Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling

Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis

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Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy

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TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

(2020) Jie Su et al.   NATURE

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses

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Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

(2020) Zhixia Dong et al.   Annals of Translational Medicine

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

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iRhom2 promotes hepatic steatosis by activating MAP3K7‐dependent pathway

(2020) Minxuan Xu et al.   HEPATOLOGY

Role of NLRP3 inflammasome in liver diseases

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Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin

(2020) Chenxu Ge et al.   Redox Biology

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway

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The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice

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Hepatocyte TRAF6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lys6- Linked Polyubiquitination of ASK1

(2019) Yutao Wang et al.   HEPATOLOGY

Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson’s disease by promoting Wnt/β-catenin signaling pathway

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Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription

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(2018) Keywan Mortezaee   CELL BIOCHEMISTRY AND FUNCTION

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

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The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

(2018) Yan-Xiao Ji et al.   NATURE MEDICINE

Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway

(2018) Chao Yu et al.   Theranostics

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis

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Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2

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Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress

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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

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Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

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TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Transmembrane protein 88 attenuates liver fibrosis by promoting apoptosis and reversion of activated hepatic stellate cells

(2016) Shuang-Peng Cai et al.   MOLECULAR IMMUNOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells

(2016) Eun A. Ra et al.   Nature Communications

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

(2016) Shuang Liang et al.   Frontiers in Physiology

Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

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Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

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Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling

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Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models

(2012) Miloslav Polasek et al.   JOURNAL OF HEPATOLOGY

Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice

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Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells

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NF-κB in liver diseases: a target for drug therapy

(2008) Pablo Muriel   JOURNAL OF APPLIED TOXICOLOGY

Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein

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