Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

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Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

(2017) Mitsuru Shinohara et al.   JOURNAL OF LIPID RESEARCH

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

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Oleocanthal ameliorates amyloid-β oligomers’ toxicity on astrocytes and neuronal cells: In vitro studies

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Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

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Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1  and TNF- 

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(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

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Etiology and Pathogenesis of Late-Onset Alzheimer’s Disease

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A study on the association between infectious burden and Alzheimer's disease

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Chlamydia pneumoniae infection of monocytes in vitro stimulates innate and adaptive immune responses relevant to those in Alzheimer’s disease

(2014) Charles Lim et al.   Journal of Neuroinflammation

MAPK–PPARα/γ signal transduction pathways are involved in Chlamydia pneumoniae-induced macrophage-derived foam cell formation

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Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

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A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Chlamydia pneumoniae Infection in Atherosclerotic Lesion Development through Oxidative Stress: A Brief Overview

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

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(2013) L. E. Hebert et al.   NEUROLOGY

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

(2012) Michela Guglielmotto et al.   AGING CELL

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

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(2012) Cherilyn A. Elwell et al.   CELLULAR MICROBIOLOGY

Transcription factor complex AP-1 mediates inflammation initiated byChlamydia pneumoniaeinfection

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Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Membrane Trafficking Pathways in Alzheimer's Disease

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Identification and biology of β-secretase

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Identification and biology of α-secretase

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(2011) Alison Goate et al.   JOURNAL OF NEUROCHEMISTRY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Chlamydia persistence – a tool to dissect chlamydia–host interactions

(2011) R.V. Schoborg   MICROBES AND INFECTION

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain

(2010) Christine J Hammond et al.   BMC NEUROSCIENCE

Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARγ dependent signal transduction pathways

(2010) Wei Liu et al.   MICROBES AND INFECTION

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle

(2010) C.J. Carter   NEUROSCIENCE LETTERS

Alzheimer's Disease

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Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain

(2008) Ute Dreses-Werringloer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E4 enhances attachment of Chlamydophila (Chlamydia) pneumoniae elementary bodies to host cells

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