Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease

Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimer’s Disease Model

(2022) Alejandro Lillo et al.   Biomedicines

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer’s Disease

(2022) Stefania Merighi et al.   MOLECULES

Could drugs prevent Alzheimer’s? These trials aim to find out

(2022) Alison Abbott   NATURE

Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer’s Disease Dementia

(2021) Andrée-Ann Baril et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

(2021) Rumana Akhter et al.   MOLECULAR IMMUNOLOGY

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

(2021) Leslie A. Sandusky-Beltran et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Role of extracellular vesicles in neurodegenerative diseases

(2021) Yun Xiao et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease

(2021) Lauren H. Fairley et al.   Frontiers in Immunology

Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer’s Disease

(2021) Casimir Bamberger et al.   JOURNAL OF PROTEOME RESEARCH

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

(2021) Sheng Yang et al.   NEUROBIOLOGY OF DISEASE

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

(2021) Chao Wang et al.   NEURON

STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection

(2021) Marco Tulio R. Gomes et al.   PLoS Pathogens

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

(2021) Natalia M. Lyra e Silva et al.   Translational Psychiatry

SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

(2021) Grazia Ilaria Caruso et al.   Biomedicines

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

(2021) Ana Belen Lopez‐Rodriguez et al.   Alzheimers & Dementia

Amyloid-β: A double agent in Alzheimer's disease?

(2021) Hao Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

(2021) Mariana Van Zeller et al.   JOURNAL OF ALZHEIMERS DISEASE

A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

(2021) Hina Shaheen et al.   Frontiers in Computational Neuroscience

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

(2021) Shanya Jiang et al.   Cell Reports

Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

(2021) Chinmaya Panda et al.   Cells

Brain Exosomes: Friend or Foe in Alzheimer’s Disease?

(2021) Sharanjot Kaur et al.   MOLECULAR NEUROBIOLOGY

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes

(2021) Matthew J. Moulton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

(2021) Faten A. Sayed et al.   Science Translational Medicine

Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

(2021) Meihua Jin et al.   Nature Communications

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

(2021) Anusha Jayaraman et al.   Acta Neuropathologica Communications

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

(2020) Masaru Tanaka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology

(2020) Mirjana Babić Leko et al.   JOURNAL OF ALZHEIMERS DISEASE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

p38gamma MAPK is essential for aerobic glycolysis and pancreatic tumorigenesis

(2020) Fang Wang et al.   CANCER RESEARCH

TREM2 ectodomain and its soluble form in Alzheimer’s disease

(2020) Jiaolong Yang et al.   Journal of Neuroinflammation

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease

(2020) Stefan M. Ivanov et al.   Scientific Reports

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

(2020) Dongdong Jiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

In vivo evidence of exosome-mediated Aβ neurotoxicity

(2020) Ahmed Elsherbini et al.   Acta Neuropathologica Communications

Role of Mitochondrial Dysfunction in the Pathology of Amyloid-β

(2020) Zhenting Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

(2020) Yang Liu et al.   NEUROSCIENCE LETTERS

Microglia and lipids: how metabolism controls brain innate immunity

(2020) Bruno Chausse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microglial Immunometabolism in Alzheimer’s Disease

(2020) Daniel C. Shippy et al.   Frontiers in Cellular Neuroscience

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

(2020) Albin John et al.   AGEING RESEARCH REVIEWS

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

(2019) Allison McIntosh et al.   BRAIN PATHOLOGY

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

(2019) Luxi Wang et al.   Molecular Neurodegeneration

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

(2019) Silvia Marinelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

The complexity of tau in Alzheimer’s disease

(2019) Nima N. Naseri et al.   NEUROSCIENCE LETTERS

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid

(2019) Longfei Jia et al.   Alzheimers & Dementia

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

(2019) Yang Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

(2019) Yuqin Men et al.   Nature Communications

Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture

(2019) Zhenyu Yin et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

(2018) R. Holland et al.   BRAIN BEHAVIOR AND IMMUNITY

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

(2018) Richard G. Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

(2018) Long Wu et al.   JOURNAL OF NEUROSCIENCE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

(2018) Rosa C. Paolicelli et al.   NEUROSCIENCE

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Lysine Deacetylases and Regulated Glycolysis in Macrophages

(2018) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway

(2018) Juan Ramón Perea et al.   EXPERIMENTAL NEUROLOGY

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

(2018) Ana Rubio-Araiz et al.   Journal of Neuroinflammation

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Microglia metabolism in health and disease

(2018) Katharina Borst et al.   NEUROCHEMISTRY INTERNATIONAL

L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease

(2018) Baruh Polis et al.   Neurotherapeutics

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

(2017) Jing Zhao et al.   HUMAN MOLECULAR GENETICS

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of the CX3CR1-V249I Variant with Neurofibrillary Pathology Progression in Late-Onset Alzheimer’s Disease

(2017) Alan López-López et al.   MOLECULAR NEUROBIOLOGY

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

(2017) R. W. Hallowell et al.   Nature Communications

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

(2016) Nora Hagemeyer et al.   EMBO JOURNAL

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

(2015) J. B. Hunt et al.   JOURNAL OF NEUROSCIENCE

Exploring the association between interleukin-1β and its interacting proteins in Alzheimer’s disease

(2015) LUSHUANG XIE et al.   Molecular Medicine Reports

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Blockage of CR1 prevents activation of rodent microglia

(2013) Helen Crehan et al.   NEUROBIOLOGY OF DISEASE

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Antioxidant role of amyloid β protein in cell-free and biological systems: implication for the pathogenesis of Alzheimerdisease

(2012) Maitrayee Sinha et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional aerobic glycolysis in the human brain

(2010) S. Neil Vaishnavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia

(2009) Sébastien Tilleux et al.   NEUROCHEMISTRY INTERNATIONAL

A peptide containing residues 26–44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator

(2008) A. Atlante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity

(2008) Jianfeng Liang et al.   BRAIN RESEARCH

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA