Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

(2016) Mingli Li et al.   BMC BIOLOGY

Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages

(2016) Caitlin E. Fogarty et al.   CURRENT BIOLOGY

Oncogene-mediated tumor transformation sensitizes cells to autophagy induction

(2016) RICARDO GARGINI et al.   ONCOLOGY REPORTS

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis

(2015) Zhihua Zhou et al.   EXPERIMENTAL CELL RESEARCH

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

(2015) Sara Alves et al.   Oncotarget

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

(2015) Wenjie Qin et al.   Oncotarget

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration

(2015) Paula Santabárbara-Ruiz et al.   PLoS Genetics

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation inDrosophila

(2015) Elena Morelli et al.   Autophagy

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila

(2015) Karen Doggett et al.   PLoS One

Ras and autophagy in cancer development and therapy.

(2015) Eran Schmukler et al.   Oncotarget

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

(2014) Michael J Morgan et al.   Autophagy

Assays to monitor autophagy in Drosophila

(2014) Caroline Mauvezin et al.   METHODS

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2014) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Chromosomal instability causes sensitivity to metabolic stress

(2014) Z Shaukat et al.   ONCOGENE

Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation

(2014) L Tomiyama et al.   ONCOGENE

Autophagy regulates tissue overgrowth in a context-dependent manner

(2014) E Pérez et al.   ONCOGENE

Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila

(2014) Mai Nakamura et al.   Nature Communications

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Tumor Suppression and Promotion by Autophagy

(2014) Yenniffer Ávalos et al.   Biomed Research International

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

(2013) A. Belaid et al.   CANCER RESEARCH

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling

(2013) P. Khoo et al.   Disease Models & Mechanisms

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Gene expression profiling analysis reveals that DLG3 is down-regulated in glioblastoma

(2013) Zhongyu Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Two-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher

(2013) Fergal O'Farrell et al.   PLOS BIOLOGY

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

(2013) Péter Nagy et al.   PLoS Genetics

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila

(2012) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007 – present)

(2012) Elena Sacco et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

ROS, autophagy, mitochondria and cancer: Ras, the hidden master?

(2012) Gregory L. Bellot et al.   MITOCHONDRION

Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

(2012) Shizue Ohsawa et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

(2011) Robin Mathew et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Identification of Novel Ras-Cooperating Oncogenes inDrosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

(2011) Anthony M. Brumby et al.   GENETICS

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model

(2011) M Willecke et al.   ONCOGENE

Ras-Induced Senescence and its Physiological Relevance in Cancer

(2010) T. DiMauro et al.   CURRENT CANCER DRUG TARGETS

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

(2009) Gregory R Leong et al.   BMC BIOLOGY

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE