The blood–brain barrier in systemic infection and inflammation

Human glycocalyx shedding: Systematic review and critical appraisal

(2021) Robert G. Hahn et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

The S1P2 receptor regulates blood-brain barrier integrity and leukocyte extravasation with implications for neurodegenerative disease

(2021) Ping Xiang et al.   NEUROCHEMISTRY INTERNATIONAL

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer’s disease

(2021) Daniel Asby et al.   BRAIN

Endothelial glycocalyx in traumatic brain injury associated coagulopathy: potential mechanisms and impact

(2021) Zhimin Zou et al.   Journal of Neuroinflammation

Potential effects of antibiotic‐induced gut microbiome alteration on blood–brain barrier permeability compromise in rhesus monkeys

(2020) Qiong Wu et al.   Annals of the New York Academy of Sciences

Emergence and Developmental Roles of the Cerebrospinal Fluid System

(2020) Ryann M. Fame et al.   DEVELOPMENTAL CELL

Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance

(2020) Zachary Papadopoulos et al.   JOURNAL OF IMMUNOLOGY

The endothelial glycocalyx: Structure and function in health and critical illness

(2020) Sarah Gaudette et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

(2020) Philip Kitchen et al.   CELL

The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain

(2020) Xueli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes

(2020) Carolyn A. Thomson et al.   Journal of Neuroinflammation

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

(2020) Tamas Kiss et al.   GeroScience

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

Increase in blood–brain barrier leakage in healthy, older adults

(2020) Inge C. M. Verheggen et al.   GeroScience

Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment

(2020) Lyna Kamintsky et al.   ANNALS OF THE RHEUMATIC DISEASES

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

(2020) Kevin R. Parker et al.   CELL

Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis

(2020) Willian Margotti et al.   EXPERIMENTAL GERONTOLOGY

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

(2020) Nicholas E. Propson et al.   JOURNAL OF CLINICAL INVESTIGATION

Microvascular Injury in the Brains of Patients with Covid-19

(2020) Myoung-Hwa Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological Changes in Microvascular Morphology, Density, Size and Responses Following Comorbid Cerebral Injury

(2019) Zareen Amtul et al.   Frontiers in Aging Neuroscience

Astrocytic endfeet re-cover blood vessels after removal by laser ablation

(2019) Hideaki Kubotera et al.   Scientific Reports

Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation

(2019) Jessica Cait et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbe to Brain Signaling: What Happens in Vagus…

(2019) Christine Fülling et al.   NEURON

Chimeric Antigen Receptor T Cell-Related Neurotoxicity: Mechanisms, Clinical Presentation, and Approach to Treatment

(2019) Jessica Rice et al.   Current Treatment Options in Neurology

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

(2019) Yu Yamazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown

(2019) Marion Griton et al.   BRAIN BEHAVIOR AND IMMUNITY

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

The blood-brain interface: a culture change

(2018) Ian Galea et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of aquaporin-4 in synaptic plasticity, memory and disease

(2018) Jacqueline A. Hubbard et al.   BRAIN RESEARCH BULLETIN

Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide

(2018) Nobuyuki Nosaka et al.   JOURNAL OF MEDICAL VIROLOGY

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

(2018) Lesley Hoyles et al.   Microbiome

Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers

(2018) Cristina Parrado-Fernández et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity

(2018) Michelle A. Erickson et al.   PLoS One

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

(2018) Nikolay Kutuzov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier permeability measured using dynamic contrast‐enhanced magnetic resonance imaging: a validation study

(2018) Aravinthan Varatharaj et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier

(2018) Yoshiaki Ando et al.   Scientific Reports

Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption

(2017) Rajkumar Vutukuri et al.   JOURNAL OF NEUROCHEMISTRY

In vivo Imaging of the Cerebral Endothelial Glycocalyx in Mice

(2017) Jin-Hui Yoon et al.   JOURNAL OF VASCULAR RESEARCH

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

Protocol for intraoperative assessment of the human cerebrovascular glycocalyx

(2017) R H L Haeren et al.   BMJ Open

Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior

(2017) Samantha J. Hindle et al.   Cell Reports

Cerebral Gluconeogenesis and Diseases

(2017) James Yip et al.   Frontiers in Pharmacology

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking

(2016) E. Maggioli et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial Activation and Blood-Brain Barrier Injury as Risk Factors for Delirium in Critically Ill Patients*

(2016) Christopher G. Hughes et al.   CRITICAL CARE MEDICINE

Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

(2016) Ting-Ting Song et al.   Journal of Neuroinflammation

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation

(2016) Hao He et al.   Scientific Reports

Fever and sickness behavior: Friend or foe?

(2015) L.M. Harden et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes

(2015) Abhay P. Sagare et al.   NEUROSCIENCE LETTERS

LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels

(2015) Lan-hui Qin et al.   Oxidative Medicine and Cellular Longevity

Senescence-associated inflammatory responses: aging and cancer perspectives

(2015) Audrey Lasry et al.   TRENDS IN IMMUNOLOGY

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

(2015) Jian Song et al.   Cell Reports

Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin

(2015) M. Rizwan Siddiqui et al.   PLoS One

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

(2014) Miguel Alejandro Lopez-Ramirez et al.   FASEB JOURNAL

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of Prostaglandin E2 Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever

(2014) D. B. Wilhelms et al.   JOURNAL OF NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

(2014) B. P. Daniels et al.   mBio

Effect of acute hyaluronidase treatment of the glycocalyx on tracer-based whole body vascular volume estimates in mice

(2013) Jurgen W. G. E. VanTeeffelen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Increased blood–brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

(2013) Shuko Takeda et al.   NEUROBIOLOGY OF AGING

Nanomechanics of the Endothelial Glycocalyx in Experimental Sepsis

(2013) Anne Wiesinger et al.   PLoS One

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Diffusion Properties of Molecules at the Blood-Brain Interface: Potential Contributions of Astrocyte Endfeet to Diffusion Barrier Functions

(2012) M. Nuriya et al.   CEREBRAL CORTEX

Intravenous immunoglobulins prevent the breakdown of the blood-brain barrier in experimentally induced sepsis

(2012) Figen Esen et al.   CRITICAL CARE MEDICINE

Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice

(2012) William A Banks et al.   Journal of Neuroinflammation

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

(2012) R. Takechi et al.   Neurodegenerative Diseases

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

(2011) Clarissa M. Comim et al.   INTENSIVE CARE MEDICINE

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

(2011) Ádám Dénes et al.   Journal of Neuroinflammation

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide

(2010) Ray Chui et al.   Journal of Neuroinflammation

Modulation of the blood–brain barrier permeability by plasma glycoprotein orosomucoid

(2010) Wei Yuan et al.   MICROVASCULAR RESEARCH

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Expression and regulation of toll-like receptors in cerebral endothelial cells

(2010) Péter Nagyőszi et al.   NEUROCHEMISTRY INTERNATIONAL

Disruption of the blood–brain barrier in collagen-induced arthritic mice

(2010) Tsuyoshi Nishioku et al.   NEUROSCIENCE LETTERS

Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation

(2009) H. Zhou et al.   JOURNAL OF IMMUNOLOGY

Systemic Inflammatory Response Reactivates Immune-Mediated Lesions in Rat Brain

(2009) S. Serres et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Glycan Shedding and Leukocyte-Endothelial Adhesion in Postcapillary Venules by Suppression of Matrixmetalloprotease Activity with Doxycycline

(2009) Aaron W. Mulivor et al.   MICROCIRCULATION

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice

(2008) S. Saadoun et al.   BRAIN

Nitric Oxide Isoenzymes Regulate Lipopolysaccharide-Enhanced Insulin Transport across the Blood-Brain Barrier

(2008) William A. Banks et al.   ENDOCRINOLOGY

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

(2008) D Gosselin et al.   MOLECULAR PSYCHIATRY

Immune-to-brain signalling: The role of cerebral CD163-positive macrophages

(2008) Ian Galea et al.   NEUROSCIENCE LETTERS