Role of Mitochondrial Dysfunction in the Pathology of Amyloid-β

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease

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AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics

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In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

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Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction

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Autophagy modulates Aβ accumulation and formation of aggregates in yeast

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Comparative Effects of Alpha- and Gamma-Tocopherol on Mitochondrial Functions in Alzheimer’s Disease In Vitro Model

(2020) Aslina Pahrudin Arrozi et al.   Scientific Reports

Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

(2020) Jessica D. Panes et al.   Frontiers in Pharmacology

Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM

(2020) Zhe Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer’s disease

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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

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Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

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Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

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Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives

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The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

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Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

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Mechanisms and context underlying the role of autophagy in cancer metastasis

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THANATOS: an integrative data resource of proteins and post-translational modifications in the regulation of autophagy

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Poly-ubiquitin profile in Alzheimer disease brain

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Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy

(2018) Shu-Hui Xin et al.   NEUROTOXICITY RESEARCH

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

(2018) Varda Shoshan-Barmatz et al.   PHARMACOLOGICAL RESEARCH

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells

(2018) Alexa Parousis et al.   Autophagy

Imaging the evolution and pathophysiology of Alzheimer disease

(2018) William Jagust   NATURE REVIEWS NEUROSCIENCE

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

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The KATP Channel Activator Diazoxide Ameliorates Amyloid-β and Tau Pathologies and Improves Memory in the 3xTgAD Mouse Model of Alzheimer's Disease

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Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine

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MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff

(2017) Rong Yu et al.   Scientific Reports

Mitochondria-targeted antioxidant mitotempo protects mitochondrial function against amyloid beta toxicity in primary cultured mouse neurons

(2016) Hongtao Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk

(2015) Katalin Volgyi et al.   Current Alzheimer Research

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

(2015) Sónia C. Correia et al.   DNA AND CELL BIOLOGY

Critical analysis of Alzheimer rsquo s amyloid-beta nbsp toxicity to mitochondria

(2015) Yury G. Kaminsky   Frontiers in Bioscience-Landmark

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines

(2015) Gary E. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

(2015) Aya Zakaria et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Inhibition of Akt Phosphorylation Diminishes Mitochondrial Biogenesis Regulators, Tricarboxylic Acid Cycle Activity and Exacerbates Recognition Memory Deficit in Rat Model of Alzheimer’s Disease

(2014) Fatemeh Shaerzadeh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Two β-strands of RAGE participate in the recognition and transport of amyloid-β peptide across the blood brain barrier

(2013) Sun-Jick Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Monitoring of Neuronal Loss in the Hippocampus of Aβ-Injected Rat: Autophagy, Mitophagy, and Mitochondrial Biogenesis Stand Against Apoptosis

(2013) Fatemeh Shaerzadeh et al.   NEUROMOLECULAR MEDICINE

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

(2012) Sang-Sun Yoon et al.   Biomolecules & Therapeutics

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

(2012) P. Mao et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: 13C NMR and magnetic resonance imaging studies in AD models

(2012) Norah Algarzae et al.   NEUROSCIENCE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular and metabolic dysfunction in Alzheimer's disease: a review

(2011) Ian V J Murray et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex

(2011) Qingli Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial structural and functional dynamics in Huntington's disease

(2009) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Mitochondria and Alzheimer’s disease: amyloid-β peptide uptake and degradation by the presequence protease, hPreP

(2009) Nyosha Alikhani et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE