An Aicardi-Goutières Syndrome–Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice

Systemic inflammation and chronic kidney disease in a patient due to the RNASEH2B defect

(2021) Tingyan He et al.   Pediatric Rheumatology

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

Type I Interferonopathies in Children: An Overview

(2021) Debora M. d'Angelo et al.   Frontiers in Pediatrics

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

(2021) Xinfeng Guo et al.   Journal of Neuroinflammation

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

(2020) Claudio Lo Giudice et al.   Nature Protocols

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

(2020) Pedro Henrique Costa Cruz et al.   RNA

ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

(2020) Tuangtong Vongpipatana et al.   JOURNAL OF IMMUNOLOGY

Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome

(2020) Shaoling Zheng et al.   Frontiers in Immunology

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs

(2020) Jacki E. Heraud-Farlow et al.   Open Biology

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function

(2019) Nelli Baal et al.   JOURNAL OF IMMUNOLOGY

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADAR

(2019) Alan Herbert   EUROPEAN JOURNAL OF HUMAN GENETICS

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

Cardiac valve involvement in ADAR-related type I interferonopathy

(2019) Yanick Crow et al.   JOURNAL OF MEDICAL GENETICS

Astrocytes, an active player in Aicardi-Goutières syndrome

(2018) Sunetra Sase et al.   BRAIN PATHOLOGY

Variable clinical phenotype in two siblings with Aicardi-Goutières syndrome type 6 and a novel mutation in the ADAR gene

(2018) Lisa Schmelzer et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

(2018) Taisuke Nakahama et al.   EMBO REPORTS

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq

(2017) Peng Hu et al.   MOLECULAR CELL

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

(2017) Brian S Johnson et al.   NATURE MEDICINE

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

(2016) Karen J Mackenzie et al.   EMBO JOURNAL

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

(2016) Vladislav Pokatayev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Bilateral striatal necrosis in two subjects with Aicardi-Goutières syndrome due to mutations inADAR1(AGS6)

(2013) Roberta La Piana et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi–Goutières syndrome

(2013) Eloy Cuadrado et al.   BRAIN

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

A type I interferon signature identifies bilateral striatal necrosis due to mutations inADAR1

(2013) John H Livingston et al.   JOURNAL OF MEDICAL GENETICS

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

(2012) Zhiyu Peng et al.   NATURE BIOTECHNOLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Darned in 2013: inclusion of model organisms and linking with Wikipedia

(2012) Anmol M. Kiran et al.   NUCLEIC ACIDS RESEARCH

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aicardi–Goutières syndrome presenting atypically as a sub-acute leukoencephalopathy

(2008) S. Orcesi et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in aicardi-Goutières syndrome

(2008) Jane T. Van Heteren et al.   GLIA

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon

(2008) Cyril X. George et al.   VIROLOGY