ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

Elevated Cell-Free Mitochondrial DNA in Filtered Plasma Is Associated With HIV Infection and Inflammation

(2018) Omair Arshad et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression

(2018) Yuki Kageyama et al.   JOURNAL OF AFFECTIVE DISORDERS

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

(2018) Nadee Nissanka et al.   Nature Communications

Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease Hippocampi

(2018) Ann C. Rice et al.   JOURNAL OF ALZHEIMERS DISEASE

Cell-free mitochondrial DNA in progressive multiple sclerosis

(2018) Hannah Lowes et al.   MITOCHONDRION

Mechanical ventilation and Streptococcus pneumoniae pneumonia alter mitochondrial homeostasis

(2018) Mathieu Blot et al.   Scientific Reports

Clinical implications and pathological associations of circulating mitochondrial DNA

(2017) Zsolt J Balogh   Frontiers in Bioscience-Landmark

Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

(2017) Sanjay R. Mehta et al.   Journal of Neuroinflammation

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Cerebrospinal fluid mitochondrial DNA in the Alzheimer's disease continuum

(2017) Laura Cervera-Carles et al.   NEUROBIOLOGY OF AGING

MicroRNAs: Roles in Regulating Neuroinflammation

(2017) Andrew D. Gaudet et al.   NEUROSCIENTIST

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

(2017) Pinar E. Coskun et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study

(2016) Małgorzata Wnęk et al.   ACTA NEUROPATHOLOGICA

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

Circulating Cell-Free DNA Differentiates Severity of Inflammation

(2016) M. O. Frank   Biological Research for Nursing

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease

(2016) Petar Podlesniy et al.   NEUROBIOLOGY OF DISEASE

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection

(2016) Ling Li et al.   Scientific Reports

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease

(2015) Angela Pyle et al.   ANNALS OF NEUROLOGY

Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response

(2015) Xiawei Wei et al.   CELL RESEARCH

Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway

(2015) A. Carrizzo et al.   CIRCULATION

Brain diseases and tumorigenesis: The good and bad cops of pentraxin3

(2015) Francesco Fornai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

(2015) N. Tsuji et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Role of mitochondria in regulating microRNA activity and its relevance to the central nervous system

(2015) Wang-Xia Wang et al.   Neural Regeneration Research

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses

(2015) Qianni Hu et al.   PLoS One

Significance of Serum mtDNA Concentration in Lung Injury Induced by Hip Fracture

(2015) Li Gan et al.   SHOCK

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis

(2015) Riccardo Ruffoli et al.   Frontiers in Cellular Neuroscience

Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis

(2015) Gianfranco Natale et al.   Frontiers in Cellular Neuroscience

Circulating Mitochondrial DNA Level, a Noninvasive Biomarker for the Early Detection of Gastric Cancer

(2014) J. Fernandes et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Psychological Stress Activates a Dorsomedial Hypothalamus-Medullary Raphe Circuit Driving Brown Adipose Tissue Thermogenesis and Hyperthermia

(2014) Naoya Kataoka et al.   Cell Metabolism

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

The Role of microRNAs in Mitochondria: Small Players Acting Wide

(2014) Filipe Duarte et al.   Genes

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

(2013) Petar Podlesniy et al.   ANNALS OF NEUROLOGY

Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis

(2013) Roopali Gandhi et al.   ANNALS OF NEUROLOGY

Mitochondrial genome changes and neurodegenerative diseases

(2013) Milena Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuron-Specific Mitochondrial DNA Deletion Levels in Sporadic Alzheimer´s Disease

(2013) Anne Gerschütz et al.   Current Alzheimer Research

MitomiRs delineating the intracellular localization of microRNAs at mitochondria

(2013) S. Bandiera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circulating Mitochondrial DNA Is Elevated in Patients with Immediate Primary Graft Dysfunction

(2013) M. Ibrahim et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

(2013) A. Schipler et al.   NUCLEIC ACIDS RESEARCH

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

(2013) Maarten E. Witte et al.   TRENDS IN MOLECULAR MEDICINE

Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms

(2012) X. Xu et al.   BLOOD

MicroRNA regulation of autophagy

(2012) L. B. Frankel et al.   CARCINOGENESIS

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

(2012) Akihiko Nunomura et al.   NEUROTOXICITY RESEARCH

Plasma Bacterial and Mitochondrial DNA Distinguish Bacterial Sepsis from Sterile SIRS and Quantify Inflammatory Tissue Injury in Nonhuman Primates

(2012) Tolga Sursal et al.   SHOCK

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

(2011) D V Krysko et al.   CELL DEATH AND DIFFERENTIATION

Control of mitochondrial activity by miRNAs

(2011) Peifeng Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Increased plasma levels of extracellular mitochondrial DNA during HIV infection: A new role for mitochondrial damage-associated molecular patterns during inflammation

(2011) Andrea Cossarizza et al.   MITOCHONDRION

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Evaluation of mitochondrial respiratory chain in the brain of rats after pneumococcal meningitis

(2010) Tatiana Barichello et al.   BRAIN RESEARCH BULLETIN

Mitochondrial quality control and neurological disease: an emerging connection

(2010) Inês Pimenta de Castro et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD

(2010) Laura Manuelidis   JOURNAL OF NEUROVIROLOGY

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions

(2010) Paula M Keeney et al.   Molecular Neurodegeneration

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain

(2009) Tero Tapiola et al.   ARCHIVES OF NEUROLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

A biomarker and a target for progressive MS

(2009) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Penetrance of LRRK2 mutations in familial Parkinson disease

(2009)   Nature Reviews Neurology

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

(2008) Walter J. Lukiw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE