

(2014) Nicola Di Iorio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spontaneous transfer of chirality in an atropisomerically enriched two-axis system

(2014) Kimberly T. Barrett et al.   NATURE

Asymmetric Synthesis of Atropisomeric Compounds with an N‒C Chiral Axis

(2014) Isao Takahashi et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Natural Products Containing a Nitrogen–Nitrogen Bond

(2013) Lachlan M. Blair et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Synthesis of Atropisomeric Benzamides through Peptide-Catalyzed Bromination

(2013) Kimberly T. Barrett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

(2012) Zhongli Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Induction of chirality: experimental evidence of atropisomerism in azapeptides

(2012) Philipp A. Ottersbach et al.   CHEMICAL COMMUNICATIONS

N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete

(2012) Qingbo Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker

(2012) Hai-Long Jiang et al.   FITOTERAPIA

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

(2011) Steven R. LaPlante et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of chiral biaryl natural products by asymmetric biaryl coupling

(2009) Marisa C. Kozlowski et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of new cycloalkenyliden-pyrroles by domino reaction

(2009) Orazio A. Attanasi et al.   TETRAHEDRON

Transmission of stereochemical information over nanometre distances in chemical reactions

(2008) Jonathan Clayden   CHEMICAL SOCIETY REVIEWS