mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice

(2016) Michael Shum et al.   DIABETOLOGIA

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Tsc1 is a Critical Regulator of Macrophage Survival and Function

(2015) Chunmin Fang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

(2015) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

(2015) Mika Yasui et al.   PLoS One

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype

(2014) Lucia Lisi et al.   Journal of Neuroinflammation

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

(2014) Maximilian Kleinert et al.   Molecular Metabolism

Effect of nematode Trichinella infection on glucose tolerance and status of macrophage in obese mice

(2013) Hideyuki Okada et al.   ENDOCRINE JOURNAL

Rapamycin unbalances the polarization of human macrophages to M1

(2013) Alessia Mercalli et al.   IMMUNOLOGY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function

(2012) B. Kellersch et al.   BLOOD

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+Cell Depletion

(2012) Katherine A. Smith et al.   INFECTION AND IMMUNITY

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

(2012) Malgorzata Urbanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production

(2012) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice

(2011) Jiansheng Huang et al.   FASEB JOURNAL

Application of carbon monoxide diffusing capacity in the mouse lung

(2011) Jon Fallica et al.   JOURNAL OF APPLIED PHYSIOLOGY

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens

(2011) Judith E. Allen et al.   PLoS Pathogens

Alternatively Activated Macrophages as Cause or Effect in Airway Disease

(2010) Derek E. Byers et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

(2010) Jessica M. Ellis et al.   Cell Metabolism

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Comprehensive analysis of TLR4-induced transcriptional responses in interleukin 4-primed mouse macrophages

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

(2009) S. Fujisaka et al.   DIABETES

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Alternatively activated macrophages in infection and autoimmunity

(2009) DeLisa Fairweather et al.   JOURNAL OF AUTOIMMUNITY

Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

(2009) Greg M. Delgoffe et al.   MOLECULAR IMMUNOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians

(2008) E. Ortega Martinez de Victoria et al.   DIABETES

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Dynamics of lung macrophage activation in response to helminth infection

(2008) Mark C. Siracusa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling