Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 8, Pages 3195-3200Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.03.020
Keywords
Anti-inflammatory; Antioxidant; Anti-tyrosinase; Diarylpentanoids; iNOS
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Funding
- Ministry of Higher Education, Malaysia [01-01-07-013FR]
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A series of 46 curcumin related diarylpentanoid analogues were synthesized and evaluated for their antiinflammatory, antioxidant and anti-tyrosinase activities. Among these compounds 2,13 and 33 exhibited potent NO inhibitory effect on IFN-gamma/LPS-activated RAW 264.7 cells as compared to L-NAME and curcumin. However, these series of diarylpentanoid analogues were not significantly inhibiting NO scavenging, total radical scavenging and tyrosinase enzyme activities. The results revealed that the biological activity of these diarylpentanoid analogues is most likely due to their action mainly upon inflammatory mediator, inducible nitric oxide synthase (iNOS). The present results showed that compounds 2,13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents. (C) 2009 Elsevier Masson SAS. All rights reserved.
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