Article
Pharmacology & Pharmacy
Shanshan Gou, Lu Qiu, Qiufang Yang, Peng Li, Xiaowen Zhou, Yixuan Sun, Xiuman Zhou, Wenshan Zhao, Wenjie Zhai, Guodong Li, Yahong Wu, Yonggang Ren, Yuanming Qi, Yiguo Zhang, Yanfeng Gao
Summary: Metformin induces ROS accumulation by inhibiting the expression of the core antioxidant transcription factor NFE2L1, which can be reversed by high glucose. The inhibitory effect of metformin on NFE2L1 is AMPK-independent, and NFE2L1 may play a crucial role in regulating the AMPK signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Article
Cell Biology
Hong-Yue Lai, Hsin-Hwa Tsai, Chia-Jui Yen, Liang-Yi Hung, Ching-Chieh Yang, Chung-Han Ho, Hsin-Yin Liang, Feng-Wei Chen, Chien-Feng Li, Ju-Ming Wang
Summary: This study found that HCC patients receiving sorafenib with HBV were at higher risk of mortality, and high EGFR expression was linked to HBV-induced sorafenib resistance. Additionally, AMPK/CEBPD-activated autophagy could be a potent strategy for improving the efficacy of sorafenib in HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hong-Yue Lai, Hsin-Hwa Tsai, Chia-Jui Yen, Liang-Yi Hung, Ching-Chieh Yang, Chung-Han Ho, Hsin-Yin Liang, Feng-Wei Chen, Chien-Feng Li, Ju-Ming Wang
Summary: Activation of autophagy can both promote survival of residual cancer cells and lead to cell death, with implications for sorafenib resistance in hepatocellular carcinoma patients. High EGFR expression is linked to HBV-induced sorafenib resistance, with AMPK/CEBPD-activated autophagy presenting a potential strategy for enhancing sorafenib efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Mengmeng Chen, Yushan Fu, Xu Wang, Ruitong Wu, Dongmei Su, Nan Zhou, Yanhua Qi
Summary: The senescence of lens epithelial cells (LECs) is a major factor leading to age-related cataract (ARC). This study aimed to investigate the mechanism of ARC formation and explore the anti-aging effect of metformin (MET) on ARC. The results showed that MET effectively alleviated the senescence of LECs and the formation of ARC probably through inactivation of the AMPK pathway and augmentation of autophagy.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Jelka Hartwig, Madlen Loebel, Sophie Steiner, Sandra Bauer, Zehra Karadeniz, Carsten Roeger, Carsten Skurk, Carmen Scheibenbogen, Franziska Sotzny
Summary: The study showed that metformin can reduce ROS/RNS levels in immune cells by activating FOXO3. This may contribute to the beneficial clinical effects of metformin on longevity, cardiovascular health, and cancer risk.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chong Xu, Sujuan Chen, Ming Xu, Xiaoling Chen, Xiaoxue Wang, Hai Zhang, Xiaoqing Dong, Ruijie Zhang, Xin Chen, Wei Gao, Shile Huang, Long Chen
Summary: Cadmium induces autophagosome expansion and neuronal apoptosis by activating the JNK pathway. This study highlights the potential therapeutic intervention of manipulating intracellular calcium levels and JNK activity to ameliorate Cd-induced neurotoxicity and neurodegeneration.
NEUROCHEMICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Wei Mu, Yunyun Jiang, Guoqiang Liang, Yue Feng, Falin Qu
Summary: Metformin is a commonly used drug for patients with type 2 diabetes mellitus. It works by inhibiting hepatic gluconeogenesis and increasing glucose utilization in peripheral tissues. Recent studies have shown that metformin has potential as an anticancer agent, either alone or in combination with other treatments. It activates the AMPK complex and regulates intracellular energy status, inhibiting mitochondrial respiratory chain complex I and reducing reactive oxygen species production.
CURRENT DRUG TARGETS
(2023)
Article
Nanoscience & Nanotechnology
Jing Li, Ziyi Zhu, Lizi Ye, Zhiyang Wang, Guangda Xiang, Shuguang Li, Ling Yue
Summary: Metformin increases ROS accumulation and induces apoptosis in PTC cells by inhibiting Nrf2 expression. The AMPK/mTOR signaling pathway partially participates in the apoptosis process.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Immunology
Qilin Feng, Ke Hu, Huifang Hu, Yumeng Lu, Hui Zhang, Guanli Wang, Qikai Zhang, Zhijian Xu, Xuejie Gao, Xinyan Jia, Huabin Zhu, Dongliang Song, Hongfei Yi, Yu Peng, Xiaosong Wu, Bo Li, Weiliang Zhu, Jumei Shi
Summary: The study found that DCZ0358 can inhibit the proliferation of DLBCL cells and block the cell cycle progression at the G0/G1 phase. In addition, DCZ0358 also caused mitochondrial dysfunction, cell apoptosis, DNA damage, and activated the ROS/JNK pathway. The combination of DCZ0358 and etoposide also showed synergistic anti-tumor effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaoling Chen, Xiaoxue Wang, Liu Yang, Hongjiang Xu, Yiqun Wu, Jialin Wu, Long Chen, Chong Xu
Summary: This study investigated the protective effect of magnesium isoglycyrrhizinate (MgIG) on cadmium-induced hepatotoxicity, revealing that MgIG attenuated apoptotic cascade induced by Cd by blocking the JNK pathway. Mechanistically, MgIG rescued Cd-inactivated PP2A, which prevented JNK activation and hepatocyte apoptosis. Additionally, MgIG blocked Cd-induced ROS generation, reinforcing its protective effects.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, Jose Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli, Natasha Irrera
Summary: The present study evaluated the effects of beta-Caryophyllene (BCP) on Cd-induced neurotoxicity. The results showed that BCP treatment reduced ROS production, increased Nrf2 expression, and protected cells from death. BCP also regulated the apoptosis pathway and reduced the increase of pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Guangli Lu, Zhen Wu, Jia Shang, Zhenxing Xie, Chaoran Chen, Chuning Zhang
Summary: Metformin is the first-line option for treating diabetic patients and has various pharmacological actions, including antitumor, anti-aging, and ovarian protection effects. Recent research has shown that autophagy is a crucial mechanism through which metformin exerts its pharmacological actions, although the effects on autophagy remain inconsistent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Cheol Park, Seon Yeong Ji, Hyesook Lee, Sung Hyun Choi, Chan-Young Kwon, So Young Kim, Eun Tag Lee, Sung Tae Choo, Gi-Young Kim, Yung Hyun Choi, Mi Ryeo Kim
Summary: The study found that the aqueous extracts of Mori Ramulus (AEMR) have a protective effect against oxidative stress caused by hydrogen peroxide (H2O2) by maintaining mitochondrial function and activating the AMPK signaling pathway. Oral administration of AEMR also alleviated muscle atrophy induced by dexamethasone (DEX).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Ye Han, Qingsong Yu, Xiaoqing Dong, Jianxia Hou, Jianmin Han
Summary: SiOx:H nanocoatings prepared using plasma deposition technique exhibit excellent antibacterial and anti-inflammatory properties, reducing bacterial growth, biofilm formation, and inflammatory response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cell Biology
Ruijie Zhang, Chunxiao Liu, Liu Yang, Tong Ji, Nana Zhang, Xiaoqing Dong, Xin Chen, Jing Ma, Wei Gao, Shile Huang, Long Chen
Summary: Research shows that PD toxins induce neuronal apoptosis by generating H2O2 through NOX2, hindering the AMPK/Akt-mTOR signaling pathway. Inhibiting NOX2 or using antioxidants may help alleviate neuronal loss caused by oxidative stress.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Qiaoyan Han, Hua Bai, Yong Xu, Min Zhou, He Zhou, Xiaoqing Dong, Bing Chen
Summary: The study demonstrates that solamargine (SM) exhibits promising anti-multiple myeloma (MM) activity by suppressing MM cell viability through activating cell autophagy and inducing apoptosis. Additionally, a synergistic effect between SM and the common chemotherapeutic agent bortezomib (BTZ) is observed, suggesting a potential therapeutic strategy for treating MM.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Tong-Mou Geng, Kang Wang, Xue-Hua Zhou, Xiao-Qing Dong
Summary: A new bipyrazole-based porous organic polymer TMBPH, constructed by nucleophilic substitution polymerization reaction, exhibits high iodine adsorption capacity and fluorescence sensing properties.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Microbiology
Kul Raj Rai, Yuan Liao, Mengjuan Cai, Haori Qiu, Faxin Wen, Min Peng, Song Wang, Shasha Liu, Guijie Guo, Xiaojuan Chi, Mohamed Maarouf, Yuhai Chen, Shile Huang, Ji-Long Chen
Summary: In this study, lncRNA-155KO mice lacking most of the lncRNA-155 sequences were found to be more susceptible to influenza virus or pseudorabies virus infection compared to miRNA-155KO mice. The loss of lncRNA-155 resulted in faster body weight loss, poorer survival, and higher viral load. The findings suggest the involvement of lncRNA-155 in regulating viral pathogenesis in addition to miRNA-155. miRNA-155-deleted lncRNA-155 significantly attenuated the viral infection.
Article
Biochemistry & Molecular Biology
Peiqing Guan, Chunzheng Huang, Qinghui Lan, Shile Huang, Peiling Zhou, Changzheng Zhang
Summary: This study investigated the relationship between post-traumatic stress disorder (PTSD) and ventral tegmental area (VTA) dopaminergic signaling. By activating VTA dopamine neurons, the researchers found that anxiety-like behaviors in a PTSD model were mitigated. These findings suggest that enhancing VTA dopaminergic activity may be a potential strategy for treating PTSD.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Immunology
Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane-Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu
Summary: Fisetin has potential therapeutic effects on refractory psoriasis by inhibiting abnormal immune response, promoting keratinocyte differentiation and autophagy, and reducing disease inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Neurosciences
Qianyun Yu, Ruijie Zhang, Tianjing Li, Liu Yang, Zhihan Zhou, Long Hou, Wen Wu, Rui Zhao, Xiaoling Chen, Yajie Yao, Shile Huang, Long Chen
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Qianyun Yu, Ruijie Zhang, Tianjing Li, Liu Yang, Zhihan Zhou, Long Hou, Wen Wu, Rui Zhao, Xiaoling Chen, Yajie Yao, Shile Huang, Long Chen
Summary: Defective autophagy is involved in the development of Parkinson's disease (PD), and PD toxins impede autophagy through the PTEN/Akt signaling pathway, leading to neuronal apoptosis. Activation of PTEN and inactivation of Akt by PD toxins inhibit autophagy, and this process is regulated by the protein Parkin. Manipulation of PTEN/Akt/autophagy signaling with antioxidants could be a potential therapeutic strategy for preventing neuronal loss in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Terry C. Lairmore, Jehan Abdulsattar, Arrigo De Benedetti, Runhua Shi, Shile Huang, Md Imtiaz Khalil, Stephan N. Witt
Summary: Immunohistochemical analysis showed an inverse association between menin expression and tumor grade in cholangiocarcinoma. Menin expression was higher in low-grade tumors and lower in high-grade tumors. Menin expression was also positively associated with fibrosis status.
BMC RESEARCH NOTES
(2023)
Article
Biochemistry & Molecular Biology
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Guie Chen, Yanqin Lai, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Summary: Rabies is a highly fatal zoonotic disease with no effective treatment available. Recent studies have shown that the tripartite-motif protein (TRIM) family plays a role in regulating viral replication. Specifically, tripartite-motif protein 21 (TRIM21) has been found to be upregulated in the brain tissue of mice infected with rabies virus and its knockdown inhibits viral replication. Knockdown of interferon-alpha and interferon-beta further modulates the inhibition of viral replication caused by TRIM21 knockdown. TRIM21 regulates RABV replication via the IRF7-IFN axis, highlighting its potential as a target for rabies treatment or management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Genetics & Heredity
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Summary: TRIM25 plays a crucial role in the infection of rabies virus, regulating its replication through the RIG-I-IFN axis. This finding suggests that TRIM25 may serve as a potential target for the development of antiviral drugs against rabies.
Article
Chemistry, Multidisciplinary
Yu Wang, Rao Chen, Dongmei Liu, Chaofei Peng, Junwei Wang, Xiaoqing Dong
Summary: This study designed and synthesized a series of new functionalized photoinitiators containing thioxanthones and oxime-esters as functional groups. The photophysical properties of the photoinitiators were investigated and the thioxanthone derivatives showed long wavelength absorptions from 360 nm to 405 nm, making them suitable for UV-Vis LED light sources. The structure-reactivity relationship was studied in detail using real-time FTIR spectroscopy, and a possible photolysis mechanism was predicted. The new functionalized photoinitiators displayed more advanced initiation abilities than their parent thioxanthone.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Hematology
Ping Chen, Sungui Wu, Xiaoqing Dong, Min Zhou, Peipei Xu, Bing Chen
Summary: The Chinese medicine monomer formosanin C (FC) exhibits an anti-multiple myeloma (MM) effect by suppressing cell viability and colony formation, while promoting autophagy and apoptosis in MM cells. These effects are mediated through activation of the PI3K/AKT/mTOR signaling pathway.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.