The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke

Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke

(2020) Masanori Gomi Naito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation

(2020) Xiaoru Duan et al.   Cell Death & Disease

2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury

(2019) Haibo Ni et al.   Frontiers in Neuroscience

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

(2019) Xixi Zhang et al.   Nature Communications

VEGF Signaling in Neurological Disorders

(2018) Joon Shim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

(2018) Yong Ni et al.   NEUROSCIENCE

CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke

(2018) Yuan Qin et al.   ACTA PHARMACOLOGICA SINICA

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

The Structural Basis of Necroptotic Cell Death Signaling

(2018) Emma J. Petrie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective knockout of astrocytic Na+ /H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

(2017) Gulnaz Begum et al.   GLIA

Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

(2017) Beihui Liu et al.   GLIA

Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model

(2017) Pingping Shen et al.   JOURNAL OF NEUROCHEMISTRY

Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury

(2017) Yong-Ming Zhu et al.   NEUROSCIENCE

Overexpression of Mitofusin2 decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation

(2017) Yulong Shi et al.   NEUROSCIENCE LETTERS

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Facilitators and Barriers to Spinal Cord Injury Clinical Trial Participation: Multi-National Perspective of People Living with Spinal Cord Injury

(2016) Kim D. Anderson et al.   JOURNAL OF NEUROTRAUMA

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke

(2016) Li Zhang et al.   STROKE

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway

(2014) Min Xu et al.   GLIA

Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

(2014) Lijie Huang et al.   International Journal of Medical Sciences

Why are Astrocytes Important?

(2014) Alexei Verkhratsky et al.   NEUROCHEMICAL RESEARCH

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Sustained Na+/H+ Exchanger Activation Promotes Gliotransmitter Release from Reactive Hippocampal Astrocytes following Oxygen-Glucose Deprivation

(2014) Pelin Cengiz et al.   PLoS One

Protocol for the Induction of Subarachnoid Hemorrhage in Mice by Perforation of the Circle of Willis with an Endovascular Filament

(2014) Dominik Bühler et al.   Translational Stroke Research

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Factors Influencing the Decline in Stroke Mortality

(2013) Daniel T. Lackland et al.   STROKE

Advanced imaging to extend the therapeutic time window of acute ischemic stroke

(2012) Marc Fisher et al.   ANNALS OF NEUROLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Role of the lesion scar in the response to damage and repair of the central nervous system

(2012) Hitoshi Kawano et al.   CELL AND TISSUE RESEARCH

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

SAR131675, a Potent and Selective VEGFR-3-TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities

(2012) A. Alam et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen-Glucose Deprivation Induced Glial Scar-Like Change in Astrocytes

(2012) Rongrong Wang et al.   PLoS One

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

(2011) Alessandra Valerio et al.   JOURNAL OF NEUROCHEMISTRY

RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression

(2011) Weixiang Guo et al.   NEURON

Neuron tracing in perspective

(2010) Erik Meijering   CYTOMETRY PART A

Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses

(2010) Jong-hyeon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats

(2010) Yoo-Jin Shin et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Necroptosis: A Specialized Pathway of Programmed Necrosis

(2008) Lorenzo Galluzzi et al.   CELL

Intravenous rt-PA versus endovascular therapy for acute ischemic stroke

(2008) Pitchaiah Mandava et al.   Current Atherosclerosis Reports

Extracellular matrix of the central nervous system: from neglect to challenge

(2008) Dieter R. Zimmermann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology