Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases

Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

(2022) Hüseyin Gümüş et al.   JOURNAL OF MEDICAL VIROLOGY

High expression of nuclear NRF2 combined with NFE2L2 alterations predicts poor prognosis in esophageal squamous cell carcinoma patients

(2022) Xingran Jiang et al.   MODERN PATHOLOGY

Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial

(2022) Sarfraz Ahmed et al.   Oxidative Medicine and Cellular Longevity

Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial

(2022) Fatemeh Pourhabibi‐Zarandi et al.   PHYTOTHERAPY RESEARCH

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

(2022) Sarmistha Saha et al.   Frontiers in Cellular Neuroscience

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

(2022) Anu Chacko et al.   Scientific Reports

Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress

(2022) Yunjia Li et al.   Frontiers in Pharmacology

Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota

(2022) Qiao Xiang et al.   Foods

Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals

(2022) Esam O. Kamel et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling

(2022) JianYu Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H 2 O 2 generation and reductive stress effects of cadmium

(2022) Desirée Bartolini et al.   JOURNAL OF PINEAL RESEARCH

Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease

(2022) Alysa Kasen et al.   NEUROBIOLOGY OF DISEASE

Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment

(2022) Hitesh Kumar et al.   Frontiers in Pharmacology

Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase/protein kinase B pathway: an in vitro and in vivo study

(2022) Zihan Xu et al.   Bioengineered

Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice

(2022) Ji-Xian Song et al.   Bioengineered

Identification and Contribution of Inflammation-Induced Novel MicroRNA in the Pathogenesis of Systemic Lupus Erythematosus

(2022) Ram P. Singh et al.   Frontiers in Immunology

Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling

(2022) Chenxu Ge et al.   Redox Biology

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

(2022) Alvaro A. Ordonez et al.   Communications Biology

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

(2022) Sarah Jacob et al.   Frontiers in Neurology

Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

(2021) Irina Gessl et al.   ANNALS OF THE RHEUMATIC DISEASES

Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies

(2021) Adnan Ayna et al.   CURRENT DRUG METABOLISM

Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets

(2021) Zemin Lin et al.   Science China-Life Sciences

Synthesis of 4-(3-oxo-3-phenylpropyl)morpholin-4-ium chloride analogues and their inhibitory activities of nitric oxide production in lipopolysaccharide-induced BV2 cells

(2021) Sung-Hwa Yoon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluoxetine Can Inhibit SARS-CoV-2 In Vitro

(2021) Arthur Dechaumes et al.   Microorganisms

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro

(2021) Sebastian Schloer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund's adjuvant-induced arthritis in rats

(2021) Roshan Lal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein

(2021) Jessica Gasparello et al.   PHYTOMEDICINE

Catalytic synthesis of PEGylated EGCG conjugates that disaggregate Alzheimer’s tau

(2021) Anton El Khoury et al.   SYNTHESIS-STUTTGART

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

(2021) Melissa Zimniak et al.   Scientific Reports

Flavonoids against the SARS-CoV-2 induced inflammatory storm

(2021) Alena Liskova et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential protective mechanisms of green tea polyphenol EGCG against COVID-19

(2021) Zhichao Zhang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Artemisinin derivative SM934, influences the activation, proliferation, differentiation and antibody-secreting capacity of β-cells in systemic lupus erythematosus mice via inhibition of TLR7/9 signaling pathway

(2021) Yajuan Li et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

(2021) Bram M. ter Ellen et al.   Viruses-Basel

Non-Specific Immunity Associated Gut Microbiome in Aristichthys nobilis under Different Rearing Strategies

(2021) Jianming Yuan et al.   Genes

Mycophenolic Acid Exposure Optimization Based on Vitamin D Status in Children with Systemic Lupus Erythematosus: A Single-Center Retrospective Study

(2021) Qiaofeng Ye et al.   Rheumatology and Therapy

Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial

(2021) Jiachen Gu et al.   Neurology and Therapy

Antioxidant activities of inula viscosa extract and curcumin on U87 cells induced by beta-amyloid

(2021) Ares ALİZADE et al.   Cukurova Medical Journal

Dopamine in Parkinson's disease

(2021) Saad Latif et al.   CLINICA CHIMICA ACTA

Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition

(2021) Maha H. Sharawy et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)

(2021) Nahla Mohammed Abd El-Hameed et al.   LIFE SCIENCES

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms

(2021) Damariz Marín-Palma et al.   MOLECULES

Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro

(2021) Maren Bormann et al.   Viruses-Basel

Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2

(2021) Huiyan Deng et al.   Bioengineered

Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease

(2021) Junhua Xie et al.   Acta Neuropathologica Communications

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

(2020) Shuya Kasai et al.   Biomolecules

γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice

(2020) Sho Kobayashi et al.   AMINO ACIDS

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway

(2020) Xue Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Beyond repression of Nrf2: An update on Keap1

(2020) Aleksandra Kopacz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intestinal bile acids directly modulate the structure and function ofC. difficileTcdB toxin

(2020) John Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimethyl fumarate prevents osteoclastogenesis by decreasing NFATc1 expression, inhibiting of erk and p38 MAPK phosphorylation, and suppressing of HMGB1 release

(2020) Tsuyoshi Nishioku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer’s Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

(2020) Ih-Jen Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review

(2020) Sylvia Maina et al.   MOLECULES

Peripheral inflammation exacerbates α‐synuclein toxicity and neuropathology in Parkinson's models

(2020) P. La Vitola et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model

(2020) Malika Ali et al.   PLoS One

Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer’s models

(2020) Chun-Yan Wang et al.   Redox Biology

Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia

(2020) Chih-Yin Lin et al.   Infection and Drug Resistance

Role of Nrf2 in rheumatoid arthritis

(2020) Swati Chadha et al.   Current Research in Translational Medicine

Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro

(2020) Minsu Jang et al.   Evidence-based Complementary and Alternative Medicine

N-Ethyl-2-Pyrrolidinone-Substituted Flavan-3-Ols with Anti-inflammatory Activity in Lipopolysaccharide-Stimulated Macrophages Are Storage-Related Marker Compounds for Green Tea

(2020) Weidong Dai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle

(2020) Lie Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling

(2020) Chenjia Guo et al.   NEUROBIOLOGY OF AGING

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

(2020) Jonathan Muri et al.   Redox Biology

Naringin in Combination with Isothiocyanates as Liposomal Formulations Potentiates the Anti-inflammatory Activity in Different Acute and Chronic Animal Models of Rheumatoid Arthritis

(2020) Sangeeta Mohanty et al.   ACS Omega

NQO1 promotes an aggressive phenotype in hepatocellular carcinoma via amplifying ERK‐NRF2 signaling

(2020) Yun Yang et al.   CANCER SCIENCE

Efficacy of Sulforaphane in Neurodegenerative Diseases

(2020) Giovanni Schepici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure

(2020) Valeria Sorrenti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease

(2020) Yuwei Yang et al.   TOXICOLOGY

Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2

(2020) Yue Zhu et al.   Frontiers in Plant Science

Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2

(2020) Xia Xiao et al.   Frontiers in Immunology

Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease

(2020) Ji Won Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway

(2020) Koji Ishida et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B

(2019) Zhenxian Zhang et al.   Biomed Research International

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease

(2019) Zein Al-Atrache et al.   BMC NEUROSCIENCE

Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle)

(2019) Ji Yeong Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/ HO ‐1 and AMPK signalling pathways

(2019) Bingyu Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

(2019) Amanda Cano et al.   JOURNAL OF CONTROLLED RELEASE

Singlet oxygen species and systemic lupus erythematosus: a brief review

(2019) Rizwan Ahmad et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis

(2019) Vasilios Tzilas et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress

(2019) Yiru Wang et al.   Aging-US

Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

(2019) Yaoyu Pu et al.   Aging-US

The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital

(2019) L Hamijoyo et al.   LUPUS

Trans-4,4′-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response

(2019) Tian Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

Clinical evaluation of dimethyl fumarate for the treatment of relapsing-remitting multiple sclerosis: efficacy, safety, patient experience and adherence

(2019) Bhavya Narapureddy et al.   Patient Preference and Adherence

Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling

(2019) Jiahe Li et al.   ANESTHESIOLOGY

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

(2019) Hyeon Jeong Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway

(2019) Hossein Hosseini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Caffeic acid inhibits HCV replication via induction of IFNα antiviral response through p62-mediated Keap1/Nrf2 signaling pathway

(2018) Jian Shen et al.   ANTIVIRAL RESEARCH

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice

(2018) Caixia Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

(2018) Yeon-Joo Jung et al.   Biomolecules & Therapeutics

Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy

(2018) Passant E. Moustafa et al.   INFLAMMATION

Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease

(2018) Siyoung Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ 1–42

(2018) Haifeng Zhao et al.   NEUROSCIENCE

Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo

(2018) Jeffrey Boehm et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel insights into the glia limitans of the olfactory nervous system

(2018) Lynn Nazareth et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

(2018) Maria Ruart et al.   JOURNAL OF HEPATOLOGY

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

(2018) Michał Wiciński et al.   Nutrients

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

(2018) Syed Zahid Ali Shah et al.   Frontiers in Molecular Neuroscience

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm inCaenorhabditis elegans

(2017) Taro Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation

(2017) Yuuki Yamaguchi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Parkin loss-of-function pathology: Premature neuronal senescence induced by high levels of reactive oxygen species?

(2017) Lori M. Buhlman   MECHANISMS OF AGEING AND DEVELOPMENT

(−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer’s disease

(2017) Yufang Guo et al.   NEUROREPORT

Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids

(2017) Liangfeng Fu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

(2017) Nishanth E. Sunny et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression

(2017) Jingzhu Zhang et al.   Frontiers in Aging Neuroscience

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity

(2017) Hany M. Abo-Haded et al.   PLoS One

The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review

(2017) C. Gonzalez-Donquiles et al.   PLoS One

Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis

(2017) Urszula Wasik et al.   Scientific Reports

Synthesis and Biological Evaluation of Novel Resveratrol-NSAID Derivatives as Anti-inflammatory Agents

(2016) Wei Peng et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines

(2016) Kyril Turpaev et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oral bioavailability of curcumin: problems and advancements

(2016) Weidong Liu et al.   JOURNAL OF DRUG TARGETING

Nrf2: a modulator of Parkinson’s disease?

(2016) Michael Todorovic et al.   JOURNAL OF NEURAL TRANSMISSION

Fluoxetine protects against methamphetamine-induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats

(2016) Yun Wang et al.   Molecular Medicine Reports

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

(2016) Olga A. Smirnova et al.   Oxidative Medicine and Cellular Longevity

Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway

(2016) Jung-Sheng Yu et al.   PLoS One

Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review

(2016) Celia María Quiñonez-Flores et al.   Biomed Research International

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function

(2016) Mei Zhao et al.   Scientific Reports

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

(2015) Alexander Ivanov et al.   Viruses-Basel

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

(2015) B Liu et al.   Cell Death & Disease

Synthesis and biological evaluation of bile carboxamide derivatives with pro-apoptotic effect on human colon adenocarcinoma cell lines

(2014) Dominique Brossard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer’s Disease-Like Lesions

(2014) Rui Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

Dietary Supplementation with (−)-Epigallocatechin-3-gallate Reduces Inflammatory Response in Adipose Tissue of Non-obese Type 2 Diabetic Goto-Kakizaki (GK) Rats

(2013) Yumiko Uchiyama et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Efficient and Scalable Synthesis of Bardoxolone Methyl (CDDO-methyl Ester)

(2013) Liangfeng Fu et al.   ORGANIC LETTERS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Vitamin D3-Based Hedgehog Pathway Inhibitors That Incorporate an Aromatic A-Ring Isostere

(2013) Albert M. DeBerardinis et al.   ACS Medicinal Chemistry Letters

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents

(2012) Suqing Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers

(2012) Juan Miguel Lopez del Amo et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

(2012) Sandra L. Silva et al.   NEUROPHARMACOLOGY

Simplified Heterocyclic Analogues of Fluoxetine Inhibit Inducible Nitric Oxide Production in Lipopolysaccharide-Induced BV2 Cells

(2011) Ju-Young Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fumaric acid and its esters: An emerging treatment for multiple sclerosis with antioxidative mechanism of action

(2011) R. Gold et al.   CLINICAL IMMUNOLOGY

Promising Pharmacological, Molecular and Cellular Treatments of Autoimmune Hepatitis

(2011) Albert J. Czaja   CURRENT PHARMACEUTICAL DESIGN

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins

(2011) Monica Carvajal-Yepes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Hepatic Nrf2 Activation After Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis

(2010) Kazuhito Kawata et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure–activity relationship

(2010) Umang Singh et al.   FREE RADICAL RESEARCH

Effects of Silibinin, Inhibitor of CYP3A4 and P-Glycoprotein in vitro, on the Pharmacokinetics of Paclitaxel after Oral and Intravenous Administration in Rats

(2010) Chong-Ki Lee et al.   PHARMACOLOGY

Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities

(2009) Ka-Heng Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo

(2009) Li-Fei Hou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY