Article
Genetics & Heredity
Ana Martinez-Abarca Millan, Jennifer Soler Beatty, Andrea Valencia Exposito, Maria D. Martin-Bermudo
Summary: Oncogenic mutations in the Ras gene contribute to 30% of human cancers, but additional mutations are needed for tumor progression. The tensin family of proteins have been found to regulate carcinogenesis, but their role in cancer is still controversial. Using the Drosophila wing imaginal disc as a model, researchers found that eliminating certain tensin proteins potentiates Ras-driven tissue overgrowth, suggesting that tensins may act as suppressors of cancer progression.
Article
Chemistry, Multidisciplinary
Wang Yao, Chuan-Jun Lu, Li-Wen Zhan, Yi Wu, Jia Feng, Ren-Rong Liu
Summary: In this study, a palladium-catalyzed enantioselective C-H activation method for pyrroles was reported, which successfully synthesized structurally diverse indole-pyrrole atropisomers with a chiral N-N axis, showing high yields and enantioselectivities. Furthermore, the kinetic resolution of trisubstituted N-N heterobiaryls with more sterically demanding substituents was also achieved. This versatile method enables the rapid and selective functionalization of pyrroles, facilitating the synthesis of valuable and complex N-N atropisomers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Oncology
Anthony P. Y. Liu, Paul A. Northcott
Summary: This study summarizes the high expression of FOXR2 in various cancers, uncovers a previously unknown mechanism of epigenetic activation, and expands the transcriptional targets of FOXR2. It enhances the understanding of FOXR2-driven malignancy and has the potential to discover new therapeutic opportunities.
Review
Cell Biology
Anna Pegoraro, Elena De Marchi, Elena Adinolfi
Summary: The human P2X7 gene plays a significant role in oncological conditions, particularly in isoform B and nfP2X7. Research suggests that P2X7 variants could potentially serve as new biomarkers and therapeutic targets in cancer.
Article
Biochemistry & Molecular Biology
Jiyu Miao, Changan Zhao, Kaijie Tang, Xiaofan Xiong, Fei Wu, Wanjuan Xue, Baojun Duan, Huahua Zhang, Xintao Jing, Wen Li, Ying Sun, Ni Hou, Chen Huang
Summary: The study reveals that TDG inhibits the migration and invasion of human colon cancer cells by promoting the degradation of DNMT3A and regulating the expression of TIMP2. This finding suggests that targeting the TDG-DNMT3A-TIMP2 axis may be a potential therapeutic strategy for colorectal cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Summary: Immune cells play a role in protecting against tumor progression, while aberrant expression of PD-L1 in cancer cells leads to tumor immune escape. This study found that ING4 induces the autophagic degradation of PD-L1, inhibiting immune escape in NSCLC. However, high expression of CK2 was found to correlate with low ING4 protein levels in NSCLC. Further analysis revealed that CK2 induces the phosphorylation of ING4-S150, leading to its degradation by JFK ubiquitin ligase. In contrast, CK2 gene knockout increased ING4 protein stability and T cell activity, inhibiting NSCLC immune escape. Additionally, the combination of a CK2 inhibitor and PD-1 antibody effectively enhanced antitumor immunotherapy.
Article
Engineering, Environmental
Yuanbo Yao, Huixia Yang, Yunyun Wang
Summary: Supersaturated total dissolved gas generation in rivers poses great harm to aquatic organisms. This study establishes a quantitative relationship between supersaturated TDG dissipation coefficients and aeration conditions, and provides insights into the variations and influencing factors of the dissipation coefficients.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Water Resources
Yujuan Mo, Hang Wan, Yanpeng Cai, Xiaodong Zhang, Ran Li, Yongyang Wang
Summary: By establishing an eco-friendly reservoir operation model, the study aims to reduce the supersaturated total dissolved gas (TDG) level and increase reservoir flow velocity in order to restore fish migration pathways.
JOURNAL OF HYDROLOGY-REGIONAL STUDIES
(2023)
Article
Multidisciplinary Sciences
C. Fernandez-Rozadilla, M. Alvarez-Barona, I Quintana, A. Lopez-Novo, J. Amigo, J. M. Cameselle-Teijeiro, E. Roman, D. Gonzalez, X. Llor, L. Bujanda, X. Bessa, R. Jover, F. Balaguer, A. Castells, S. Castellvi-Bel, G. Capella, A. Carracedo, L. Valle, Clara Ruiz-Ponte
Summary: The study aimed to identify novel genetic variants associated with early-onset CRC by sequencing patients and searching for rare, high-impact variants in selected genes. Although a recurring truncating variant was found, no promising CRC predisposing genes were identified. The study suggested that CRC onset may be oligogenic and potential risk alleles tend to appear more frequently in younger cases. Larger and robust studies are needed to unravel the genetics behind early-onset CRC development.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Arathi Nair, Katharina F. Kubatzky, Bhaskar Saha
Summary: The Ras GTPase plays a central role in oncogenic circuitry, with its isoforms H-, K-, and N-Ras exhibiting functional differences and cell type-specific activities. The preferential localization of different Ras isoforms in various cellular compartments adds a new dimension to isoform-specific signaling and diverse functions. Therefore, considering isoform-specific properties in the design of therapeutic strategies is crucial for effective treatments in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Guoliang Wang, Yinwen Zhou, Bin Yi, Yanli Long, Bo Ma, Yi Zhang
Summary: Epigenetics, specifically DNA methylation, plays a crucial role in the malignant progression of tumors. Thymine-DNA glycosylase (TDG), a key regulator in DNA demethylation, has been found to be highly expressed in hepatocellular carcinoma (HCC) and is associated with poor prognosis. The study demonstrates that decreasing TDG expression can effectively inhibit the malignant behavior of HCC cells, with ABL proto-oncogene 1 (ABL1) identified as a downstream gene regulated by TDG demethylation. Additionally, TDG affects the Hippo signaling pathway through ABL1, exerting its regulatory role in HCC cell proliferation, apoptosis, invasion, and migration.
Article
Biochemistry & Molecular Biology
Zihang Zeng, Tiao Li, Xiangming Liu, Yiming Ma, Lijuan Luo, Zuli Wang, Zhiqi Zhao, Herui Li, Xue He, Huihui Zeng, Yongguang Tao, Yan Chen
Summary: This study reveals that TET2 plays a role in regulating lipid peroxidation and ferroptosis in airway epithelial cells in COPD. Reduced levels of TET2 exacerbate CS-induced pulmonary diseases, while overexpression of TET2 inhibits ferroptosis. This research provides a potential therapeutic target for the treatment of COPD.
Review
Virology
Xiaorui Zuo, Ruoning Zhou, Sikai Yang, Guangyong Ma
Summary: HTLV-1 is an oncogenic retrovirus that mainly persists in the infected host cell as a provirus; it also causes a malignancy called adult T-cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV-1 replication is silent in vivo and relies on clonal proliferation of infected T cells for viral propagation. The mechanism of leukemic clone formation and ATLL onset during HTLV-1 infection is still unclear. This review summarizes the current understanding of HTLV-1 persistence and oncogenesis, incorporating recent cutting-edge discoveries obtained by high-throughput sequencing.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Genetics & Heredity
Sanne Bootsma, Sanne M. van Neerven, Louis Vermeulen
Summary: Half of colorectal cancers have KRAS-activating mutations, which affect cancer cells' metabolic dependencies and lead to resistance to common drugs. A new study reveals the metabolic rewiring driven by KRAS and identifies a new therapeutic target for KRAS-mutant cancers.
Review
Cell Biology
Dongjun Dai, Hanying Wang, Liyuan Zhu, Hongchuan Jin, Xian Wang
CELL DEATH & DISEASE
(2018)
Article
Oncology
Yimin Zhu, Hanlin Lu, Dandan Zhang, Meiyan Li, Xiaohui Sun, Ledong Wan, Dan Yu, Yiping Tian, Hongchuan Jin, Aifen Lin, Fei Gao, Maode Lai
CLINICAL EPIGENETICS
(2018)
Article
Plant Sciences
Yuhua Li, Yang Sun, Tianle Tang, Yinbo Niu, Xiaoqiang Li, Ming Xie, Hongchuan Jin, Qibing Mei
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Cell Biology
Vivian Yvonne Shin, Jiawei Chen, Isabella Wai-Yin Cheuk, Man-Ting Siu, Chi-Wang Ho, Xian Wang, Hongchuan Jin, Ava Kwong
CELL DEATH & DISEASE
(2019)
Article
Gastroenterology & Hepatology
Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, Feng Wu, Otto Ka-Wing Cheung, Hanyong Sun, Xuezhen Zeng, Wenshu Tang, Myth T. S. Mok, John Wong, Philip Chun Yeung, Paul Bo San Lai, Zhiwei Chen, Hongchuan Jin, Jie Chen, Stephen Lam Chan, Anthony W. H. Chan, Ka Fai To, Joseph J. Y. Sung, Minhu Chen, Alfred Sze-Lok Cheng
Article
Cell Biology
Neelum Aziz Yousafzai, Qiyin Zhou, Wenxia Xu, Qiqi Shi, Jinye Xu, Lifeng Fenq, Hui Chen, Vivian Yvonne Shin, Hongchuan Jin, Xian Wang
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Liyuan Zhu, Yiran Zhu, Shuting Han, Miaoqin Chen, Ping Song, Dongjun Dai, Wenxia Xu, Tingting Jiang, Lifeng Feng, Vivian Y. Shin, Xian Wang, Hongchuan Jin
CELL DEATH & DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Yan Cui, Susann Groth, Scott Troutman, Annemarie Carlstedt, Tobias Sperka, Lars Bjorn Riecken, Joseph L. Kissil, Hongchuan Jin, Helen Morrison
Article
Multidisciplinary Sciences
Kuo-Liang Wei, Jian-Liang Chou, Yin-Chen Chen, Hongchuan Jin, Yu-Min Chuang, Cheng-Shyong Wu, Michael W. Y. Chan
Article
Multidisciplinary Sciences
Dongjun Dai, Yiming Zhong, Zhuo Wang, Neelum Aziz Yousafzai, Hongchuan Jin, Xian Wang
Article
Chemistry, Medicinal
Heping Zhu, Shilong Ying, Bingluo Zhou, Xiao Liang, Quan He, Ping Song, Xinyang Hu, Keqiang Shi, Mingteng Xiong, Hongchuan Jin, Yuanjiang Pan
Summary: A series of novel 2-aryl-3-sulfonamido-pyridines (HoAns) compounds were designed, synthesized, and evaluated for their antiproliferative activities, with HoAn32 demonstrating the most potent activity and microtubule-targeting effect in cancer cell lines. Mechanism studies showed that HoAn32 bound to the colchicine site of b-tubulin, resulting in multiple anti-cancer effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Heping Zhu, Shilong Ying, Bingluo Zhou, Xinyang Hu, Xiao Liang, Wangyu Li, Dungai Wang, Hongchuan Jin, Yuanjiang Pan
Summary: A novel compound ID-11 was designed and synthesized to effectively inhibit the proliferation of CRC cells while showing minimal impact on normal colon epithelial cells. Mechanism studies suggest that ID-11 may inhibit CRC cell proliferation through multiple pathways, and it exhibits favorable pharmacokinetic properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jinye Xu, Qiqi Shi, Wenxia Xu, Qiyin Zhou, Rongkai Shi, Yanning Ma, Dingwei Chen, Liyuan Zhu, Lifeng Feng, Alfred Sze-Lok Cheng, Helen Morrison, Xian Wang, Hongchuan Jin
Article
Medicine, Research & Experimental
Qiyin Zhou, Hua Li, Yuanyuan Li, Mingjia Tan, Shaohua Fan, Cong Cao, Feilong Meng, Ling Zhu, Lili Zhao, Min-Xin Guan, Hongchuan Jin, Yi Sun
Review
Oncology
Dongjun Dai, Bingluo Zhou, Wenxia Xu, Hongchuan Jin, Xian Wang