Article
Endocrinology & Metabolism
Haiyan Cheng, Zhou Zhang, Bing Zhang, Wen Zhang, Jin Wang, Wenyu Ni, Yingwen Miao, Jiani Liu, Yan Bi
Summary: This study demonstrated that liraglutide improved impaired brain activation and cognitive domains in patients with type 2 diabetes, while dapagliflozin and acarbose did not show the same effect.
Review
Biochemistry & Molecular Biology
Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: This article provides an overview of the effect of intranasal insulin administration on memory and its underlying mechanism. It highlights the molecular link between hippocampal insulin resistance and AD and provides a theoretical basis for finding new therapeutic targets for AD in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Caleigh A. Findley, Samuel A. McFadden, MaKayla F. Cox, Lindsey N. Sime, Mackenzie R. Peck, Kathleen Quinn, Andrzej Bartke, Kevin N. Hascup, Erin R. Hascup
Summary: This study investigates the relationship between Alzheimer's disease and metabolic dysfunction, and finds that modulation of glutamatergic activity can improve glucose metabolism and spatial cognition, providing a new therapeutic approach for cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Rebecca M. C. Spencer, Tracy Riggins
Summary: Nap transition is a universal process in human development and understanding it is crucial for maximizing early learning and cognitive outcomes. This study proposes a new hypothesis on the cognitive, physiological, and neural changes that accompany nap transitions, providing new insights into a key window of change in development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Bethany E. Frost, Sean K. Martin, Matheus Cafalchio, Md Nurul Islam, John P. Aggleton, Shane M. O'Mara
Summary: Lesions affecting the anterior thalamic nuclei may be responsible for diencephalic amnesia, similar to how hippocampal lesions cause temporal lobe amnesia. The core element of diencephalic amnesia seems to be the loss of information in hippocampal output regions following anterior thalamic pathology, possibly due to the direct connections between the two areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Carrie L. Branch, Georgy A. Semenov, Dominique N. Wagner, Benjamin R. Sonnenberg, Angela M. Pitera, Eli S. Bridge, Scott A. Taylor, Vladimir V. Pravosudov
Summary: This study investigates the genetic basis of individual variation in spatial cognition in non-migratory food-caching birds and identifies candidate genes associated with this cognitive ability. These findings provide a critical link connecting individual variation in spatial cognition with natural selection.
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alex P. Vaz, John H. Wittig Jr, Sara K. Inati, Kareem A. Zaghloul
Summary: The study investigates the spiking sequences in the human cortex and finds an average backbone sequence, which is associated with cognitive function.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Jamie Snytte, Can Fenerci, Sricharana Rajagopal, Camille Beaudoin, Kiera Hooper, Signy Sheldon, Rosanna K. Olsen, M. Natasha Rajah
Summary: This study investigated how medial temporal lobe (MTL) structure mediates age-related differences in performance on spatial and temporal context memory tasks in healthy adults. The results revealed associations between volume of different MTL regions and memory task performance, with the posterior hippocampus volume fully mediating the relationship between age and spatial context memory performance.
Article
Psychology, Experimental
Xing Xing, Jeffrey A. Saunders
Summary: This study tested whether connections between non-spatial properties can distort judgments about spatial distance. The results showed that similar houses were drawn closer on reconstructed maps, and pairwise distance judgments were smaller for similar houses. These findings support theories that space is represented with other properties, suggesting that the mechanism for encoding space in the hippocampal-entorhinal system has a broader function.
Article
Biochemistry & Molecular Biology
Saltuk Bugra Baltaci, Omer Unal, Elif Gulbahce-Mutlu, Haluk Gumus, Suray Pehlivanoglu, Ahmet Yardimci, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Summary: Our study found that zinc supplementation can improve memory deficits in icv-STZ induced sAD rats, restoring the decline in key molecular targets of synaptic plasticity and insulin signaling.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Emily J. Camm, Christine M. Cross, Andrew D. Kane, Jane L. Tarry-Adkins, Susan E. Ozanne, Dino A. Giussani
Summary: Chronic fetal hypoxia during pregnancy can lead to long-term structural and functional impairments in the adult offspring's brain, particularly affecting neuronal number, vascular and synaptic density in the hippocampus, and memory function. Maternal supplementation with vitamin C during hypoxic pregnancy can protect against oxidative stress in the placenta and prevent adverse effects on hippocampal atrophy and memory loss in the adult offspring, indicating a potential therapeutic strategy.
Article
Neurosciences
Alexandra Badea, Didong Li, Andrei R. R. Niculescu, Robert J. J. Anderson, Jacques A. A. Stout, Christina L. L. Williams, Carol A. A. Colton, Nobuyo Maeda, David B. B. Dunson
Summary: Spatial navigation and orientation are promising markers for early cognitive changes in Alzheimer's disease, and different APOE gene alleles are associated with varying degrees of risk. A new metric, the absolute winding number, accurately assesses differences in spatial search strategies. This research provides insights into the mechanisms and diagnostic methods for Alzheimer's disease, and highlights the role of brain circuits and sex differences in spatial memory and navigation strategies.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Suelen Santos Alves, Rui Milton Patricio da Silva Junior, Polianna Delfino-Pereira, Marilia Gabriella Alves Goulart Pereira, Israel Vasconcelos, Hanna Schwaemmle, Rodrigo Focosi Mazzei, Maiko Luiz Carlos, Enilza Maria Espreafico, Antonio Claudio Tedesco, Adriano Sebollela, Sebastiao Sousa Almeida, Jose Antonio Cortes de Oliveira, Norberto Garcia-Cairasco
Summary: This study explores the behavioral and molecular alterations related to Alzheimer's disease in a genetic model of epilepsy. The findings indicate a partial AD-like phenotype, characterized by altered insulin signaling, in the epilepsy model. The study contributes to the understanding of the connection between epilepsy and AD, highlighting potential therapeutic targets.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xin Du, Yang Zhang, Qiuyue Zhao, Wen Qin, Guangyang Ma, Jilian Fu, Quan Zhang
Summary: This study found that the INSR (rs8101064) genetic variant has an impact on the hippocampal volume in Chinese patients with type 2 diabetes, with T allele carriers exhibiting smaller bilateral hippocampal volumes. The left hippocampal volume was shown to mediate the effect of the INSR (rs8101064) genetic variant on episodic memory in Chinese patients with type 2 diabetes, providing insight into the biological pathway through which this genetic variant affects memory in diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Geriatrics & Gerontology
Hilaree N. Frazier, Adam O. Ghoweri, Emily Sudkamp, Eleanor S. Johnson, Katie L. Anderson, Grant Fox, Keomany Vatthanaphone, Mengfan Xia, Ruei-Lung Lin, Kendra E. Hargis-Staggs, Nada M. Porter, James R. Pauly, Eric M. Blalock, Olivier Thibault
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Neurosciences
Hilaree N. Frazier, Adam O. Ghoweri, Katie L. Anderson, Ruei-Lung Lin, Gabriel J. Popa, Michael D. Mendenhall, Lawrence P. Reagan, Rolf J. Craven, Olivier Thibault
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Adam O. Ghoweri, Peter Gagolewicz, Hilaree N. Frazier, John C. Gant, R. David Andrew, Brian M. Bennett, Olivier Thibault
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Oncology
Yang Zhang, Bingwei Xu, Junfeng Shi, Jieming Li, Xinlan Lu, Li Xu, Helen Yang, Nevean Hamad, Chi Wang, Dana Napier, Shuixiang He, Chunming Liu, Zeyi Liu, Hai Qian, Li Chen, Xiaowei Wei, Xucai Zheng, Jian-An Huang, Olivier Thibault, Rolf Craven, Dongping Wei, Yueyin Pan, Binhua P. Zhou, Yadi Wu, Xiuwei H. Yang
Article
Neurosciences
Adam O. Ghoweri, Lara Ouillette, Hilaree N. Frazier, Katie L. Anderson, Ruei-Lung Lin, John C. Gant, Rachel Parent, Shannon Moore, Geoffrey G. Murphy, Olivier Thibaulta
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Cell Biology
Ruei-Lung Lin, Hilaree N. Frazier, Katie L. Anderson, Sami L. Case, Adam O. Ghoweri, Olivier Thibault
Summary: Neuronal hippocampal Ca2+ dysregulation is a critical factor in cognitive decline in brain aging and Alzheimer's disease, potentially influencing communication and excitability between neurons. This study investigated Ca2+ network dysregulation in the primary somatosensory cortex of young and aged rats, finding increased activity and connectivity in aged animals along with decreased ambulatory speed. Intranasal insulin increased network synchronicity and ambulatory speed. Importantly, the delivery of a Ca2+ channel modifier replicated some of the changes seen in the older animals. These findings suggest that Ca2+ dysregulation may extend to other areas of the brain and impact locomotor stability and motivation to ambulate.
Review
Biochemistry & Molecular Biology
Sami L. Case, Hilaree N. Frazier, Katie L. Anderson, Ruei-Lung Lin, Olivier Thibault
Summary: Insulin resistance in the brain is associated with cognitive decline and reduced brain activity, but the mechanisms underlying this resistance and its effects on non-cognitive brain regions are unclear. Falls are a common cause of injury in older people, but there is limited research on age-related changes and treatments. Insulin receptor sensitivity may be preserved in the aging brain, and administration of insulin can alter neuronal communication, cerebral blood flow, and motivation to walk, suggesting its potential as a clinical management strategy in older individuals.
Article
Cell Biology
Sami L. Case, Ruei-Lung Lin, Olivier Thibault
Summary: Over the past 30 years, the calcium (Ca2+) hypothesis of brain aging has provided clear evidence that hippocampal neuronal Ca2+ dysregulation is a key biomarker of aging. Investigations in the awake animal are needed to test the generalizability of the Ca2+ hypothesis of brain aging.