The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis

Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5

(2017) Soneya Majumdar et al.   FEBS Journal

Yeast buddies helping to unravel the complexity of neurodegenerative disorders

(2017) Gernot Fruhmann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

Efforts to make and apply humanized yeast

(2015) Jon M. Laurent et al.   Briefings in Functional Genomics

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

(2015) Sara Alves et al.   Oncotarget

Ras-Related Tumorigenesis Is Suppressed by BNIP3-Mediated Autophagy through Inhibition of Cell Proliferation

(2015) Shan-Ying Wu et al.   NEOPLASIA

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

Targeting mTOR network in colorectal cancer therapy

(2014) Xiao-Wen Wang   WORLD JOURNAL OF GASTROENTEROLOGY

The Reference Genome Sequence of Saccharomyces cerevisiae : Then and Now

(2014) Stacia R. Engel et al.   G3-Genes Genomes Genetics

Ras/PKA signal transduction pathway participates in the regulation ofSaccharomyces cerevisiaecell apoptosis in an acidic environment

(2013) Eglė Lastauskienė et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2

(2013) Nicoletta Guaragnella et al.   FEMS YEAST RESEARCH

Ras/cAMP-dependent Protein Kinase (PKA) Regulates Multiple Aspects of Cellular Events by Phosphorylating the Whi3 Cell Cycle Regulator in Budding Yeast

(2013) Masaki Mizunuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ammonium-Dependent Shortening of CLS in Yeast Cells Starved for Essential Amino Acids Is Determined by the Specific Amino Acid Deprived, through Different Signaling Pathways

(2013) Júlia Santos et al.   Oxidative Medicine and Cellular Longevity

The Evolutionary Portrait of Metazoan NAD Salvage

(2013) João Carneiro et al.   PLoS One

Nuclear Ras2-GTP Controls Invasive Growth in Saccharomyces cerevisiae

(2013) Serena Broggi et al.   PLoS One

Localization of Ras signaling complex in budding yeast

(2012) Fiorella Belotti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Saccharomyces cerevisiae as a model system to study the response to anticancer agents

(2012) Renata Matuo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Signal Transduction Pathways of the Epidermal Growth Factor Receptor in Colorectal Cancer and their Inhibition by Small Molecules

(2012) T. Efferth   CURRENT MEDICINAL CHEMISTRY

New insights into cancer-related proteins provided by the yeast model

(2012) Clara Pereira et al.   FEBS Journal

Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer

(2012) Amanda K. Arrington et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras–Raf–Erk1/2 pathway

(2012) Keng-Liang Wu et al.   JOURNAL OF GASTROENTEROLOGY

Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan

(2012) Júlia Santos et al.   PLoS One

Overexpressed Galectin-3 in Pancreatic Cancer Induces Cell Proliferation and Invasion by Binding Ras and Activating Ras Signaling

(2012) Shumei Song et al.   PLoS One

KRAS Gene Mutation in Colorectal Cancer Is Correlated With Increased Proliferation and Spontaneous Apoptosis

(2011) Xiuli Liu et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Involvement of mitophagy in oncogenic K-Ras-induced transformation

(2011) June-Hyung Kim et al.   Autophagy

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autophagy: Regulation by Energy Sensing

(2011) Alfred J. Meijer et al.   CURRENT BIOLOGY

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

(2011) Isabel Coutinho et al.   EXPERIMENTAL CELL RESEARCH

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Yeast: An Experimental Organism for 21st Century Biology

(2011) David Botstein et al.   GENETICS

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation

(2011) Ian M. Ahearn et al.   MOLECULAR CELL

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

(2011) A. T. Sasaki et al.   Science Signaling

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane

(2010) Pinkesh Bhagatji et al.   BIOPHYSICAL JOURNAL

Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

(2010) G Smith et al.   BRITISH JOURNAL OF CANCER

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

Colorectal cancer in review: the role of the EGFR pathway

(2010) Muhammad W Saif   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

(2010) Anna I. Markowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Galectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas

(2010) Ran Levy et al.   MOLECULAR CANCER THERAPEUTICS

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose Signaling-Mediated Coordination of Cell Growth and Cell Cycle in Saccharomyces Cerevisiae

(2010) Stefano Busti et al.   SENSORS

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Regulation of autophagy in yeast Saccharomyces cerevisiae

(2009) Eduardo Cebollero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

(2009) Luísa Azevedo et al.   BMC GENOMICS

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

(2009) E. Martinelli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes

(2009) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC

(2009) Nicola Normanno et al.   Nature Reviews Clinical Oncology

Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators

(2009) Hideki Hayashi et al.   PLoS One

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

(2009) J. S. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HowSaccharomycesResponds to Nutrients

(2008) Shadia Zaman et al.   Annual Review of Genetics

TOR regulation of AGC kinases in yeast and mammals

(2008) Estela Jacinto et al.   BIOCHEMICAL JOURNAL

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

(2008) R. Shalom-Feuerstein et al.   CANCER RESEARCH

To Die or Not to Die: That is the Autophagic Question

(2008) Maria Maiuri et al.   CURRENT MOLECULAR MEDICINE

The Ras/cAMP Pathway and the CDK-Like Kinase Ime2 Regulate the MAPK Smk1 and Spore Morphogenesis in Saccharomyces cerevisiae

(2008) C. M. McDonald et al.   GENETICS

Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers

(2008) Ludovic Barault et al.   INTERNATIONAL JOURNAL OF CANCER

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coactivator requirements for p53-dependent transcription in the yeastSaccharomyces cerevisiae

(2007) Ahmed F. Yousef et al.   INTERNATIONAL JOURNAL OF CANCER