Enantioselective and Diastereoselective C–H Alkylation of Benzamides: Synergized Axial and Central Chirality via a Single Stereodetermining Step

Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications

(2021) Osamu Kitagawa   ACCOUNTS OF CHEMICAL RESEARCH

NHC‐Catalyzed Desymmetrization of N‐Aryl Maleimides Leading to the Atroposelective Synthesis of N‐Aryl Succinimides

(2021) Soumen Barik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium‐Catalyzed C‐H Activation‐Based Construction of  Axiall and Centrally Chiral Indenes through Two Discrete Insertions

(2021) Xingwei Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxygen‐linked Cyclopentadienyl Rh(III) Complexes‐Catalyzed Asymmetric C−H Arylation of Benzo[h]quinolines with 1‐Diazonaphthoquinones

(2021) Chong-Qing Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Catalytic Synthesis of Atropisomeric o-Terphenyls with 1,2-Diaxes via Axial-to-Axial Diastereoinduction

(2021) Qianwen Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Synthesis of Sulfur-Stereogenic Sulfoximines via Ru(II)-Catalyzed Enantioselective C–H Functionalization Enabled by Chiral Carboxylic Acid

(2021) Tao Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atroposelective Transfer Hydrogenation of Biaryl Aminals via Dynamic Kinetic Resolution. Synthesis of Axially Chiral Diamines

(2021) José A. Carmona et al.   ACS Catalysis

Chiral Carboxylic Acid Assisted Enantioselective C–H Activation with Achiral CpxMIII (M = Co, Rh, Ir) Catalysts

(2021) Tatsuhiko Yoshino et al.   ACS Catalysis

Direct Regio- and Diastereoselective Synthesis of δ -Lactams from Acrylamides and Unactivated Alkenes Initiated by RhIII -Catalyzed C−H Activation

(2020) Sumin Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Axially Chiral Biaryl-2-amines by PdII -Catalyzed Free-Amine-Directed Atroposelective C−H Olefination

(2020) Bei-Bei Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diverse Approaches for Enantioselective C–H Functionalization Reactions Using Group 9 CpxMIII Catalysts

(2020) Tatsuhiko Yoshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ir-Catalyzed Atroposelective Desymmetrization of Heterobiaryls: Hydroarylation of Vinyl Ethers and Bicycloalkenes

(2020) Antonio Romero-Arenas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C–H Arylation of Heteroarenes

(2020) Qui-Hien Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Axially Chiral Biaryl Monophosphine Oxides Enabled by Palladium/WJ-Phos-Catalyzed Asymmetric Suzuki–Miyaura Cross-coupling

(2020) Wangqin Ji et al.   ACS Catalysis

From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C–H Functionalization Reactions

(2020) Qian Shao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hybrid Palladium Catalyst Assembled from Chiral Phosphoric Acid and Thioamide for Enantioselective β‐C(sp 3 )−H Arylation

(2020) Hua‐Jie Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Michael Reaction Inspired Atroposelective Construction of Axially Chiral Biaryls

(2020) Shengyi Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C–H Bond to Aldehydes To Afford Enantioenriched Phthalides

(2020) Wenkun Chen et al.   ORGANIC LETTERS

Transition Metal‐Catalyzed Enantioselective C–H Functionalization via Chiral Transient Directing Group Strategy

(2020) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral cyclopentadienyl ligands: design, syntheses and applications in asymmetric catalysis

(2020) Nicolai Cramer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Chiral Cyclopentadienyl (Cpx) Metal Complexes in Asymmetric Catalysis

(2020) Saad Shaaban et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides

(2020) Xing-Wei Gu et al.   Nature Communications

Asymmetric CpxRh(III)-Catalyzed Acrylic Acid C–H Functionalization with Allenes Provides Chiral γ-Lactones

(2020) Shou-Guo Wang et al.   ACS Catalysis

Construction of axial chirality via palladium/chiral norbornene cooperative catalysis

(2020) Ze-Shui Liu et al.   Nature Catalysis

Palladium-Catalyzed Asymmetric Allylic C–H Functionalization: Mechanism, Stereo- and Regioselectivities, and Synthetic Applications

(2020) Pu-Sheng Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cobalt(III)‐Catalyzed Enantioselective Intermolecular Carboaminations via C‒H Functionalizations

(2020) Nicolai Cramer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Functionalizations of C–H Bonds by Chiral Iridium Complexes

(2020) Łukasz Woźniak et al.   CHEMICAL REVIEWS

Rhodium-Catalyzed Atroposelective Oxidative C–H/C–H Cross-Coupling Reaction of 1-Aryl Isoquinoline Derivatives with Electron-Rich Heteroarenes

(2020) Qiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)–H Activation

(2020) Hojoon Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective C–H Bond Functionalization

(2020) Maria I. Lapuh et al.   ACS Catalysis

Rhodium‐Catalyzed Atroposelective Construction of Indoles via C‐H Bond Activation

(2020) Lincong Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

­Rhodium‐Catalyzed Enantioselective Synthesis of β‐Amino Alcohols via Desymmetrization of gem‐Dimethyl Groups

(2020) Xingwei Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Aminopalladation‐Heck Cascade

(2020) Jieping Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enantioselective CpxRh(III)-Catalyzed C-H Functionalization / Ring-Opening Route to Chiral Cyclopentenylamines

(2019) Nicolai Cramer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C–N Coupling

(2019) Xiaozhong Fan et al.   ACS Catalysis

Ketones and Aldehydes as O-Nucleophiles in Iridium-Catalyzed Intramolecular Asymmetric Allylic Substitution Reaction

(2019) Ye Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branched-Selective Direct α-Alkylation of Cyclic Ketones with Simple Alkenes

(2019) Dong Xing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Biaryl Atropisomers via Pd-Catalyzed C-H Olefination using Chiral Spiro Phosphoric Acid Ligands

(2019) Jun Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation

(2019) Honghe Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals

(2019) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands

(2019) Simon L. Rössler et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium-Catalyzed Atroposelective C–H Arylation: Efficient Synthesis of Axially Chiral Heterobiaryls

(2019) Qiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

(2019) Miaomiao Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of Heteroatom Stereocenters by Enantioselective C–H Functionalization

(2019) Johannes Diesel et al.   ACS Catalysis

Rhodium-Catalyzed Enantioselective Oxidative [3+2] Annulation of Arenes and Azabicyclic Olefins through Twofold C−H Activation

(2019) Ruijie Mi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Alkenyl C−H Functionalization by Cpx RhIII forms 2H -Pyrrol-2-ones through [4+1]-Annulation of Acryl Amides and Allenes

(2019) Shou-Guo Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds

(2019) Yang Yang et al.   Nature Chemistry

Organocatalytic Asymmetric Synthesis of Indole-Based Chiral Heterocycles: Strategies, Reactions, and Outreach

(2019) Yu-Chen Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chiral N-Heterocyclic Carbene Ligands Enable Asymmetric C-H Bond Functionalization

(2019) Olivier Baslé et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-Catalyzed Enantio- and Diastereoselective C−H Cyclopropylation of N-Phenoxylsulfonamides: Combined Experimental and Computational Studies

(2019) Guangfan Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

(2019) Yu-Ping He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Enabled Enantioselective Csp3 -H Activation of Tetrahydroquinolines and Saturated Aza-Heterocycles by RhI

(2018) Steffen Greßies et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to the Enantiopure Axially Chiral Cyclophane Isoplagiochin D through Atropo-diastereoselective Heck Coupling

(2018) Daniel Meidlinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Ni–Al Bimetallic Catalyzed exo-Selective C–H Cyclization of Imidazoles with Alkenes

(2018) Yin-Xia Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Enantioselective Pyridone C–H Functionalizations Enabled by a Bulky N-Heterocyclic Carbene Ligand

(2018) Johannes Diesel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

(2018) Tyler G. Saint-Denis et al.   SCIENCE

Tailored trisubstituted chiral CpxRhIII catalysts for kinetic resolutions of phosphinic amides

(2018) Y. Sun et al.   Chemical Science

Synthesis of Axially Chiral C–N Scaffolds via Asymmetric Coupling with Enantiopure Sulfinyl Iodanes

(2018) James Rae et al.   ACS Catalysis

Catalyst-Controlled Stereoselective Synthesis of Atropisomers

(2018) Bouthayna Zilate et al.   ACS Catalysis

Access to P - and Axially Chiral Biaryl Phosphine Oxides by Enantioselective Cpx IrIII -Catalyzed C−H Arylations

(2018) Yun-Suk Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality

(2018) José A. Carmona et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity

(2018) Anthony J. Metrano et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Synthesis of Chiral-at-Sulfur 1,2-Benzothiazines by Cpx RhIII -Catalyzed C−H Functionalization of Sulfoximines

(2018) Yang Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles

(2018) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-Catalyzed Enantioselective Coupling of Indoles and 7-Azabenzonorbornadienes by C−H Activation/Desymmetrization

(2018) Xifa Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Ir-Catalyzed Enantioselective, Intramolecular Silylation of Methyl C–H Bonds

(2017) Bo Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic synthesis of axially chiral atropisomers

(2017) P. Renzi   ORGANIC & BIOMOLECULAR CHEMISTRY

Transition-Metal-Catalyzed C–H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds

(2016) Joshua R. Hummel et al.   CHEMICAL REVIEWS

Branch Selective Murai-type Alkene Hydroarylation Reactions

(2016) Giacomo E. M. Crisenza et al.   CHEMISTRY LETTERS

Synthesis of IAN-type N,N-Ligands via Dynamic Kinetic Asymmetric Buchwald–Hartwig Amination

(2016) Pedro Ramírez-López et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis Powered by Chiral Cyclopentadienyl Ligands

(2016) Christopher G. Newton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Application of Chiral Spiro Cp Ligands in Rhodium-Catalyzed Asymmetric Oxidative Coupling of Biaryl Compounds with Alkenes

(2016) Jun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

(2016) Pankaj Jain et al.   Nature Chemistry

Iridium-Catalyzed Diastereo-, Enantio-, and Regioselective Allylic Alkylation with Prochiral Enolates

(2016) J. Caleb Hethcox et al.   ACS Catalysis

Rh(III)-Catalyzed Aryl and Alkenyl C–H Bond Addition to Diverse Nitroalkenes

(2016) Tyler J. Potter et al.   ACS Catalysis

Substrate Activation Strategies in Rhodium(III)-Catalyzed Selective Functionalization of Arenes

(2015) Guoyong Song et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chiral Cyclopentadienyls: Enabling Ligands for Asymmetric Rh(III)-Catalyzed C–H Functionalizations

(2015) Baihua Ye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed CH Functionalization and Spiroannulation

(2015) Suresh Reddy Chidipudi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy

(2015) Jia Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic asymmetric desymmetrization of N-arylmaleimides: efficient construction of both atom chirality and axial chirality

(2015) Jianlin Zhang et al.   CHEMICAL COMMUNICATIONS

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

(2015) J. Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Palladium catalyzed asymmetric Suzuki–Miyaura coupling reactions to axially chiral biaryl compounds: Chiral ligands and recent advances

(2015) Dao Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction

(2015) Jun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed norbornene-mediated C–H functionalization of arenes

(2015) Juntao Ye et al.   Nature Chemistry

Organocatalytic Atroposelective Formal Diels–Alder Desymmetrization of N-Arylmaleimides

(2015) Florine Eudier et al.   ORGANIC LETTERS

Pd(II)-Catalyzed P(O)R1R2-Directed Asymmetric C–H Activation and Dynamic Kinetic Resolution for the Synthesis of Chiral Biaryl Phosphates

(2015) Yan-Na Ma et al.   ORGANIC LETTERS

Construction of Axial Chirality by Rhodium-Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes

(2014) Jun Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Isoindolones by Chiral Cyclopentadienyl-Rhodium(III)-Catalyzed CH Functionalizations

(2014) Baihua Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Axially Chiral Biaryls through Sulfoxide-Directed Asymmetric Mild CH Activation and Dynamic Kinetic Resolution

(2014) Chinmoy Kumar Hazra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective C–H Bond Addition of Pyridines to Alkenes Catalyzed by Chiral Half-Sandwich Rare-Earth Complexes

(2014) Guoyong Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N-Arylmaleimides via Vinylogous Michael Addition

(2014) Nicola Di Iorio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atropodiastereoselective CH Olefination of Biphenylp-Tolyl Sulfoxides with Acrylates

(2013) Thomas Wesch et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Cp-Rhodium(III)-Catalyzed Asymmetric Hydroarylations of 1,1-Disubstituted Alkenes

(2013) Baihua Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric C(sp2)H Activation

(2013) Joanna Wencel-Delord et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Tunable Class of Chiral Cp Ligands for Enantioselective Rhodium(III)-Catalyzed C–H Allylations of Benzamides

(2013) Baihua Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aromatic C–H coupling with hindered arylboronic acids by Pd/Fe dual catalysts

(2013) Kazuya Yamaguchi et al.   Chemical Science

Recent Advances in Iridium-Catalyzed Alkylation of C–H and N–H Bonds

(2013) Shiguang Pan et al.   ACS Catalysis

Recent development of direct asymmetric functionalization of inert C–H bonds

(2013) Chao Zheng et al.   RSC Advances

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization

(2012) B. Ye et al.   SCIENCE

Hindered biaryls by C–H coupling: bisoxazoline-Pd catalysis leading to enantioselective C–H coupling

(2012) Kazuya Yamaguchi et al.   Chemical Science

Pd-catalyzed oxidative coupling with organometallic reagents via C–H activation

(2010) Chang-Liang Sun et al.   CHEMICAL COMMUNICATIONS

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PdII-Catalyzed Enantioselective Activation of C(sp2)H and C(sp3)H Bonds Using Monoprotected Amino Acids as Chiral Ligands

(2008) Bing-Feng Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION