Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

(2017) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways

(2017) Lisa P. Daley-Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

(2017) Heather Koehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

(2017) Boris M. Hartmann et al.   Nature Communications

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

(2016) Deli Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

(2016) Xiaoliang Yu et al.   Virology Journal

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of apoptosis and necroptosis signaling by herpesviruses

(2015) Hongyan Guo et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

True Grit: Programmed Necrosis in Antiviral Host Defense, Inflammation, and Immunogenicity

(2014) E. S. Mocarski et al.   JOURNAL OF IMMUNOLOGY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1

(2013) T. H. Pham et al.   JOURNAL OF VIROLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Solution structure of the Z  domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs

(2011) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Viral strategies for the evasion of immunogenic cell death

(2010) L. Galluzzi et al.   JOURNAL OF INTERNAL MEDICINE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA

(2008) S. C. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA