Cerebrovascular insulin receptors are defective in Alzheimer’s disease

Diabetes: Risk Factor and Translational Therapeutic Implications for Alzheimer’s Disease

(2022) Jeffrey Cummings et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

(2022) Andrew C. Yang et al.   NATURE

Increased β‐site APP cleaving enzyme 1‐mediated insulin receptor cleavage in type 2 diabetes mellitus with cognitive impairment

(2021) Hong Bao et al.   Alzheimers & Dementia

The discovery of insulin revisited: lessons for the modern era

(2021) Gary F. Lewis et al.   JOURNAL OF CLINICAL INVESTIGATION

A historical perspective on the interactions of insulin at the blood‐brain barrier

(2021) Elizabeth M. Rhea et al.   JOURNAL OF NEUROENDOCRINOLOGY

Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders

(2021) Christian Hölscher   BRITISH JOURNAL OF PHARMACOLOGY

A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s Disease

(2021) Michael Rosenbloom et al.   DRUGS & AGING

Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin & acute exercise

(2021) Kathryn L. Gwizdala et al.   METABOLIC BRAIN DISEASE

Diabetes mellitus: 100 years since the discovery of insulin

(2021) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brain insulin signaling and cerebrovascular disease in human postmortem brain

(2021) Zoe Arvanitakis et al.   Acta Neuropathologica Communications

The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage

(2021) Bénédicte Gaborit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Brain mural cell loss in the parietal cortex in Alzheimer’s disease correlates with cognitive decline and TDP‐43 pathology

(2020) P. Bourassa et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Role of Caveolin-1 in Diabetes and Its Complications

(2020) Dania Haddad et al.   Oxidative Medicine and Cellular Longevity

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

(2020) Wandong Zhang et al.   Fluids and Barriers of the CNS

Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats

(2020) Hilaree N. Frazier et al.   AGING CELL

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

(2020) Lisa S. Robison et al.   Journal of Neuroinflammation

Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer

(2020) Pierluigi Scalia et al.   Biomolecules

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer’s disease

(2019) Philippe Bourassa et al.   ACTA NEUROPATHOLOGICA

Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3×Tg Mice

(2019) Elena Sanguinetti et al.   Frontiers in Cellular Neuroscience

Diabetes Therapies for Dementia

(2019) Chris Moran et al.   Current Neurology and Neuroscience Reports

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

(2019) Chaitanya Chakravarthi Gali et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

(2019) Elizabeth M. Rhea et al.   Frontiers in Neuroscience

Spatial dynamics of the insulin receptor in living neurons

(2019) Matthias Gralle et al.   JOURNAL OF NEUROCHEMISTRY

Insulin transport into the brain

(2018) Sarah M. Gray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

(2018) Maria Hersom et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

(2018) Yong Shen et al.   BIOLOGICAL PSYCHIATRY

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin exits skeletal muscle capillaries by fluid-phase transport

(2018) Ian M. Williams et al.   JOURNAL OF CLINICAL INVESTIGATION

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

(2018) Zhenlong Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

(2018) Paul J. Meakin et al.   Nature Communications

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

(2018) Liqun He et al.   Scientific Data

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study

(2018) Babak Hooshmand et al.   AMERICAN JOURNAL OF MEDICINE

Insulin Receptor Isoforms in Cancer

(2018) Veronica Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease

(2017) Cyntia Tremblay et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene

(2017) Marie-Thérèse Traversy et al.   PSYCHONEUROENDOCRINOLOGY

The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications

(2017) O. Escribano et al.   Journal of Diabetes Research

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling

(2016) Tomoyuki Yuasa et al.   DIABETOLOGIA

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice

(2016) Molly Stanley et al.   JOURNAL OF NEUROSCIENCE

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease

(2016) Milene Vandal et al.   NEUROBIOLOGY OF AGING

Diabetes and Alzheimer’s disease crosstalk

(2016) David Baglietto-Vargas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

(2015) Kavi Devraj et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

(2015) Mychael V. Lourenco et al.   PROGRESS IN NEUROBIOLOGY

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

(2015) Claire J. Garwood et al.   Molecular Brain

Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery

(2015) Vinko Besic et al.   PLoS One

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

(2013) Anita Stargardt et al.   AGING CELL

Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors

(2013) Hamza Chettouh et al.   CANCER RESEARCH

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

(2013) Dorota Kaminska et al.   DIABETOLOGIA

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease

(2013) Anna M. Barron et al.   PLoS One

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current

(2011) Zhe Jin et al.   PLoS One

 -Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

(2009) O. Escribano et al.   DIABETES

IGF-IR in neuroprotection and brain tumors

(2009) Elisa Gualco   Frontiers in Bioscience-Landmark

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

(2008) Akihiko Urayama et al.   ENDOCRINOLOGY

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY