Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Mehwish S. Bhatti, Ron D. Frostig
Summary: We have shown that sensory stimulation can protect against impending cortical ischemic stroke in a rat model. The activation of collaterals that allow for reperfusion of the ischemic area is a major mechanism underlying this protection. Additionally, we have found that the activation of astrocyte-neuron lactate shuttle (ANLS) is another important mechanism that complements collateral flow in the protection process.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Jixian Wang, Guofeng Li, Lidong Deng, Muyassar Mamtilahun, Lu Jiang, Weibao Qiu, Hairong Zheng, Junfeng Sun, Qing Xie, Guo-Yuan Yang
Summary: Transcranial focused ultrasound stimulation (tFUS) can promote neurorehabilitation after brain ischemia by promoting microglia polarization and further regulating IL-10 signaling in the ischemic brain.
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Fabio Pilato, Giovanni Pellegrino, Rosalinda Calandrelli, Aldobrando Broccolini, Giacomo Della Marca, Giovanni Frisullo, Roberta Morosetti, Paolo Profice, Valerio Brunetti, Fioravante Capone, Gabriella D'Apolito, Vincenzo Quinci, Alessio Albanese, Annunziato Mangiola, Enrico Marchese, Angelo Pompucci, Vincenzo Di Lazzaro
Summary: This study analyzed baseline characteristics and factors linked to therapeutic choice and determinants of prognosis in patients with mMCA undergoing DHC or BMT. The study found that DHC reduces mortality during admission, but may result in long-term disability.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
N. Boulenoir, G. Turc, H. Henon, N. Laksiri, F. Mounier-Vehier, I. Girard Buttaz, D. -L. Duong, J. Papassin, M. Yger, A. Triquenot, A. Lyoubi, A. Ter Schiphorst, C. Denier, J. -C. Baron, P. Seners
Summary: Understanding the incidence, predictors, and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may help guide therapeutic decisions. The location of internal carotid artery occlusion is strongly associated with END, suggesting a different response to IVT. These findings indicate that END may be preventable in this setting.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Johannes Goldberg, Peter Vajkoczy, Nils Hecht
Summary: Using indocyanine green videoangiography (ICG-VA) can facilitate identification of potential recipient vessels and detection of pathological flow patterns. Recipients with initially low flow, late appearance, and retrograde flow direction appear to have the highest potential for flow increase.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Michael Bieber, Michael K. Schuhmann, Maximilian Bellut, David Stegner, Katrin G. Heinze, Mirko Pham, Bernhard Nieswandt, Guido Stoll
Summary: This study demonstrates that combining neuroprotective and anti-platelet interventions can enhance therapeutic effects in patients with ischemic stroke, providing new insights for the clinical treatment of hyper-acute stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jiajia Wang, Shiquan Wang, Haiyun Guo, Yi Li, Zhenhua Jiang, Ting Gu, Binxiao Su, Wugang Hou, Haixing Zhong, Dandan Cheng, Xijing Zhang, Zongping Fang
Summary: The study demonstrated that rosmarinic acid (RA) treatment significantly improved neurological and depressive symptoms after stroke, and reduced brain infarct volume. RA exerted its protective effects against ischemia by enhancing the activities of antioxidant enzymes and glutathione levels. Additionally, RA alleviated depression behaviors through Nrf2-mediated pathways.
Article
Neurosciences
Huiyuan Wang, Panpan Shen, Xinyue Yu, Yafei Shang, Jie Xu, Xinyi Chen, Mingming Tan, Longting Lin, Mark Parsons, Sheng Zhang, Yu Geng
Summary: The study aimed to investigate the relationship between asymmetric deep cerebral venous (ADCV) filling and poor outcomes after endovascular treatment (EVT) in patients with acute basilar artery occlusion (ABAO). The results showed that preoperative ADCV filling is an independent influencing factor for the poor outcome after EVT in ABAO patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chiara Di Santo, Daniele La Russa, Rosaria Greco, Alessandra Persico, Anna Maria Zanaboni, Giacinto Bagetta, Diana Amantea
Summary: The identification of novel targets to modulate the immune response triggered by cerebral ischemia is crucial for stroke therapeutics. This study revealed the involvement of tumour necrosis factor (TNF)-alpha-stimulated gene 6 (TSG-6) in regulating immune and stromal cell functions in acute neurodegeneration caused by ischemic stroke. The elevated levels of TSG-6 in the brain and peripheral blood indicate its potential detrimental role in the early reperfusion stage, while providing protection against brain infarct volume and neurological deficits when administered acutely. These findings highlight the important role of TSG-6 in ischemic stroke pathobiology and warrant further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Rytis Jurkonis, Monika Makunaite, Mindaugas Baranauskas, Arunas Lukosevicius, Andrius Sakalauskas, Vaidas Matijosaitis, Daiva Rastenyte
Article
Medicine, General & Internal
Mindaugas Baranauskas, Rytis Jurkonis, Arunas Lukosevicius, Monika Makunaite, Vaidas Matijosaitis, Rymante Gleizniene, Daiva Rastenyte
Article
Medicine, General & Internal
Daiva Rastenyte, Vaidas Matijosaitis, Ovidijus Laucius, Rymante Gleizniene, Simonas Jesmanas, Kristina Jureniene
Article
Neurosciences
Fumiaki Ikawa, Shigeru Tanaka, Kana Harada, Izumi Hide, Hirofumi Maruyama, Norio Sakai
Summary: The study found that GPR3 is widely distributed in the nervous system, expressed in regions related to various functions, frequently co-expressed with NECAB2 in specific neurons, and may modulate Ca2+ signaling by interacting with NECAB2.
Article
Neurosciences
Saulius Taroza, Daiva Rastenyte, Julius Burkauskas, Aurelija Podlipskyte, Nijole Kazukauskiene, Vaiva Patamsyte, Narseta Mickuviene
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Medicine, General & Internal
Mindaugas Baranauskas, Rytis Jurkonis, Arunas Lukosevicius, Vaidas Matijosaitis, Rymante Gleizniene, Daiva Rastenyte
Article
Neurosciences
Shigeru Tanaka, Naoto Shimada, Hiroko Shiraki, Tatsuhiro Miyagi, Kana Harada, Izumi Hide, Norio Sakai
Summary: During neuronal development, GPR3 plays a crucial role in neurite outgrowth and neuronal differentiation by mediating multiple signaling pathways including PKA, ERKs, and PI3K. Additionally, GPR3 activation accelerates polarity formation by influencing downstream signaling pathways such as Akt and GRK2, ultimately promoting neurite outgrowth and polarity establishment in differentiated neurons.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Simonas Jesmanas, Rymante Gleizniene, Mindaugas Baranauskas, Vaidas Matijosaitis, Daiva Rastenyte
Summary: This study aimed to evaluate the associations between impaired olfactory performance and regional gray matter atrophy in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and healthy elderly individuals. The results showed that in AD patients, there was a correlation between odor identification performance and atrophy of the orbitofrontal cortex, while no significant correlations were found in PD patients and healthy elderly individuals.
Article
Pharmacology & Pharmacy
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai
Summary: GPR3 is immediately induced by T cell stimulation and plays an important role in suppressing effector T cell activation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai
Summary: The expression of GPR3 in retinal ganglion cells (RGCs) plays an important role in axonal regeneration and neuronal survival. Knocking out the GPR3 gene makes RGCs more vulnerable to neural death, while upregulation of GPR3 accelerates axonal regeneration.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Medicine, General & Internal
Ieva Navickaite, Migle Alisauskiene, Sandra Petrauskiene, Gintare Zemgulyte
Summary: This article presents a clinical case of sarcoidosis-associated ganglionopathy and Harlequin syndrome, highlighting the importance of considering an autoimmune etiology for these disorders.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Sandra Petrauskiene, Dominika Kopczynska, Gintare Zemgulyte, Kristina Saldunaite-Mikucioniene
Summary: The aim of this study was to evaluate the knowledge of oral cancer risk factors among international medical and dental students at LSMU. A total of 253 students participated, with a response rate of 76.2%. The results showed that 15.02%, 56.92%, and 28.06% of the participants had good, fair, and poor knowledge of oral cancer risk factors, respectively. The mean score for knowledge was 10.01 (SD = 2.56), indicating fair knowledge.