Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
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Title
Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
Authors
Keywords
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Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-06-22
DOI
10.1038/s41598-020-67119-x
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Note: Only part of the references are listed.- Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry
- (2019) Gabriela Prus et al. TRENDS IN BIOCHEMICAL SCIENCES
- Bridging solvent molecules mediate RNase A – Ligand binding
- (2019) Stefan M. Ivanov et al. PLoS One
- Research and development of anti-Alzheimer’s disease drugs: an update from the perspective of technology flows
- (2018) Kunmeng Liu et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- FoldX as Protein Engineering Tool: Better Than Random Based Approaches?
- (2018) Oliver Buß et al. Computational and Structural Biotechnology Journal
- Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration
- (2018) Jian-Zhi Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- The amyloid hypothesis on trial
- (2018) Simon Makin NATURE
- Energetic Fingerprinting of Ligand Binding to Paralogous Proteins: The Case of the Apoptotic Pathway
- (2018) Stefan M. Ivanov et al. Journal of Chemical Information and Modeling
- Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015
- (2017) Dev Mehta et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome
- (2017) Harutsugu Tatebe et al. Molecular Neurodegeneration
- Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease
- (2017) Ana L. Santos et al. Oxidative Medicine and Cellular Longevity
- A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
- (2017) Miranda E. Orr et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
- (2017) Susmitha Ambadipudi et al. Nature Communications
- Multiplexed gene control reveals rapid mRNA turnover
- (2017) Antoine Baudrimont et al. Science Advances
- Differential Incorporation of Tau Isoforms in Alzheimer's Disease
- (2017) Marisol Espinoza et al. JOURNAL OF ALZHEIMERS DISEASE
- Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold
- (2017) Stefan M. Ivanov et al. PLoS One
- Liquid–liquid phase separation in cellular signaling systems
- (2016) P Andrew Chong et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Neurofibrillary tangles in Alzheimer′s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics
- (2016) StefanJ Kempf et al. Neural Regeneration Research
- Energetics and Dynamics Across the Bcl-2-Regulated Apoptotic Pathway Reveal Distinct Evolutionary Determinants of Specificity and Affinity
- (2016) Stefan M. Ivanov et al. STRUCTURE
- Folding of the Tau Protein on Microtubules
- (2015) Harindranath Kadavath et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- What lessons can be learned from failed Alzheimer’s disease trials?
- (2015) Jeremy Toyn Expert Review of Clinical Pharmacology
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- The role of neuronal versus astrocyte-derived heparan sulfate proteoglycans in brain development and injury: Table 1
- (2014) Isabella Farhy Tselnicker et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The function of spermine
- (2014) Anthony E. Pegg IUBMB LIFE
- Endogenous polyamine function—the RNA perspective
- (2014) Helen L. Lightfoot et al. NUCLEIC ACIDS RESEARCH
- Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: Beyond cognition
- (2013) Joanne M. Hamilton et al. Alzheimers & Dementia
- What is next generation sequencing?
- (2013) Sam Behjati et al. Archives of Disease in Childhood-Education and Practice Edition
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- Forcefield_PTM: Ab Initio Charge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational Modifications
- (2013) George A. Khoury et al. Journal of Chemical Theory and Computation
- Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells
- (2013) S. Mandal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem
- (2013) Kerry L. Gendreau et al. Frontiers in Neurology
- Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
- (2012) David J. Irwin et al. BRAIN
- MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
- (2012) Bill R. Miller et al. Journal of Chemical Theory and Computation
- Phase transitions in the assembly of multivalent signalling proteins
- (2012) Pilong Li et al. NATURE
- Altered regulation of tau phosphorylation in a mouse model of down syndrome aging
- (2011) Olivia Sheppard et al. NEUROBIOLOGY OF AGING
- Heparan Sulfate Proteoglycans
- (2011) S. Sarrazin et al. Cold Spring Harbor Perspectives in Biology
- The acetylation of tau inhibits its function and promotes pathological tau aggregation
- (2011) Todd J. Cohen et al. Nature Communications
- The Role of Tau in Alzheimer's Disease and Related Disorders
- (2010) Rodrigo Medeiros et al. CNS Neuroscience & Therapeutics
- Tau in Alzheimer Disease and Related Tauopathies
- (2010) K. Iqbal et al. Current Alzheimer Research
- Calculation of the free energy of association for protein complexes
- (2010) Nancy Horton et al. PROTEIN SCIENCE
- Modulation of cellular function by polyamines
- (2009) Kazuei Igarashi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The role of tau in neurodegeneration
- (2009) Tania F Gendron et al. Molecular Neurodegeneration
- Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
- (2008) C.-X. Gong et al. CURRENT MEDICINAL CHEMISTRY
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