Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis

(2021) Lisenn Lalier et al.   Cell Death & Disease

Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling: An Old Chap with New Roles

(2021) Jordan L. Morris et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein import and export across the bacterial outer membrane

(2021) Jérémy Guérin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

(2021) Jarrod J Sandow et al.   EMBO JOURNAL

The Diversity of the Mitochondrial Outer Membrane Protein Import Channels: Emerging Targets for Modulation

(2021) Monika Mazur et al.   MOLECULES

Lipids modulate the BH3-independent membrane targeting and activation of BAX and Bcl-xL

(2021) Victor Vasquez-Montes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites

(2021) Robert E. Means et al.   FEBS Journal

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

(2020) Tomomi Kuwana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipids distribution at mitochondria-associated membranes (MAM) upon induction of apoptosis.

(2020) Vincent Mignard et al.   JOURNAL OF LIPID RESEARCH

Cell Death in the Origin and Treatment of Cancer

(2020) Andreas Strasser et al.   MOLECULAR CELL

Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise

(2020) Alexandra G. Moyzis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

(2020) Nikolay Popgeorgiev et al.   Science Advances

Mechanisms and pathways of mitochondrial outer membrane protein biogenesis

(2020) Arushi Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Protein Import Dysfunction: Mitochondrial disease, Neurodegenerative Disease and Cancer

(2020) Catherine S. Palmer et al.   FEBS LETTERS

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice

(2019) Makoto Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

(2018) Colin Hockings et al.   CELL DEATH AND DIFFERENTIATION

Dissecting the thermodynamic contributions of the charged residues in the membrane anchoring of Bcl-xl C-terminal domain

(2018) Atanu Maity et al.   CHEMISTRY AND PHYSICS OF LIPIDS

VDAC2 enables BAX to mediate apoptosis and limit tumor development

(2018) Hui San Chin et al.   Nature Communications

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

(2017) Richard W. Birkinshaw et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BCL-XL directly modulates RAS signalling to favour cancer cell stemness

(2017) Sophie de Carné Trécesson et al.   Nature Communications

Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis

(2016) E Raemy et al.   CELL DEATH AND DIFFERENTIATION

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

(2016) Thomas P. Garner et al.   MOLECULAR CELL

The Human Bcl-2 Family Member Bcl-rambo Localizes to Mitochondria and Induces Apoptosis and Morphological Aberrations in Drosophila

(2016) Mako Nakazawa et al.   PLoS One

How does metabolism affect cell death in cancer?

(2015) Elodie Villa et al.   FEBS Journal

Regulation of Bax/mitochondria interaction by AKT

(2015) Lilit Simonyan et al.   FEBS LETTERS

Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737

(2015) Thibaud T. Renault et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tom70 Mediates Sendai Virus-Induced Apoptosis on Mitochondria

(2015) Bo Wei et al.   JOURNAL OF VIROLOGY

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)

(2015) Daniel O. Frank et al.   PLoS One

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis

(2014) Pierre-François Cartron et al.   CELLULAR SIGNALLING

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Non-apoptotic roles of Bcl-2 family: The calcium connection

(2013) Benjamin Bonneau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death

(2013) M A Jacquin et al.   CELL DEATH AND DIFFERENTIATION

BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis

(2013) Kathrin Weber et al.   Cell Reports

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

(2012) Meenu N. Perera et al.   BIOCHEMICAL JOURNAL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-xL: Keep your friends close but your enemies closer

(2012) Thibaud T. Renault et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evolution of Bcl-2 homology motifs: homology versus homoplasy

(2012) Abdel Aouacheria et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast

(2011) Thibaud T. Renault et al.   FEBS LETTERS

Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein

(2011) Byoung Heon Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandins antagonistically control Bax activation during apoptosis

(2010) L Lalier et al.   CELL DEATH AND DIFFERENTIATION

Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-xL

(2010) F. Gautier et al.   MOLECULAR AND CELLULAR BIOLOGY

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

(2010) Yehudit Zaltsman et al.   NATURE CELL BIOLOGY

Mosaic origin of the mitochondrial proteome

(2010) Radek Szklarczyk et al.   PROTEOMICS

The Akt isoforms are present at distinct subcellular locations

(2009) Stacey A. Santi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila

(2009) J. Colin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

(2009) Z X Chen et al.   CELL DEATH AND DIFFERENTIATION

TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFα-induced apoptosis

(2009) K Ross et al.   CELL DEATH AND DIFFERENTIATION

The mitochondrial outer membrane protein import machinery: a new player in apoptosis?

(2009) Elise Petit   Frontiers in Bioscience-Landmark

C-terminal Residues Regulate Localization and Function of the Antiapoptotic Protein Bfl-1

(2009) Gaelle Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation

(2009) Zhong-Jian Shen et al.   NATURE IMMUNOLOGY

BH3-only proteins and their roles in programmed cell death

(2009) M Giam et al.   ONCOGENE

Bax inserts into the mitochondrial outer membrane by different mechanisms

(2008) Pierre-François Cartron et al.   FEBS LETTERS

Cholesterol Effects on BAX Pore Activation

(2008) Eric Christenson et al.   JOURNAL OF MOLECULAR BIOLOGY