Article
Multidisciplinary Sciences
Ling-Zhen Liu, Long Liu, Zhi- Hong Shi, Xian-Ling Bian, Zi-Ru Si, Qi- Quan Wang, Yang Xiang, Yun Zhang
Summary: We reported the identification of a regulated pore-forming protein (3 beta-CAT and trefoil factor complex in Bombina maxima cells, which is secreted under glucose, glutamine, and pyruvate deficiency for nutrient acquisition and survival. AMPK signaling positively regulates (3 beta-CAT expression and secretion. The complex selectively binds extracellular proteins and promotes protein uptake through endolysosomal pathways. These findings provide new insights into cell nutrient scavenging and metabolic flexibility.
Article
Multidisciplinary Sciences
Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J. Hussey, Pengwei Wang
Summary: ER-mitochondrial contact sites (EMCSs) are essential for mitochondrial function. The EMCS complex, consisting of TRB1, TRB2, and VAP27-1, plays a dual role in regulating the interaction between mitochondria and the ER as well as mitophagy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Aida Rodriguez-Nuevo, Ariadna Torres-Sanchez, Juan M. Duran, Cristian De Guirior, Maria Angeles Martinez-Zamora, Elvan Boke
Summary: Oocytes evade the negative effects of reactive oxygen species (ROS) by eliminating complex I in the mitochondrial electron transport chain. Early oocytes have low levels of complex I and an active mitochondrial unfolded protein response. This suppression of complex I represents a strategy for maintaining biological activity while achieving longevity.
Article
Environmental Sciences
Zhongmin Sui, Chaoqing Wei, Xuan Wang, Huihui Zhou, Chengdong Liu, Kangsen Mai, Gen He
Summary: Ammonia has significant impacts on the growth and health of crustaceans, leading to oxidative stress and metabolic disorders. However, little is known about its effects on nutrient metabolism and signaling pathways. This study provides important insights into the metabolic responses and nutrient signaling under ammonia stress, enhancing our understanding of the physiological responses and growth performance in shrimp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Mei-Xin Li, Xiao-Ting Wu, Wen-Qiang Jing, Wen-Kui Hou, Sheng Hu, Wei Yan
Summary: Metabolic heterogeneity of tumor microenvironment is a big challenge in cancer treatment. This study explores the role of inosine in regulating mitochondrial metabolism and promoting cancer cell survival in nutrient-poor regions. Inosine elevation induces the abundance of Rag GTPases and mTORC1 signaling pathway, stimulates the synthesis of TCA cycle enzymes, and enhances oxidative phosphorylation in breast cancer cells under glucose starvation. Inhibition of citrate synthesis or knockdown of aconitase 1 blocks the rescue effect of inosine on cancer survival. These findings provide insights into targeting inosine metabolism for future cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li, Ying Meng
Summary: This study demonstrates that cigarette smoke activates lung fibroblasts by increasing mtROS and impairing autophagy flux, leading to dysregulated lipid metabolism. These findings may provide therapeutic targets for patients with idiopathic pulmonary fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ines C. M. Simoes, Ricardo Amorim, Jose Teixeira, Agnieszka Karkucinska-Wieckowska, Adriana Carvalho, Susana P. Pereira, Rui F. Simoes, Sylwia Szymanska, Michal Dabrowski, Justyna Janikiewicz, Agnieszka Dobrzyn, Paulo J. Oliveira, Yaiza Potes, Mariusz R. Wieckowski
Summary: This study revealed that the progression of non-alcoholic fatty liver disease (NAFLD) involves mitochondrial dysfunction and ROS generation mediated by peroxisomes, rather than excessive mitochondrial ROS production, as previously thought.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ciro Menale, Giovanna Trinchese, Immacolata Aiello, Giulia Scalia, Monica Dentice, Maria Pina Mollica, Nal Ae Yoon, Sabrina Diano
Summary: In this study, it was found that the addition of non-lipotoxic levels of 25 μM palmitic acid (PA) to glucose (G) increased mineralization in osteoblasts (OBs). It was also discovered that G+25 μM PA reduced mitochondria size in OBs and increased mitochondria respiration and ATP production, as well as the expression of oxidative phosphorylation genes. Treatment with the mitochondrial fission inhibitor Mdivi-1 reduced osteogenesis and mitochondrial respiration in OBs.
Article
Cell Biology
Cristina Cueto-Urena, Enric Mocholi, Josep Escriva-Fernandez, Susana Gonzalez-Granero, Sabina Sanchez-Hernandez, Amalia Solana-Orts, Begona Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, Jose Manuel Garcia-Verdugo, Francisco Martin, Paul J. Coffer, Ignacio Perez-Roger, Enric Poch
Summary: This study reveals that loss of Rnd3 expression affects mitochondrial oxidative metabolism and renders cells dependent on glycolysis for energy, suggesting a possible connection to neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Boyuan Ma, Anji Ju, Shaosen Zhang, Qi An, Siran Xu, Jie Liu, Li Yu, Yan Fu, Yongzhang Luo
Summary: Hepatic mitochondrial dysfunction contributes to the progression of NAFLD. This study reveals that albumosome, a shell-like structure formed by pre-folding albumin in the cytoplasm, plays a crucial role in maintaining mitochondrial homeostasis and preventing mitochondrial damage. Albumosomes interact with and trap pre-folding CPT2, controlling its excessive sorting to the mitochondria under high-fat-diet-induced stress conditions. Accumulation of albumosomes in hepatocytes during aging protects the liver from mitochondrial damage and fat deposition.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shengnan Ren, Dingquan Yang, Yongli Dong, Weidong Ni, Meiqi Wang, Lei Xing, Tong Liu, Wenjia Hou, Weixuan Sun, Haolong Zhang, Zhentao Yu, Yi Liu, Jingrui Cao, Hongbo Yan, Ye Feng, Xuedong Fang, Quan Wang, Fangfang Chen
Summary: This study identified Protamine 1 (PRM1) as a specific antigen related to colorectal cancer (CRC) and demonstrated its potential as a promising diagnostic marker. It also revealed the role of PRM1 in regulating cellular growth under nutrient deficiency.
Article
Cell Biology
He Yan, Menglong Zhuang, Xiaoyu Xu, Shanshan Li, Mingkang Yang, Nianle Li, Xiaojuan Du, Kangwei Hu, Xiaomin Peng, Wei Huang, Hong Wu, Yu Chung Tse, Lifeng Zhao, Hao Wang
Summary: The study reveals that autophagy plays a significant role in plant sexual reproduction and is essential for pollen tube growth and male fertility in Arabidopsis. Additionally, the research demonstrates the interaction between autophagosomes and prevacuolar compartments and the involvement of autophagy in mitochondrial quality control.
Article
Biochemistry & Molecular Biology
Maryam Adelipour, Leena Regi Saleth, Saeid Ghavami, Keshav Narayan Alagarsamy, Sanjiv Dhingra, Abdolamir Allameh
Summary: This article discusses the importance of autophagy in maintaining cellular homeostasis and stem cell function, and emphasizes the potential of modulating autophagy as a therapeutic approach for cancer and other diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Siqi Liu, Shanshan Liu, Baiyu He, Lanlan Li, Lin Li, Jiawen Wang, Tao Cai, She Chen, Hui Jiang
Summary: The research reveals that yeast mutants deficient in certain oxidative phosphorylation complexes and mtDNA exhibit progressive reduction of mitochondrial membrane potential. These mutants activate adaptive responses, including remodeling of mitochondrial proteome and reshaping of cellular metabolism.
Article
Cell Biology
Morgan A. Gingerich, Xueying Liu, Biaoxin Chai, Gemma L. Pearson, Michael P. Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour
Summary: CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. This study reveals the importance of a C-terminal intrinsically disordered protein region (IDPR) in CLEC16A for mitochondrial quality control. The stability of CLEC16A is dependent on proline bias within the C-terminal IDPR.
Review
Biochemistry & Molecular Biology
Zeribe Chike Nwosu, Mun Gu Song, Marina Pasca di Magliano, Costas A. A. Lyssiotis, Sung Eun Kim
Summary: Cancer cells depend on specific extracellular nutrients for their metabolism and growth. SLC transporters play a crucial role in acquiring these nutrients and transferring intracellular nutrients. Understanding the function of SLC transporters in cancer could provide therapeutic targets for effective treatment.
Article
Multidisciplinary Sciences
Pattaraporn Thepsuwan, Asmita Bhattacharya, Zhenfeng Song, Stephen Hippleheuser, Shaobin Feng, Xiaoqiong Wei, Nupur K. Das, Mariana Sierra, Juncheng Wei, Deyu Fang, Yu-Ming M. Huang, Kezhong Zhang, Yatrik M. Shah, Shengyi Sun
Summary: The SEL1L-HRD1 protein complex of endoplasmic reticulum-associated degradation (ERAD) in hepatocytes controls systemic iron homeostasis through regulating ceruloplasmin (CP), a ferroxidase involved in iron distribution. The absence of ERAD leads to accumulation of CP in the ER and increased secretion, affecting iron distribution and oxidation status.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Civil
Seyed Masoud Soleimanpour, Hamid Gholami, Omid Rahmati, Samad Shadfar
Summary: This study quantifies the contributions of four individual sediment sources using the GLUE method and two statistical processes. The results showed that GLUE with the RTM-KW-DFA process was more accurate. Overall, Sediment Source Fingerprinting (SSF) within the GLUE framework is a useful tool for identifying sediment sources in different catchments.
WATER RESOURCES MANAGEMENT
(2023)
Article
Chemistry, Multidisciplinary
Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue
Summary: This study reveals that transferrin receptor (TFRC) is induced by β-catenin activation driven by APC gene loss in colorectal cancer, and TFRC-mediated intratumoral iron accumulation enhances β-catenin signaling through tankyrase activation. Disruption of TFRC reduces colonic iron levels and iron-dependent tankyrase activity, leading to stabilization of AXIN2 and repression of the β-catenin/c-Myc/E2F Transcription Factor 1/DNA polymerase delta1 (POLD1) axis, causing increased DNA replication stress, DNA damage response, apoptosis, and reduced colon tumor growth. Iron chelation combined with DNA damaging agents further increases DNA damage response and reduces colon tumor cell growth. This discovery may offer new strategies for colorectal cancer therapy.
Editorial Material
Endocrinology & Metabolism
Yumi Imai, Scott A. Soleimanpour, Jeffery S. Tessem
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Mack B. Reynolds, Hanna S. Hong, Britton C. Michmerhuizen, Anna-Lisa E. Lawrence, Li Zhang, Jason S. Knight, Costas A. Lyssiotis, Basel H. Abuaita, Mary X. O'Riordan
Summary: Macrophage metabolic plasticity allows the redirection of electron transport for inflammation and host defense. Inflammatory activation leads to disassembly of Complex II and loss of succinate dehydrogenase subunit B through sequestration and selective mitophagy. The regulatory role of cardiolipin in coordinating Complex II function and inflammatory metabolic remodeling is demonstrated.
Article
Biochemistry & Molecular Biology
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Wenqing Feng, Xiaoyue Sun, Geoffrey E. Hespe, Zijun Wang, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Evan T. Keller, Jun Ma, Jung-Sun Cho, Jingwen Yang, Stephen J. Weiss
Summary: Osteoclasts undergo transcriptional and metabolic changes during differentiation to acquire the cellular machinery for bone resorption. Zeb1, a zinc-finger transcriptional repressor, is found to play a role in osteoclast energy metabolism. By repressing a crucial enzyme involved in ATP buffering and mitochondrial respiration, Zeb1 controls the activity of osteoclasts and influences bone remodeling. This study reveals a novel Zeb1/MtCK1 axis that regulates bone resorption through metabolic control.
Article
Biochemistry & Molecular Biology
Brandon Chen, Nupur K. Das, Indrani Talukder, Rashi Singhal, Cristina Castillo, Anthony Andren, Joseph D. Mancias, Costas A. Lyssiotis, Yatrik M. Shah
Summary: PINK1 plays a positive role in colorectal cancer by promoting tumor survival and growth through regulating mitophagy and ferritinophagy pathways, which regulate intracellular iron availability and stability.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Xiaoyue Sun, Zijun Wang, Jung-Sun Cho, Jun Ma, Stephen J. Weiss
Summary: The interaction between metalloproteins Mmp9 and Mmp14 and carbohydrate-binding protein galectin-3 plays a critical role in osteoclast-mediated bone resorption. The ability of Mmp9 and Mmp14 to degrade galectin-3 on the cell surface depends on its binding protein Lrp-1. These findings reveal a previously unrecognized galectin-3/Lrp1 axis that regulates both the transcriptional programs and intracellular signaling cascades essential for osteoclast function.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Environmental Sciences
Omid Rahmati, Seyed Masoud Soleimanpour, Mahmood Arabkhedri, Sardar Mehrjo, Zahra Kalantari, Marco Cavalli, Stefano Crema, Aref Bahmani
Summary: This study investigated the performance of contour trenching program, a nature-based solution for soil erosion prevention in the hillslopes of Khamsan watershed in Iran. The results showed that contour trenching significantly reduced sediment connectivity and improved soil conservation. The study highlights the importance of contour trenching program in reducing soil erosion.
JOURNAL OF SOILS AND SEDIMENTS
(2023)
Article
Environmental Sciences
Omid Rahmati, Seyed Masoud Soleimanpour, Samad Shadfar, Salahudin Zahedi
Summary: This study aimed to predict gully susceptibility hotspots using hybridized deep-learning models and evaluate their efficiency. Results showed that the NNC-GWO model had the highest accuracy (AUC = 97.2%), followed by the NNC-ICA model (AUC = 95.1%). The standalone NNC model had the lowest accuracy (AUC = 91.2%) in predicting gully susceptibility hotspots. Therefore, the hybridized models performed better in identifying gully susceptibility compared to the standalone NNC model.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Hematology
Chesta Jain, Sanjana Parirai, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah
Summary: Dietary consumption is the primary source of iron uptake, and erythropoiesis regulates systemic iron demand. Macrophages are crucial in recycling iron and intestinal absorption. Kidneys produce erythropoietin, while the liver produces the iron-regulatory hormone hepcidin. Hypoxia-inducible factor HIF2a plays a central role in coordinating tissue communication for iron homeostasis. The exact involvement of Hif2a in macrophages regarding iron homeostasis remains uncertain.
EXPERIMENTAL HEMATOLOGY
(2023)
Article
Materials Science, Biomaterials
Elizabeth Bealer, Kelly Crumley, Daniel Clough, Jessica King, Maya Behrend, Connor Annulis, Feiran Li, Scott Soleimanpour, Lonnie D. Shea
Summary: Studies have shown that three-dimensional cell culture of human stem cell-derived islet organoids can improve cell differentiation and function. Transplantation of these organoids into extrahepatic sites reduces hyperglycemia.
BIOMATERIALS SCIENCE
(2023)