Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Chloroquine for the 2019 novel coronavirus SARS-CoV-2

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The outbreak of COVID-19

(2020) Yi-Chi Wu et al.   Journal of the Chinese Medical Association

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

Discovery and characterization of tannase genes in plants: roles in hydrolysis of tannins

(2020) Xinlong Dai et al.   NEW PHYTOLOGIST

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

(2020) Zhenming Jin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19

(2020) Moussa Sehailia et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2

(2020) D. S. N. B. K. Prasanth et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors – an in silico docking and molecular dynamics simulation study

(2020) Rajesh Ghosh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

(2020) Markus Hoffmann et al.   NATURE

From flavanols biosynthesis to wine tannins: what place for grape seeds?

(2019) Pauline ROUSSERIE et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Functional demonstration of plant flavonoid carbocations proposed to be involved in the biosynthesis of proanthocyanidins

(2019) Peiqiang Wang et al.   PLANT JOURNAL

Epicatechin’s cardiovascular protective effects are mediated via opioid receptors and nitric oxide

(2018) Kirsty MacRae et al.   EUROPEAN JOURNAL OF NUTRITION

Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men

(2018) Wai Mun Loke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic Characterization of the Anthocyanidin Reductase Pathway Involved in the Biosynthesis of Flavan-3-ols in Elite Shuchazao Tea (Camellia sinensis) Cultivar in the Field

(2017) Lei Zhao et al.   MOLECULES

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular cloning and functional characterization of the anthocyanidin reductase gene from Vitis bellula

(2014) Yue Zhu et al.   PLANTA

Premature and ectopic anthocyanin formation by silencing of anthocyanidin reductase in strawberry (Fragaria × ananassa)

(2013) Thilo C. Fischer et al.   NEW PHYTOLOGIST

Purification and Characterization of a Novel Galloyltransferase Involved in Catechin Galloylation in the Tea Plant (Camellia sinensis)

(2012) Yajun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on δ-opioid receptor stimulation

(2010) Mathivadhani Panneerselvam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antiviral Activity of Proanthocyanidin against Feline Calicivirus Used as a Surrogate for Noroviruses, and Coxsackievirus Used as a Representative Enteric Virus

(2010) ATSUO IWASAWA et al.   BIOCONTROL SCIENCE

New cancer treatment strategy using combination of green tea catechins and anticancer drugs

(2010) Masami Suganuma et al.   CANCER SCIENCE

Survey of Commercially Available Chocolate- and Cocoa-Containing Products in the United States. 2. Comparison of Flavan-3-ol Content with Nonfat Cocoa Solids, Total Polyphenols, and Percent Cacao

(2009) Kenneth B. Miller et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Expression balances of structural genes in shikimate and flavonoid biosynthesis cause a difference in proanthocyanidin accumulation in persimmon (Diospyros kaki Thunb.) fruit

(2009) Takashi Akagi et al.   PLANTA

Catechin, epicatechin, quercetin, rutin and resveratrol in red grape: Content, in vitro antioxidant activity and interactions

(2008) P. Iacopini et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS