Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications

Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

(2022) Lisenn Lalier et al.   Biomolecules

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin

(2021) Xiao-ming Huang et al.   ACTA PHARMACOLOGICA SINICA

Targeting BRAF and RAS in Colorectal Cancer

(2021) Helene Bellio et al.   Cancers

Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress

(2021) Samantha N. Devenport et al.   JCI Insight

Targeting mutated GTPase KRAS in tumor therapies

(2021) Guangjin Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

(2021) Jing Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The significance of exosomes in the development and treatment of hepatocellular carcinoma

(2020) Xin Li et al.   Molecular Cancer

New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

(2020) Ritu Raj Singh et al.   DRUGS

Current therapy of KRAS-mutant lung cancer

(2020) Aron Ghimessy et al.   CANCER AND METASTASIS REVIEWS

Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and Future

(2020) Iris Z. Uras et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RAS-targeted therapies: is the undruggable drugged?

(2020) Amanda R. Moore et al.   NATURE REVIEWS DRUG DISCOVERY

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

(2020) Irem Ozkan-Dagliyan et al.   Cell Reports

Autophagy as a therapeutic target in pancreatic cancer

(2020) Max Piffoux et al.   BRITISH JOURNAL OF CANCER

Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway

(2020) Claudia Korzeniecki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting the untargetable KRAS in cancer therapy

(2019) Pingyu Liu et al.   Acta Pharmaceutica Sinica B

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

(2019) Chih-Shia Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

The Role of KRAS in Endometrial Cancer: A Mini-Review

(2019) MICHAIL SIDERIS et al.   ANTICANCER RESEARCH

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy

(2019) Ke Xu et al.   Molecular Cancer

Apoptosis, necroptosis and autophagy in colorectal cancer: Associations with tumor aggressiveness and p53 status

(2019) Fuminori Sakanashi et al.   PATHOLOGY RESEARCH AND PRACTICE

Autophagy as a molecular target for cancer treatment

(2019) Nur Mehpare Kocaturk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

(2019) Yan Dong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The superior efficacy of anti-PD-1/PD-L1 immunotherapy in KRAS-mutant non-small cell lung cancer that correlates with an inflammatory phenotype and increased immunogenicity

(2019) Chengming Liu et al.   CANCER LETTERS

Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors

(2019) Patrícia Dias Carvalho et al.   Cancers

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

(2018) Manuela Porru et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

KRAS -Mutant Non-Small Cell Lung Cancer: From Biology to Therapy

(2018) Irene Ferrer et al.   LUNG CANCER

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

(2018) Elaine Lai Han Leung et al.   Cell Death & Disease

The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis

(2018) Giulia Cazzanelli et al.   Cells

Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells

(2018) Rajpal S. Burmi et al.   CANCER BIOLOGY & THERAPY

Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas

(2018) Sandy Liu et al.   MODERN PATHOLOGY

Therapeutic strategies to target RAS-mutant cancers

(2018) Meagan B. Ryan et al.   Nature Reviews Clinical Oncology

The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status

(2018) Evangelos Koustas et al.   PLoS One

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

(2017) J Manent et al.   ONCOGENE

Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer

(2017) Niranjan Awasthi et al.   Oncotarget

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

(2017) Andrew M. Waters et al.   Cold Spring Harbor Perspectives in Medicine

Autophagy regulation and its role in gastric cancer and colorectal cancer

(2016) Huangyan Zhou et al.   Cancer Biomarkers

Ras Conformational Ensembles, Allostery, and Signaling

(2016) Shaoyong Lu et al.   CHEMICAL REVIEWS

Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer

(2016) Xiaomin Zhong et al.   MOLECULAR AND CELLULAR BIOLOGY

KRAS-related proteins in pancreatic cancer

(2016) Karen M. Mann et al.   PHARMACOLOGY & THERAPEUTICS

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells

(2016) Maria Goulielmaki et al.   Oncotarget

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737

(2015) Thibaud T. Renault et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The MutantKRASGene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism

(2015) Aziz Zaanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations

(2015) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

(2015) Sara Alves et al.   Oncotarget

Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance

(2015) Jie Sun et al.   Oncotarget

Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

(2014) A. N. Hata et al.   CANCER RESEARCH

Reversal of Mutant KRAS -Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells

(2014) Koichi Okamoto et al.   MOLECULAR CANCER RESEARCH

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

(2014) L. M. Lindqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T helper 17 cells play a critical pathogenic role in lung cancer

(2014) S. H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR inhibitors and autophagy in cancer treatment

(2014) Jie Cui et al.   TUMOR BIOLOGY

The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells

(2013) Ewelina Swiderek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Worse prognosis of KRASc.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx)

(2013) Gemma Bruera et al.   BMC Medicine

Depletion of K-Ras promotes proteasome degradation of survivin

(2013) Awet Tecleab et al.   CELL CYCLE

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Coexistent mutations ofKRASandPIK3CAaffect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer

(2013) Areumnuri Kim et al.   INTERNATIONAL JOURNAL OF CANCER

mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1

(2013) A. C. Faber et al.   Cancer Discovery

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

MicroRNA regulation of autophagy

(2012) L. B. Frankel et al.   CARCINOGENESIS

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers

(2012) Anurag Singh et al.   CELL

Signal Transduction Pathways of the Epidermal Growth Factor Receptor in Colorectal Cancer and their Inhibition by Small Molecules

(2012) T. Efferth   CURRENT MEDICINAL CHEMISTRY

The serrated pathway to colorectal carcinoma: current concepts and challenges

(2012) Mark Bettington et al.   HISTOPATHOLOGY

Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

(2012) Amanda K. Arrington et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAS Gene Mutation in Colorectal Cancer Is Correlated With Increased Proliferation and Spontaneous Apoptosis

(2011) Xiuli Liu et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autophagy: Regulation by Energy Sensing

(2011) Alfred J. Meijer et al.   CURRENT BIOLOGY

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Galectin-3 Mediates Cross-Talk between K-Ras and Let-7c Tumor Suppressor microRNA

(2011) Ran Levy et al.   PLoS One

Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

(2010) G Smith et al.   BRITISH JOURNAL OF CANCER

The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines

(2010) Ravi P. Sahu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Death pathways triggered by activated Ras in cancer cells

(2010) Jean et al.   Frontiers in Bioscience-Landmark

The Chromosomal Instability Pathway in Colon Cancer

(2010) Maria S. Pino et al.   GASTROENTEROLOGY

Clinical Relevance of KRAS in Human Cancers

(2010) Sylwia Jančík et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1a and HIF-2a target genes

(2010) Sang Y Chun et al.   Molecular Cancer

Galectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas

(2010) Ran Levy et al.   MOLECULAR CANCER THERAPEUTICS

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

(2010) Robert Schickel et al.   MOLECULAR CELL

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells

(2010) Muriel Priault et al.   PLoS One

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Active DNA Demethylation Mediated by DNA Glycosylases

(2009) Jian-Kang Zhu   Annual Review of Genetics

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

(2009) E. Martinelli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans

(2008) Sara Fröjdö et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL