Flavonoids against the SARS-CoV-2 induced inflammatory storm

Flavonoids and gut health

(2020) Ruisong Pei et al.   CURRENT OPINION IN BIOTECHNOLOGY

Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells

(2020) Asuman Deveci Ozkan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

(2020) Rasha Al-Rikabi et al.   MOLECULES

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

(2020) Camila R. Ferraz et al.   MOLECULES

Potential Therapeutic Anti-Inflammatory and Immunomodulatory Effects of Dihydroflavones, Flavones, and Flavonols

(2020) Cristina Zaragozá et al.   MOLECULES

Flavonoids as Anticancer Agents

(2020) Dalia M. Kopustinskiene et al.   Nutrients

Dipeptidyl Peptidase-4 Is a Target Protein of Epigallocatechin-3-Gallate

(2020) Huimin Hou et al.   Biomed Research International

Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity

(2020) Justine R. Horne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China

(2020) Wen Zhang et al.   CLINICAL IMMUNOLOGY

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

COVID-19 cytokine storm: The anger of inflammation

(2020) Mehdi Mahmudpour et al.   CYTOKINE

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

(2020) Shivraj Hariram Nile et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SARS-CoV-2 and DPP4 inhibition: Is it time to pray for Janus Bifrons?

(2020) Dario Pitocco et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications

(2020) Daniel J Drucker   ENDOCRINE REVIEWS

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

(2020) Patricia Ruiz-Iglesias et al.   Nutrients

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 ( DPP4 ) in disease severity?

(2020) Margaret F. Bassendine et al.   Journal of Diabetes

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Interferon-α2b Treatment for COVID-19

(2020) Qiong Zhou et al.   Frontiers in Immunology

The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-κB/iNOS pathway in rats

(2020) X. Meng et al.   Physiology International

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

(2020) Da-Young Lee et al.   Antioxidants

Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19

(2020) Sebastiano Bruno Solerte et al.   ACTA DIABETOLOGICA

MAY PHYTOTHERAPY WITH POLYPHENOLS SERVE AS A POWERFUL APPROACH FOR THE PREVENTION AND THERAPY TOOL OF NOVEL CORONAVIRUS DISEASE 2019 (COVID-19)?

(2020) Emile Levy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting Cytokine Storm to Manage Patients with COVID-19: A Mini-Review

(2020) Neda Roshanravan et al.   ARCHIVES OF MEDICAL RESEARCH

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

(2020) Víctor J. Costela-Ruiz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV ‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study

(2020) Smarajit Maiti et al.   DRUG DEVELOPMENT RESEARCH

The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer

(2020) Veronica Mollica et al.   Future Oncology

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

(2020) Olga Abian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine

(2020) Muhammad Hamza et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Potential of Flavonoid-Inspired Phytomedicines against COVID-19

(2020) Wilfred Ngwa et al.   MOLECULES

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

(2020) Yu-Feng Huang et al.   PHARMACOLOGICAL RESEARCH

Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking

(2020) Xiaofeng Ruan et al.   Chinese Medicine

COVID-19: Underlying Adipokine Storm and Angiotensin 1-7 Umbrella

(2020) Geoffroy Méry et al.   Frontiers in Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity

(2020) Patricia Mendonca et al.   Antioxidants

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

(2020) Paolo Bellavite et al.   Antioxidants

Inhibitory effect of chestnut (Castanea mollissima Blume) inner skin extract on the activity of α-amylase, α-glucosidase, dipeptidyl peptidase IV and in vitro digestibility of starches

(2020) Yuyang Zhang et al.   FOOD CHEMISTRY

Implications of flavonoids as potential modulators of cancer neovascularity

(2020) Alena Liskova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

(2020) Marek Samec et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?

(2020) Niki Katsiki et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Could Sumac Be Effective on COVID-19 Treatment?

(2020) Hasan Korkmaz   JOURNAL OF MEDICINAL FOOD

Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from Millettia velutina

(2020) Xu Ma et al.   JOURNAL OF NATURAL PRODUCTS

The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions

(2020) Tapan Behl et al.   LIFE SCIENCES

Inflammation: A bridge between diabetes and COVID-19, and possible management with sitagliptin

(2020) Negin Mozafari et al.   MEDICAL HYPOTHESES

Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2

(2020) Muchtaridi Muchtaridi et al.   MOLECULES

Targeting inflammation and cytokine storm in COVID-19

(2020) Qianwen Huang et al.   PHARMACOLOGICAL RESEARCH

Can Activation of NRF2 Be a Strategy against COVID-19?

(2020) Antonio Cuadrado et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology

(2020) Ying Huang et al.   BioData Mining

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

(2020) Jia-Wen Song et al.   Chinese Medicine

ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle

(2020) Zaid Abassi et al.   Frontiers in Physiology

Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6

(2020) Wen-hao Niu et al.   BIOSCIENCE REPORTS

Linking ACE2 and angiotensin II to pulmonary immunovascular dysregulation in SARS-CoV-2 infection

(2020) S. Seltzer   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3

(2020) Tong Lin et al.   PHYTOMEDICINE

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

(2019) Kyuichi Kawabata et al.   MOLECULES

Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol®

(2019) Annelies Verlaet et al.   Nutrients

Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats

(2019) Sheila Estruel-Amades et al.   Nutrients

DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

(2019) Ming Zhong et al.   Virology Journal

Plant Natural Products for Human Health

(2019) Chun-Tao Che et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

(2019) Xin Jin et al.   CNS Neuroscience & Therapeutics

Kaempferol prevents against Ang II- induced cardiac remodeling via attenuating Ang II-induced inflammation and oxidative stress

(2019) Yao Du et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

(2019) Seri Jo et al.   Chemical Biology & Drug Design

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening

(2019) Andreia S.P. Pereira et al.   MOLECULES

Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

(2019) Nicola P. Bondonno et al.   Nature Communications

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways

(2019) Luís F. Mendes et al.   Scientific Reports

In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile

(2019) Luciana S. Salaverry et al.   JOURNAL OF ETHNOPHARMACOLOGY

Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and Toll-like receptor signalling

(2019) Li-jun Ling et al.   PHYTOMEDICINE

Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats

(2018) Chutamas Wunpathe et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Citrus bioflavonoids dipeptidyl peptidase-4 inhibition compared with gliptin antidiabetic medications

(2018) Ankit Gupta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

(2018) Gary Williamson et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities

(2018) Mouchira A. Choucry et al.   JOURNAL OF ETHNOPHARMACOLOGY

Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α

(2018) Fatma Hadrich et al.   Lipids in Health and Disease

Flavonoids and the gastrointestinal tract: Local and systemic effects

(2018) P.I. Oteiza et al.   MOLECULAR ASPECTS OF MEDICINE

Structure–Activity Relationship and Molecular Docking of Natural Product Library Reveal Chrysin as a Novel Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: An Integrated In Silico and In Vitro Study

(2018) Poonam Kalhotra et al.   MOLECULES

Flavonoids interfere with NLRP3 inflammasome activation

(2018) Hyun Lim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis

(2018) Yi Liu et al.   Frontiers in Pharmacology

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

(2018) Kai Wang et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults

(2018) Yan-Ru Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway

(2018) Yang Luo et al.   Oxidative Medicine and Cellular Longevity

Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H22 liver tumor-bearing mice

(2018) Li Chen et al.   Scientific Reports

Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model

(2018) Junliang Fei et al.   BIOMEDICINE & PHARMACOTHERAPY

Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress

(2018) Hao Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Isoliquiritigenin (ISL) and its formulations: potential antitumor agents

(2018) Ting-ting Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4

(2018) Takeshi Yokoyama et al.   FEBS Journal

Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination

(2018) Hanwen Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response

(2017) Aïcha Sassi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice

(2016) Un Jung et al.   Nutrients

A new antioxidant flavone glycoside fromScutellaria baicalensisGeorgi

(2014) Meng-Hua Wang et al.   NATURAL PRODUCT RESEARCH

A grape seed extract increases active glucagon-like peptide-1 levels after an oral glucose load in rats

(2014) Noemi González-Abuín et al.   Food & Function

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and Expression

(2012) Noemi González-Abuín et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro

(2012) So Young Kang et al.   JOURNAL OF MICROBIOLOGY

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

(2012) Sung Gu Han et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Flavonoids as anti-inflammatory agents

(2010) Mauro Serafini et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Elderberry flavonoids bind to and prevent H1N1 infection in vitro

(2009) Bill Roschek et al.   PHYTOCHEMISTRY