Article
Biochemistry & Molecular Biology
Berenice Le Dieu-Lugon, Nicolas Dupre, Celine Derambure, Francois Janin, Bruno J. Gonzalez, Stephane Marret, Arnaud Arabo, Philippe Leroux
Summary: MgSO4 is widely used in preventing neurological disabilities in preterm infants, mainly by suppressing synaptogenesis and axonal development to reduce inflammation and innate immune responses. Additionally, MgSO4 affects neural development by inhibiting RNA polymerase II transcription and regulating mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Neurosciences
L. E. Duran-Carabali, F. K. Odorcyk, E. F. Sanches, M. M. de Mattos, F. Anschau, C. A. Netto
Summary: Neonatal hypoxia-ischemia (HI) is a major cause of mortality and morbidity in newborns, and there is currently no definitive treatment for this condition. This study conducted a systematic review and meta-analysis of articles on environmental enrichment (EE) in HI rodent models. The results showed that EE had a beneficial impact on neurodevelopmental reflexes, motor and cognitive function, as well as brain damage. Factors such as study quality, age at injury, and duration of EE exposure influenced the positive effects of EE. Overall, EE showed promise as a therapeutic strategy for HI.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Lei Lei, Biran Zhu, Kun Qiao, Yuxi Zhou, Xiangping Chen, Jun Men, Lihua Yang, Qidong Wang, Jian Han, Bingsheng Zhou
Summary: This study investigated the neurobehavioral changes in adult zebrafish exposed to environmentally relevant levels of deltamethrin, a widely used insecticide. The results showed that deltamethrin exposure increased swimming speeds, residence time near other fish, and shoaling cohesion in zebrafish. Transcriptomic analysis revealed disruptions in neural functions related to glutamatergic and dopaminergic synapses in the brain. The measurement of neurotransmitters confirmed an increase in glutamate content. These findings suggest that deltamethrin exposure can lead to hyperactivity of social behaviors in adult zebrafish by increasing glutamate levels and promoting its release.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Clinical Neurology
D'bora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rubensam, Robert Gerlai, Carla Denise Bonan
Summary: This study investigated the effects of the dopamine D2/D3 receptor agonist quinpirole on the behavior, brain-derived neurotrophic factor (BDNF), and neurotransmitter levels in adult zebrafish. The results showed that quinpirole administration caused decreased locomotor activity, increased anxiety-like behaviors, memory impairment, and stereotypic swimming in zebrafish. Furthermore, quinpirole treatment also decreased the number of BDNF-immunoreactive cells and altered glutamate and serotonin levels in the zebrafish brain. These findings suggest that quinpirole administration in adult zebrafish can be a useful tool for studying the mechanisms underlying neurological disorders related to the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Serhat Imamoglu, Ebru Yalin Imamoglu, Serkan Erdenoz, Alev Cumbul, Unal Uslu, Samil AktaS, Fahri Ovali
Summary: The study showed that magnesium sulfate could reduce apoptosis, preserve RGCs, and decrease retinal VEGFR-2 and GFAP expressions in a preterm hypoxic-ischemic rat model.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Chia-Chan Wu, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang
Summary: Eupatilin can inhibit glutamate release from neuronal synaptosomes through various mechanisms and prevent excitotoxic damage in an animal model, indicating its potential therapeutic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yun-Zhi Zhao, Jun Wei, Ke-Xin Song, Chen Zhou, Zhen Chai
Summary: The present study found that non-hibernating Daurian ground squirrel (GS) neurons were more resistant to oxygen-glucose deprivation (OGD) compared to rat neurons. Glutamate-aspartate transporter 1 (GLAST) was identified as a cytoprotective factor that contributed to the tolerance against OGD injury in GS neurons. Overexpression of GLAST rescued viability in rat neurons, while knockdown of GLAST led to decreased viability in GS neurons. This study revealed a molecular mechanism underlying the survival of hibernating mammals and suggested GLAST as a potential target for ischemic stroke therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
B. Haridevamuthu, David Raj, D. Kesavan, Subramani Muthuraman, Rajendran Saravana Kumar, Shahid Mahboob, Khalid Abdullah Al-Ghanim, Bader O. Almutairi, Selvaraj Arokiyaraj, Pushparathinam Gopinath, Jesu Arockiaraj
Summary: The present study investigates the antioxidant role of trihydroxy piperlongumine (THPL) against aluminum (Al)-induced neurotoxicity in zebrafish. THPL reduces oxidative damage in the brain by quenching Al-induced free radicals and lipid peroxidation. THPL also improves behavior deficits and anxiety-like phenotype in zebrafish, suggesting its potential as a psychopharmacological drug.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Si Han Li, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson
Summary: Glutamate, the primary excitatory neurotransmitter in the brain, plays crucial roles in neuronal function. mGluR2 and mGluR3, members of the Group II mGluR family, have been implicated in the pathophysiology of various neurodegenerative and neuropsychiatric diseases, making them potential drug targets for treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinska
Summary: This study found that activation of group II mGlu receptors can prevent brain damage and regulate apoptosis and neuroprotective mechanisms in experimental birth asphyxia. Agonists LY379268 and NAAG can inhibit excessive glutamate release and apoptotic damage, and restore the concentration of neurotrophins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Helene Roumes, Stephane Sanchez, Imad Benkhaled, Valentin Fernandez, Pierre Goudeneche, Flavie Perrin, Luc Pellerin, Jerome Guillard, Anne-Karine Bouzier-Sore
Summary: Polyphenols extracted in an eco-sustainable manner have neuroprotective effects and can prevent brain lesions and associated deficits in a rat model of neonatal hypoxia-ischemia.
Article
Medicine, General & Internal
Andres Da Silva-Candal, Antonio Dopico-Lopez, Maria Perez-Mato, Manuel Rodriguez-Yanez, Jose M. Pumar, Paulo Avila-Gomez, Jose Castillo, Tomas Sobrino, Francisco Campos, Pablo Hervella, Ramon Iglesias-Rey
Summary: The study showed that ischemic stroke patients with early onset had higher serum glutamate levels and lower IL-6 levels, with a glutamate/IL-6 index serving as an early identification tool for stroke onset.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Review
Anesthesiology
Kyung-Cheon Lee, Il-Ok Lee
Summary: Preoperative laboratory testing in elderly patients can predict postoperative complications, enabling the initiation of a care plan.
CURRENT OPINION IN ANESTHESIOLOGY
(2021)
Article
Medicine, General & Internal
Young Sung Kim, Hae Wone Chang, Heezoo Kim, Jong Sun Park, Young Ju Won
Summary: A study comparing the use of dexmedetomidine and remifentanil in inducing general anesthesia for patients undergoing laryngeal microsurgery found that dexmedetomidine reduced postoperative opioid use and sore throat incidence, although it resulted in a transient delay in emergence time.
Review
Anesthesiology
Seok Kyeong Oh, Byung Gun Lim, Young Ju Won, Dong Kyu Lee, Seong Shin Kim
Summary: Erector spinae plane block (ESPB) can improve postoperative analgesia, reduce opioid consumption, increase patient satisfaction, and decrease postoperative nausea and vomiting in patients undergoing lumbar surgery. However, there is considerable heterogeneity and low-quality evidence in the studies.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Neurosciences
Young Sung Kim, Sung-Hwa Sohn, Too Jae Min
Summary: This study demonstrates that Ulinastatin can improve learning and memory impairments caused by hypoxia in zebrafish in a dose-dependent manner, with higher doses showing better effects.
NEUROMOLECULAR MEDICINE
(2023)
Article
Anesthesiology
Chung Hun Lee, Soo Ah Cho, Seok Kyeong Oh, Sang Sik Choi, Myoung Hoon Kong, Young Sung Kim
Summary: This study demonstrates the usefulness of a dual chamber IV-PCA system that adjusts infusion rate based on pain feedback. The use of the dual-channel elastomeric infusion pump resulted in decreased fentanyl consumption, reduced need for rescue analgesics, improved patient satisfaction, and increased incidence of postoperative nausea and vomiting.
BMC ANESTHESIOLOGY
(2022)
Article
Anesthesiology
MiHye Park, Susie Yoon, Jae-Sik Nam, Hyun Joo Ahn, Heezoo Kim, Hye Jin Kim, Hoon Choi, Hong Kwan Kim, Randal S. Blank, Sung-Cheol Yun, Dong Kyu Lee, Mikyung Yang, Jie Ae Kim, Insun Song, Bo Rim Kim, Jae-Hyon Bahk, Juyoun Kim, Sangho Lee, In-Cheol Choi, Young Jun Oh, Wonjung Hwang, Byung Gun Lim, Burn Young Heo
Summary: Driving pressure-guided ventilation improves intraoperative pulmonary mechanics, but does not reduce the incidence of postoperative pulmonary complications in lung resection surgery.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Seok-Kyeong Oh, Byung-Gun Lim
MINERVA ANESTESIOLOGICA
(2023)
Article
Anesthesiology
Seok Kyeong Oh, Byung Gun Lim, Heezoo Kim, Jae Hak Lee, Jae Eun Lee
Summary: Adding a wrist brace can improve the accuracy of acceleromyography (AMG), especially in the prone position.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Young Ju Won, Seok Kyeong Oh, Byung Gun Lim, Young Sung Kim, Do Yeop Lee, Jae Hak Lee
Summary: In elderly patients, SPI-guided analgesia provides appropriate analgesia with sufficient remifentanil consumption, lower incidence of hypertension/tachycardia events, and a lower incidence of delirium in the PACU than conventional analgesia. However, SPI-guided analgesia may not prevent perioperative immune system deterioration.
BMC ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Hyo Sung Kim, Young Sung Kim, Byung Gun Lim, Jae Hak Lee, Jihyun Song, Heezoo Kim
Summary: This study validated the predictive power of the COLDS score as a risk assessment tool for children with URTI undergoing elective surgery under general anesthesia. The study found that age, current symptoms, and COLDS score were significant variables in predicting PRAEs. In addition to a higher COLDS score, younger age and current URTI symptoms were also significant risk factors for PRAEs.
MEDICINA-LITHUANIA
(2022)
Article
Surgery
Shin-Hoo Park, Hyub Huh, Sung Il Choi, Jong-Han Kim, You-Jin Jang, Joong-Min Park, Oh Kyoung Kwon, Mi Ran Jung, Oh Jeong, Chang Min Lee, Jae Seok Min, Jin-Jo Kim, Liang An, Kyung Sook Yang, Sungsoo Park, Il Ok Lee
Summary: Deep neuromuscular block improves laparoscopic surgical conditions and enables retrieval of more lymph nodes during laparoscopic gastrectomy in obese patients.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Review
Medicine, General & Internal
Young-Sung Kim, Byung-Gun Lim, Young-Ju Won, Seok-Kyeong Oh, Jung-Suk Oh, Soo-Ah Cho
Summary: Through a systematic review, it was found that the efficacy and safety of using Sugammadex to reverse rocuronium-induced NMB in ESRD patients are good, although the recovery to a TOF ratio of 0.9 may take longer. However, further studies are needed due to the limited number of studies and high heterogeneity in some of the results.
MEDICINA-LITHUANIA
(2021)
Article
Anesthesiology
Young Sung Kim, Chung Hun Lee, Ah Rahn Kim, Sang Sik Choi, Mi Kyoung Lee, Heezoo Kim, Seok Kyeong Oh
Summary: The study aimed to confirm the microbiological and physicochemical stability of various intravenous patient-controlled analgesia drug mixtures. The results showed that, except for ketorolac, the drugs were physicochemically stable up to 96 hours after mixing.
Article
Medicine, General & Internal
Hae Wone Chang, Il Ok Lee, Hyoseok Kang, Young Ju Won, Young-seob Lim
Summary: Sugammadex at a dosage of 4 mg/kg was found to prolong coagulation time in surgical patients, potentially enhancing postoperative hypocoagulation without affecting other thromboelastography parameters.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)