Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis

(2022) Zhanke He et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ferroptosis is Involved in Hypoxic-ischemic Brain Damage in Neonatal Rats

(2022) Wei Lin et al.   NEUROSCIENCE

Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway

(2022) Kaiyi Zhu et al.   Oxidative Medicine and Cellular Longevity

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Ferroptosis in infection, inflammation, and immunity

(2021) Xin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2

(2021) Eamon Fitzgerald et al.   Scientific Reports

NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats

(2021) Lauren E. Adams et al.   Antioxidants

Do levels of lipid peroxidation biomarkers reflect the degree of brain injury in newborns?

(2021) Mari Merce Cascant-Vilaplana et al.   ANTIOXIDANTS & REDOX SIGNALING

NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes

(2021) Dorothea D Jenkins et al.   Antioxidants

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats

(2021) Kaiyi Zhu et al.   EXPERIMENTAL NEUROLOGY

Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

(2021) Min Hu et al.   MOLECULAR HUMAN REPRODUCTION

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

The Potential Value of Targeting Ferroptosis in Early Brain Injury After Acute CNS Disease

(2020) Junhui Chen et al.   Frontiers in Molecular Neuroscience

Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway

(2020) Zhixian Gou et al.   BRAIN RESEARCH BULLETIN

Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants

(2020) Quynh Do et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

The Potential Role of Ferroptosis in Neonatal Brain Injury

(2019) Yanan Wu et al.   Frontiers in Neuroscience

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Sex differences in neonatal mouse brain injury after hypoxia‐ischemia and adaptaquin treatment

(2019) Kenan Li et al.   JOURNAL OF NEUROCHEMISTRY

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia

(2019) Yanyan Sun et al.   Frontiers in Cellular Neuroscience

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Coenzyme Q10 Supplementation in Aging and Disease

(2018) Juan D. Hernández-Camacho et al.   Frontiers in Physiology

CoQ10 a super-vitamin: review on application and biosynthesis

(2018) Shraddha Shukla et al.   3 Biotech

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

CoQ10 a super-vitamin: review on application and biosynthesis

(2018) Shraddha Shukla et al.   3 Biotech

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats

(2018) Xiaodi Chen et al.   EXPERIMENTAL NEUROLOGY

Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia–ischemia

(2018) Juan Rodriguez et al.   Cell Death & Disease

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis

(2017) Jonathan A. Stefely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats

(2017) Mingchu Fang et al.   Oncotarget

CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues

(2017) Sarah A. Abd El-Aal et al.   Frontiers in Pharmacology

Coenzyme Q biosynthesis and its role in the respiratory chain structure

(2016) María Alcázar-Fabra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Coenzyme Q biosynthesis in health and disease

(2016) Manuel Jesús Acosta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Intravenous Treatment With Coenzyme Q10 Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Brain Ischemia in Rats

(2016) Margarita Belousova et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Lipid peroxides in the serum of asphyxiated neonates

(2016) N Ramy et al.   Journal of Perinatology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

New horizons for newborn brain protection: enhancing endogenous neuroprotection

(2015) K Jane Hassell et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Protective Effects ofN-Acetyl-L-Cysteine in Human Oligodendrocyte Progenitor Cells and Restoration of Motor Function in Neonatal Rats with Hypoxic-Ischemic Encephalopathy

(2015) Dongsun Park et al.   Evidence-based Complementary and Alternative Medicine

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Coenzyme Q10 on the Incidence of Atrial Fibrillation in Patients With Heart Failure

(2015) Qingyan Zhao et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

On the antioxidant properties of erythropoietin and its association with the oxidative-nitrosative stress response to hypoxia in humans

(2014) D. M. Bailey et al.   Acta Physiologica

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia

(2013) Daniel Alonso-Alconada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

(2013) Anne CC Lee et al.   PEDIATRIC RESEARCH

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate

(2012) J C Barrera-de León et al.   Journal of Perinatology

Effect of Therapeutic Hypothermia on Oxidative Stress and Outcome in Term Neonates with Perinatal Asphyxia: A Randomized Controlled Trial

(2012) R. Joy et al.   JOURNAL OF TROPICAL PEDIATRICS

The role of oxidative stress in perinatal hypoxic-ischemic brain injury

(2012) Brankica Vasiljevic et al.   Srpski Arhiv za Celokupno Lekarstvo

The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

(2012) Bor-Jen Lee et al.   TheScientificWorldJOURNAL

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

(2011) Marzia Perluigi et al.   ANTIOXIDANTS & REDOX SIGNALING

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Lipid peroxidation and neurodegenerative disease

(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

Is Caffeine a Good Scavenger of Oxygenated Free Radicals?

(2011) Jorge Rafael León-Carmona et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hypoxic preconditioning involves system Xc− regulation in mouse neural stem cells

(2011) Brian Sims et al.   Stem Cell Research

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN

(2008) Catherine E. Hobbs et al.   PEDIATRICS INTERNATIONAL

Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia–ischemia

(2008) Georgios Papazisis et al.   PHARMACOLOGICAL RESEARCH

Dose-Response Relationships between Iron Deficiency with or without Anemia and Infant Social-Emotional Behavior

(2007) Betsy Lozoff et al.   JOURNAL OF PEDIATRICS