Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

(2021) Maheedhar Kodali et al.   AGING CELL

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke

(2021) Yong-Ming Zhu et al.   Translational Stroke Research

Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats

(2021) Gintare Zemgulyte et al.   Pharmaceuticals

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6

(2020) Chaojun Han et al.   BRAIN BEHAVIOR AND IMMUNITY

Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

(2020) Xiaoling Chen et al.   NEUROPHARMACOLOGY

Neuroprotective effects of magnesium l-threonate in a hypoxic zebrafish model

(2020) Young-Sung Kim et al.   BMC NEUROSCIENCE

Association of prestroke metformin use, stroke severity, and thrombolysis outcome

(2020) Laura P. Westphal et al.   NEUROLOGY

Acute Ischemic Stroke

(2020) William J. Powers   NEW ENGLAND JOURNAL OF MEDICINE

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

(2020) Jeanine L. Van Nostrand et al.   GENES & DEVELOPMENT

Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/β-catenin signaling pathway

(2020) Tao Zhang et al.   NEUROSCIENCE LETTERS

Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient

(2020) Teerapat Nantsupawat et al.   Cardiovascular Diabetology

Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress

(2019) Min Zhao et al.   MEDICAL SCIENCE MONITOR

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling

(2019) Chi-Cheng Lu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

(2019) Chao-jun Han et al.   ACTA PHARMACOLOGICA SINICA

The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury

(2019) Tom Leech et al.   PHARMACOLOGICAL RESEARCH

Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway

(2018) Juan Ji et al.   AGING CELL

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Antidiabetic drugs and stroke risk. Current evidence

(2018) Luis Castilla-Guerra et al.   European Journal of Internal Medicine

Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke

(2018) Murielle G Kluge et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AMPK: Potential Therapeutic Target for Ischemic Stroke

(2018) Shuai Jiang et al.   Theranostics

The oxidation of dehydroascorbic acid and 2,3-diketogulonate by distinct reactive oxygen species

(2018) Rebecca A. Dewhirst et al.   BIOCHEMICAL JOURNAL

Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration

(2017) Murielle G. Kluge et al.   GLIA

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death

(2017) Qiuting Yan et al.   MOLECULAR PHARMACOLOGY

Impact of Metformin on the Severity and Outcomes of Acute Ischemic Stroke in Patients with Type 2 Diabetes Mellitus

(2016) Yohei Mima et al.   Journal of Stroke & Cerebrovascular Diseases

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Embracing Biological and Methodological Variance in a New Approach to Pre-Clinical Stroke Testing

(2016) Thomas A. Kent et al.   Translational Stroke Research

Impact of Metformin on the Severity and Outcomes of Acute Ischemic Stroke in Patients with Type 2 Diabetes Mellitus

(2016) Yohei Mima et al.   Journal of Stroke & Cerebrovascular Diseases

Neuropharmacological Actions of Metformin in Stroke

(2015) Jia Jia et al.   Current Neuropharmacology

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

(2014) Ji Ma et al.   BMC CANCER

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-κB-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

Putative Role of AMPK in Fetal Adaptive Brain Shut-Down: Linking Metabolism and Inflammation in the Brain

(2014) Martin G. Frasch   Frontiers in Neurology

Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

(2010) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enhancement of Learning and Memory by Elevating Brain Magnesium

(2010) Inna Slutsky et al.   NEURON